ENSGALG00000006663


Gallus gallus

Features
Gene ID: ENSGALG00000006663
  
Biological name :ARHGEF12
  
Synonyms : ARHGEF12 / Rho guanine nucleotide exchange factor 12
  
Possible biological names infered from orthology : Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA. / Q8R4H2 / Q9NZN5
  
Species: Gallus gallus
  
Chr. number: 24
Strand: -1
Band:
Gene start: 3718300
Gene end: 3780408
  
Corresponding Affymetrix probe sets: Gga.16743.2.S1_at (Chicken Array)   GgaAffx.4150.1.S1_at (Chicken Array)   GgaAffx.4150.2.S1_s_at (Chicken Array)   GgaAffx.4150.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000056709
Ensembl peptide - ENSGALP00000010766
NCBI entrez gene - 419752     See in Manteia.
RefSeq - XM_417890
RefSeq - XM_015298183
RefSeq - XM_015298184
swissprot - F1P1Y1
swissprot - A0A1D5PUV1
Ensembl - ENSGALG00000006663
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef12aENSDARG00000030532Danio rerio
 arhgef12bENSDARG00000100913Danio rerio
 Q9NZN5ENSG00000196914Homo sapiens
 Q8R4H2ENSMUSG00000059495Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARHGEF11 / Rho guanine nucleotide exchange factor 11 / O15085* / Rho guanine nucleotide exchange factor (GEF) 11*ENSGALG0000003916330
ARHGEF28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*ENSGALG0000001492315
AKAP13 / A-kinase anchoring protein 13 / E9Q394* / Q12802* / A-kinase anchor protein 13 *ENSGALG0000000684012
Q6P9R4* / Q6ZSZ5* / ARHGEF18* / AC008878.3* / Rho guanine nucleotide exchange factor 18 * / Rho/Rac guanine nucleotide exchange factor 18*ENSGALG0000000357211
NET1 / neuroepithelial cell transforming 1 / Q7Z628* / Q9Z206* / neuroepithelial cell transforming gene 1*ENSGALG000000084377
ARHGEF3 / rho guanine nucleotide exchange factor 3 / Q91X46* / Q9NR81*ENSGALG000000054817
ENSGALG000000264605


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015212  Regulator of G protein signalling-like domain
 IPR016137  RGS domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000036028 GNA13 / G protein subunit alpha 13 / P27601* / Q14344* / guanine nucleotide binding protein, alpha 13*  / reaction / complex
 ENSGALG00000016485 RHOB / ras homolog family member B / P62745* / P62746*  / reaction
 ENSGALG00000001569 RHOC / Q9PSX7 / Rho-related GTP-binding protein RhoC / Q62159* / P08134* / ras homolog family member C*  / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction
 ENSGALG00000010697 SEMA4D / semaphorin-4D precursor / O09126* / Q92854* / semaphorin 4D*  / complex / reaction
 ENSGALG00000006526 PLXNB1 / plexin B1 / O43157* / Q8CJH3*  / complex / reaction






 

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