ENSGALG00000010697


Gallus gallus

Features
Gene ID: ENSGALG00000010697
  
Biological name :SEMA4D
  
Synonyms : SEMA4D / semaphorin-4D precursor
  
Possible biological names infered from orthology : O09126 / Q92854 / semaphorin 4D
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 43599371
Gene end: 43624509
  
Corresponding Affymetrix probe sets: Gga.766.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000037144
NCBI entrez gene - 396331     See in Manteia.
RefSeq - XM_015280268
RefSeq - NM_001293102
RefSeq - XM_015280266
RefSeq - XM_015280267
RefSeq - XM_015280258
RefSeq - XM_015280259
RefSeq - XM_015280260
RefSeq - XM_015280261
RefSeq - XM_015280262
RefSeq - XM_015280263
RefSeq - XM_015280264
RefSeq - XM_015280265
RefSeq Peptide - NP_001280031
swissprot - F1NCF9
Ensembl - ENSGALG00000010697
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEMA4DENSDARG00000067801Danio rerio
 Q92854ENSG00000187764Homo sapiens
 O09126ENSMUSG00000021451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ENSGALG0000000305837
SEMA4G / semaphorin 4G / Q9NTN9* / Q9WUH7*ENSGALG0000002695732
SEMA4B / semaphorin 4B / Q62179*ENSGALG0000000829732
SEMA3A / semaphorin-3A / O08665* / Q14563*ENSGALG0000000656029
SEMA3E / semaphorin-3E precursor / P70275* / O15041* / semaphorin 3E* / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E*ENSGALG0000003822527
Q90663 / SEMA3D / Semaphorin-3D / O95025* / Q8BH34*ENSGALG0000000656327
SEMA3C / semaphorin-3C precursor / Q62181* / Q99985* / semaphorin 3C*ENSGALG0000004044425
SEMA3B / semaphorin 3B / Q13214* / sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B*ENSGALG0000001372225
SEMA3G / semaphorin 3G / Q4LFA9* / Q9NS98*ENSGALG0000000447625
SEMA3F / semaphorin-3F precursor / O88632* / Q13275* / semaphorin 3F*ENSGALG0000002962123


Protein motifs (from Interpro)
Interpro ID Name
 IPR001627  Sema domain
 IPR002165  Plexin repeat
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR027231  Semaphorin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007162 negative regulation of cell adhesion IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010693 negative regulation of alkaline phosphatase activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031344 regulation of cell projection organization IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043931 ossification involved in bone maturation IEA
 biological_processGO:0045668 negative regulation of osteoblast differentiation IEA
 biological_processGO:0048672 positive regulation of collateral sprouting IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0050919 negative chemotaxis IBA
 biological_processGO:0070486 leukocyte aggregation IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0030215 semaphorin receptor binding IEA


Pathways (from Reactome)
Pathway description
Sema4D mediated inhibition of cell attachment and migration
Sema4D induced cell migration and growth-cone collapse
Other semaphorin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction / complex
 ENSGALG00000006526 PLXNB1 / plexin B1 / O43157* / Q8CJH3*  / reaction / complex
 ENSGALG00000006663 ARHGEF12 / Rho guanine nucleotide exchange factor 12 / Q8R4H2* / Q9NZN5* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 12 (Arhgef12), transcript variant 2, mRNA.*  / reaction / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000002383 CD72AG / CD72* / P21854* / P21855* / CD72 molecule* / B-cell differentiation antigen CD72 *  / complex / reaction
 ENSGALG00000010697 SEMA4D / semaphorin-4D precursor / O09126* / Q92854* / semaphorin 4D*  / complex
 ENSGALG00000001569 RHOC / Q9PSX7 / Rho-related GTP-binding protein RhoC / Q62159* / P08134* / ras homolog family member C*  / reaction
 ENSGALG00000016485 RHOB / ras homolog family member B / P62745* / P62746*  / reaction
 ENSGALG00000031529 ERBB2 / receptor tyrosine-protein kinase erbB-2 precursor / P04626* / P70424* / erb-b2 receptor tyrosine kinase 2* / Receptor tyrosine-protein kinase erbB-2 *  / complex / reaction






 

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