ENSDARG00000060415


Danio rerio

Features
Gene ID: ENSDARG00000060415
  
Biological name :arhgef28
  
Synonyms : arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28
  
Possible biological names infered from orthology : Q8N1W1 / Rho guanine nucleotide exchange factor 28
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 34827614
Gene end: 34964830
  
Corresponding Affymetrix probe sets: Dr.24090.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000116715
Ensembl peptide - ENSDARP00000145121
Ensembl peptide - ENSDARP00000079521
NCBI entrez gene - 559941     See in Manteia.
RefSeq - XM_017356272
RefSeq - XM_021476534
swissprot - F1R083
swissprot - F6P6M2
ZFIN ID - ZDB-GENE-060531-28
Ensembl - ENSDARG00000060415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF28ENSGALG00000014923Gallus gallus
 Q8N1W1ENSG00000214944Homo sapiens
 Arhgef28ENSMUSG00000021662Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKAP13 / si:dkey-187e18.1 / E9Q394* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000007999425
si:dkey-172h23.2 / E9Q394* / AKAP13* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000002386825
arhgef18b / rho/rac guanine nucleotide exchange factor (GEF) 18b / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000004230820
si:ch211-272b8.6 / Q8N1W1* / ARHGEF28* / Rho guanine nucleotide exchange factor 28*ENSDARG0000009160719
arhgef1a / Rho guanine nucleotide exchange factor (GEF) 1a / Q92974* / Q60875* / ARHGEF2* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000004038017
arhgef18a / rho/rac guanine nucleotide exchange factor (GEF) 18a / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000001115716
arhgef2 / rho/rac guanine nucleotide exchange factor (GEF) 2 / Q92974* / Q60875* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000007581916
arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...ENSDARG0000010091312
arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*ENSDARG0000003053212
arhgef1b / Rho guanine nucleotide exchange factor (GEF) 1b / Q61210* / Q92888* / ARHGEF1* / Rho guanine nucleotide exchange factor 1*ENSDARG000000558379
arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSDARG000000524828
si:dkey-91i10.2ENSDARG000000740347
arhgef3l / Rho guanine nucleotide exchange factor (GEF) 3, likeENSDARG000000375545
arhgef3 / Rho guanine nucleotide exchange factor (GEF) 3 / Q91X46* / Q9NR81* / Rho guanine nucleotide exchange factor 3*ENSDARG000000138345
net1 / neuroepithelial cell transforming 1 / Q7Z628* / Q9Z206* / neuroepithelial cell transforming gene 1*ENSDARG000000327655


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR011993  PH-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0060415 muscle tissue morphogenesis IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite disorganized , abnormal
somite sarcomere absent , abnormal
Show

 ZFA:0000610 vertical myoseptum vertical myoseptum morphology , abnormal
vertical myoseptum disorganized , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis decreased length , abnormal
Show

 ZFA:0001462 somite border somite border spatial pattern , abnormal
Show

 ZFA:0009025 myoblast myoblast Golgi apparatus morphology , abnormal
myoblast cell-matrix adhesion arrested , abnormal
myoblast cell-matrix adhesion decreased occurrence , abnormal
Show

 ZFA:0009114 muscle cell muscle cell disorganized , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell spatial pattern , abnormal
slow muscle cell disorganized , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell disorganized , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000042277 efnb3b / ephrin-B3b / EFNB3* / Q15768* / ephrin B3*  / complex / reaction
 ENSDARG00000007723 efnb1 / ephrin-B1 / P52795* / P98172*  / reaction / complex
 ENSDARG00000037373 ephb2a / eph receptor B2a / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / reaction / complex
 ENSDARG00000021539 ephb2b / eph receptor B2b / EPHB2* / P29323* / P54763* / EPH receptor B2* / Ephrin type-B receptor 2 *  / reaction / complex
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction
 ENSDARG00000112993 efnb3a / ephrin-B3a / EFNB3* / Q15768* / O35393* / ephrin B3*  / reaction / complex
 ENSDARG00000074050 efnb2b / ephrin-B2b / EFNB2* / P52800* / P52799* / ephrin B2*  / complex / reaction
 ENSDARG00000020164 efnb2a / O73874 / ephrin-B2a / EFNB2* / P52799* / P52800* / ephrin B2*  / reaction / complex
 ENSDARG00000076757 ephb1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / reaction / complex






 

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