ENSDARG00000011157


Danio rerio

Features
Gene ID: ENSDARG00000011157
  
Biological name :arhgef18a
  
Synonyms : arhgef18a / rho/rac guanine nucleotide exchange factor (GEF) 18a
  
Possible biological names infered from orthology : AC008878.3 / ARHGEF18 / Q6P9R4 / Q6ZSZ5 / Rho guanine nucleotide exchange factor 18 / Rho/Rac guanine nucleotide exchange factor 18
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 37504244
Gene end: 37537904
  
Corresponding Affymetrix probe sets: Dr.9086.1.A1_at (Zebrafish Array)   NM_214818_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000112773
Ensembl peptide - ENSDARP00000121888
Ensembl peptide - ENSDARP00000016874
NCBI entrez gene - 407987     See in Manteia.
RefSeq - XM_005171284
RefSeq - XM_009298637
RefSeq - XM_021479667
RefSeq - NM_214818
RefSeq Peptide - NP_999983
swissprot - F1REH9
swissprot - E9QEI1
swissprot - E9QEP7
ZFIN ID - ZDB-GENE-040516-14
Ensembl - ENSDARG00000011157
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000003572Gallus gallus
 AC008878.3ENSG00000268861Homo sapiens
 Q6ZSZ5ENSG00000104880Homo sapiens
 Q6P9R4ENSMUSG00000004568Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef18b / rho/rac guanine nucleotide exchange factor (GEF) 18b / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG0000004230846
si:dkey-172h23.2 / E9Q394* / AKAP13* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000002386830
arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28 / Q8N1W1* / Rho guanine nucleotide exchange factor 28*ENSDARG0000006041530
AKAP13 / si:dkey-187e18.1 / E9Q394* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000007999429
arhgef1a / Rho guanine nucleotide exchange factor (GEF) 1a / Q92974* / Q60875* / ARHGEF2* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000004038024
arhgef2 / rho/rac guanine nucleotide exchange factor (GEF) 2 / Q92974* / Q60875* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000007581923
si:ch211-272b8.6 / Q8N1W1* / ARHGEF28* / Rho guanine nucleotide exchange factor 28*ENSDARG0000009160723
arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSDARG0000005248214
arhgef1b / Rho guanine nucleotide exchange factor (GEF) 1b / Q61210* / Q92888* / ARHGEF1* / Rho guanine nucleotide exchange factor 1*ENSDARG0000005583714
arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b / Q8R4H2* / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12* / Mus musculus Rho guanine nucleotide exchange fact...ENSDARG0000010091314
arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*ENSDARG0000003053214
arhgef3l / Rho guanine nucleotide exchange factor (GEF) 3, likeENSDARG000000375548
net1 / neuroepithelial cell transforming 1 / Q7Z628* / Q9Z206* / neuroepithelial cell transforming gene 1*ENSDARG000000327658
arhgef3 / Rho guanine nucleotide exchange factor (GEF) 3 / Q91X46* / Q9NR81* / Rho guanine nucleotide exchange factor 3*ENSDARG000000138348
si:dkey-91i10.2ENSDARG000000740347


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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