ENSDARG00000100913


Danio rerio

Features
Gene ID: ENSDARG00000100913
  
Biological name :arhgef12b
  
Synonyms : arhgef12b / Rho guanine nucleotide exchange factor (GEF) 12b
  
Possible biological names infered from orthology : ARHGEF12 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q8R4H2 / Q9NZN5 / Rho guanine nucleotide exchange factor 12
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 58695838
Gene end: 58832332
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000139791
Ensembl peptide - ENSDARP00000141544
NCBI entrez gene - 571031     See in Manteia.
RefSeq - XM_009301885
RefSeq - XM_009301886
RefSeq - XM_009301887
swissprot - A0A0R4IVL9
swissprot - A0A0R4IRY4
ZFIN ID - ZDB-GENE-070705-36
Ensembl - ENSDARG00000100913
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF12ENSGALG00000006663Gallus gallus
 Q9NZN5ENSG00000196914Homo sapiens
 Q8R4H2ENSMUSG00000059495Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef12a / Rho guanine nucleotide exchange factor (GEF) 12a / Q9NZN5* / ARHGEF12* / Rho guanine nucleotide exchange factor 12*ENSDARG0000003053255
arhgef1b / Rho guanine nucleotide exchange factor (GEF) 1b / Q61210* / Q92888* / ARHGEF1* / Rho guanine nucleotide exchange factor 1*ENSDARG0000005583722
arhgef11 / Rho guanine nucleotide exchange factor (GEF) 11 / O15085* / Rho guanine nucleotide exchange factor 11*ENSDARG0000005248216
arhgef28 / Rho guanine nucleotide exchange factor (GEF) 28 / Q8N1W1* / Rho guanine nucleotide exchange factor 28*ENSDARG0000006041515
si:dkey-172h23.2 / E9Q394* / AKAP13* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000002386814
AKAP13 / si:dkey-187e18.1 / E9Q394* / Q12802* / A-kinase anchor protein 13 * / A-kinase anchoring protein 13*ENSDARG0000007999414
arhgef2 / rho/rac guanine nucleotide exchange factor (GEF) 2 / Q92974* / Q60875* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000007581910
arhgef1a / Rho guanine nucleotide exchange factor (GEF) 1a / Q92974* / Q60875* / ARHGEF2* / Rho guanine nucleotide exchange factor 2 * / Rho/Rac guanine nucleotide exchange factor 2*ENSDARG0000004038010
si:dkey-91i10.2ENSDARG000000740349
si:ch211-272b8.6 / Q8N1W1* / ARHGEF28* / Rho guanine nucleotide exchange factor 28*ENSDARG000000916079
arhgef18b / rho/rac guanine nucleotide exchange factor (GEF) 18b / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG000000423089
arhgef18a / rho/rac guanine nucleotide exchange factor (GEF) 18a / Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exc...ENSDARG000000111579
arhgef3l / Rho guanine nucleotide exchange factor (GEF) 3, likeENSDARG000000375546
net1 / neuroepithelial cell transforming 1 / Q7Z628* / Q9Z206* / neuroepithelial cell transforming gene 1*ENSDARG000000327656
arhgef3 / Rho guanine nucleotide exchange factor (GEF) 3 / Q91X46* / Q9NR81* / Rho guanine nucleotide exchange factor 3*ENSDARG000000138346


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015212  Regulator of G protein signalling-like domain
 IPR016137  RGS domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000025826 gna12a / guanine nucleotide binding protein (G protein) alpha 12a / GNA12* / Q03113* / P27600* / G protein subunit alpha 12* / guanine nucleotide binding protein, alpha 12*  / reaction / complex
 ENSDARG00000073765 gna13a / guanine nucleotide binding protein (G protein), alpha 13a / GNA13* / Q14344* / P27601* / G protein subunit alpha 13* / guanine nucleotide binding protein, alpha 13*  / complex / reaction
 ENSDARG00000004218 rnd1b / Rho family GTPase 1b / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / complex / reaction
 ENSDARG00000026294 erbb2 / erb-b2 receptor tyrosine kinase 2 / P04626* / P70424* / Receptor tyrosine-protein kinase erbB-2 *  / reaction / complex
 ENSDARG00000030547 rnd1a / Rho family GTPase 1a / RND1* / Q92730* / Q8BLR7* / Rho family GTPase 1* / Rho-related GTP-binding protein Rho6 *  / complex / reaction
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction
 ENSDARG00000018328 rhocb / Q6DHE8 / ras homolog family member Cb / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *  / reaction
 ENSDARG00000021309 rhoca / ras homolog family member Ca / RHOC* / Q62159* / P08134* / ras homolog family member C* / Rho-related GTP-binding protein RhoC *  / reaction






 

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