ENSMUSG00000021662


Mus musculus

Features
Gene ID: ENSMUSG00000021662
  
Biological name :Arhgef28
  
Synonyms : Arhgef28 / Rho guanine nucleotide exchange factor 28
  
Possible biological names infered from orthology : Q8N1W1
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D1
Gene start: 97899469
Gene end: 98206439
  
Corresponding Affymetrix probe sets: 10411395 (MoGene1.0st)   1419457_at (Mouse Genome 430 2.0 Array)   1419458_at (Mouse Genome 430 2.0 Array)   1431161_at (Mouse Genome 430 2.0 Array)   1443982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153000
Ensembl peptide - ENSMUSP00000153423
Ensembl peptide - ENSMUSP00000153114
Ensembl peptide - ENSMUSP00000105053
NCBI entrez gene - 110596     See in Manteia.
MGI - MGI:1346016
RefSeq - XM_017315362
RefSeq - XM_006517518
RefSeq - XM_006517519
RefSeq - XM_006517521
RefSeq - XM_006517522
RefSeq - XM_017315361
RefSeq - NM_012026
RefSeq Peptide - NP_036156
swissprot - A0A286YD71
swissprot - G5E8P2
swissprot - A0A286YCY0
swissprot - A0A286YDI4
Ensembl - ENSMUSG00000021662
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef28ENSDARG00000060415Danio rerio
 si:ch211-272b8.6ENSDARG00000091607Danio rerio
 ARHGEF28ENSGALG00000014923Gallus gallus
 Q8N1W1ENSG00000214944Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Akap13 / E9Q394 / A-kinase anchor protein 13 / Q12802* / A-kinase anchoring protein 13*ENSMUSG0000006640632
Q6P9R4 / Arhgef18 / Rho guanine nucleotide exchange factor 18 / Q6ZSZ5* / AC008878.3* / Rho/Rac guanine nucleotide exchange factor 18*ENSMUSG0000000456823
Q60875 / Arhgef2 / Rho guanine nucleotide exchange factor 2 / Q92974* / Rho/Rac guanine nucleotide exchange factor 2*ENSMUSG0000002805919
Q8R4H2 / Arhgef12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q9NZN5* / Rho guanine nucleotide exchange factor 12*ENSMUSG0000005949514
Arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSMUSG0000004197714
Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*ENSMUSG0000004094010
Q91X46 / Arhgef3 / Rho guanine nucleotide exchange factor 3 / Q9NR81*ENSMUSG000000218956
Net1 / Q9Z206 / neuroepithelial cell transforming gene 1 / Q7Z628* / neuroepithelial cell transforming 1*ENSMUSG000000212156


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

 MP:0011708 decreased fibroblast cell migration "reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Krastm1.1Hbji/Krastm1.1Hbji,Trp53tm5Tyj/Trp53tm5Tyj
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / reaction / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction / complex






 

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