ENSGALG00000016485


Gallus gallus

Features
Gene ID: ENSGALG00000016485
  
Biological name :RHOB
  
Synonyms : ras homolog family member B / RHOB
  
Possible biological names infered from orthology : P62745 / P62746
  
Species: Gallus gallus
  
Chr. number: 3
Strand: 1
Band:
Gene start: 102140473
Gene end: 102142807
  
Corresponding Affymetrix probe sets: Gga.3852.1.S1_at (Chicken Array)   Gga.3852.1.S2_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000026544
NCBI entrez gene - 395734     See in Manteia.
RefSeq - NM_204909
RefSeq Peptide - NP_990240
swissprot - O93468
Ensembl - ENSGALG00000016485
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RHOBENSG00000143878Homo sapiens
 RhobENSMUSG00000054364Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RHOC / Q9PSX7 / Rho-related GTP-binding protein RhoC / Q62159* / P08134* / ras homolog family member C*ENSGALG0000000156984
RHOA / ras homolog family member A / P61586* / 4930544G11Rik* / RIKEN cDNA 4930544G11 gene*ENSGALG0000000380678
RHOF / ras homolog family member F, filopodia associated / Q8BYP3* / Q9HBH0* / ras homolog family member F (in filopodia)*ENSGALG0000003972448
RND2 / Rho family GTPase 2 / P52198* / Q9QYM5*ENSGALG0000000280445
RND3 / Rho family GTPase 3 / P61587* / P61588* / Rho-related GTP-binding protein RhoE *ENSGALG0000002631345
ENSGALG0000004477444


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0008333 endosome to lysosome transport IEA
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0061154 endothelial tube morphogenesis IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071479 cellular response to ionizing radiation IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032154 cleavage furrow IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Rho GTPase cycle
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases Activate Formins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / complex / reaction
 ENSGALG00000006526 PLXNB1 / plexin B1 / O43157* / Q8CJH3*  / reaction
 ENSGALG00000006663 ARHGEF12 / Rho guanine nucleotide exchange factor 12 / Q8R4H2* / Q9NZN5* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA.*  / reaction
 ENSGALG00000014922 ROCK1 / Rho associated coiled-coil containing protein kinase 1 / P70335* / Q13464* / Rho-associated protein kinase 1 *  / reaction / complex
 ENSGALG00000016451 ROCK2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / complex / reaction
 ENSGALG00000010697 SEMA4D / semaphorin-4D precursor / O09126* / Q92854* / semaphorin 4D*  / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / reaction






 

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