ENSGALG00000036883


Gallus gallus

Features
Gene ID: ENSGALG00000036883
  
Biological name :MET
  
Synonyms : hepatocyte growth factor receptor precursor / MET
  
Possible biological names infered from orthology : MET proto-oncogene, receptor tyrosine kinase / P08581
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 24918557
Gene end: 25006337
  
Corresponding Affymetrix probe sets: Gga.13923.1.S1_at (Chicken Array)   Gga.669.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054618
NCBI entrez gene - 396134     See in Manteia.
RefSeq - NM_205212
RefSeq - XM_015279209
RefSeq - XM_015279251
RefSeq Peptide - NP_990543
swissprot - F1P040
Ensembl - ENSGALG00000036883
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 metENSDARG00000070903Danio rerio
 METENSG00000105976Homo sapiens
 MetENSMUSG00000009376Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MST1R / macrophage-stimulating protein receptor precursor / Q04912* / Q62190* / macrophage stimulating 1 receptor* / macrophage stimulating 1 receptor (c-met-related tyrosine kinase)*ENSGALG0000000310338
MERTK / tyrosine-protein kinase Mer precursor / Q12866* / Q60805* / Tyrosine-protein kinase Mer * / MER proto-oncogene, tyrosine kinase*ENSGALG0000000825715
TYRO3 / tyrosine-protein kinase receptor TYRO3 precursor / Q06418* / P55144* / TYRO3 protein tyrosine kinase* / TYRO3 protein tyrosine kinase 3*ENSGALG0000000863114
TEK / TEK receptor tyrosine kinase / Q02763* / Q02858*ENSGALG0000000184013
TIE1 / tyrosine kinase with immunoglobulin like and EGF like domains 1 / P35590* / Q06806*ENSGALG0000000995712
RYK / receptor-like tyrosine kinase / Q01887* / Tyrosine-protein kinase RYK *ENSGALG0000000648811


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001627  Sema domain
 IPR002909  IPT domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016201  PSI domain
 IPR016244  Tyrosine-protein kinase, HGF/MSP receptor
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001886 endothelial cell morphogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051497 negative regulation of stress fiber assembly IEA
 biological_processGO:0061436 establishment of skin barrier IEA
 biological_processGO:0070495 negative regulation of thrombin-activated receptor signaling pathway IEA
 biological_processGO:0071526 semaphorin-plexin signaling pathway IEA
 biological_processGO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death IEA
 biological_processGO:1905098 negative regulation of guanyl-nucleotide exchange factor activity IEA
 biological_processGO:2001028 positive regulation of endothelial cell chemotaxis IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Sema4D mediated inhibition of cell attachment and migration
RAF/MAP kinase cascade
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
NTRK2 activates RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001439 RANBP10 / RAN binding protein 10 / Q6VN20*  / complex / reaction
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex / reaction
 ENSGALG00000008010 PTPN1 / tyrosine-protein phosphatase non-receptor type 1 / P18031* / P35821* / protein tyrosine phosphatase, non-receptor type 1*  / reaction
 ENSGALG00000006382 PTPRJ / receptor-type tyrosine-protein phosphatase eta precursor / Q12913* / protein tyrosine phosphatase, receptor type J*  / reaction
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / complex / reaction
 ENSGALG00000008934 PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha / P42336* / P42337* / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform *  / complex / reaction
 ENSGALG00000006390 CRKL / CRK like proto-oncogene, adaptor protein / P46109* / P47941* / Crk-like protein *  / reaction / complex
 ENSGALG00000006526 PLXNB1 / plexin B1 / O43157* / Q8CJH3*  / complex
 ENSGALG00000008016 GRB2 / growth factor receptor-bound protein 2 / P62993* / Q60631*  / reaction / complex
 ENSGALG00000007224 HGS / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / reaction / complex
 ENSGALG00000010543 EPS15 / epidermal growth factor receptor substrate 15 / P42566* / P42567* / epidermal growth factor receptor pathway substrate 15*  / complex / reaction
 ENSGALG00000013867 PTPN2 / protein tyrosine phosphatase, non-receptor type 2 / P17706* / Q06180* / Tyrosine-protein phosphatase non-receptor type 2 *  / reaction
 ENSGALG00000014786 PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1 / P26450* / P27986*  / reaction / complex
 ENSGALG00000033974 HGF / hepatocyte growth factor / P14210* / Q08048* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*  / reaction / complex
 ENSGALG00000007145 ITGB1 / integrin subunit beta 1 / P05556* / P09055* / Integrin beta-1 *  / complex / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / complex / reaction
 ENSGALG00000016420 SH3KBP1 / SH3 domain containing kinase binding protein 1 / Q8R550* / Q96B97*  / complex / reaction
 ENSGALG00000039450 SOS1 / SOS Ras/Rac guanine nucleotide exchange factor 1 / Q07889* / Q62245* / Son of sevenless homolog 1 *  / reaction / complex
 ENSGALG00000009898 GAB1 / GRB2 associated binding protein 1 / Q13480* / Q9QYY0*  / reaction / complex
 ENSGALG00000026944 ARF6 / P26990 / ADP-ribosylation factor 6 / P62330* / P62331*  / complex
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000015096 Q8AXV1 / SH3GL2 / Endophilin-A1 / Q99962* / Q62420* / SH3-domain GRB2-like 2* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction / complex
 ENSGALG00000010697 SEMA4D / semaphorin-4D precursor / O09126* / Q92854* / semaphorin 4D*  / reaction / complex
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000007483 LRIG1 / leucine rich repeats and immunoglobulin like domains 1 / P70193* / Q96JA1* / Leucine-rich repeats and immunoglobulin-like domains protein 1 *  / reaction / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000035287 STAM / signal transducing adaptor molecule / P70297* / Q92783* / signal transducing adaptor molecule (SH3 domain and ITAM motif) 1*  / reaction / complex
 ENSGALG00000039139 TNS3 / tensin 3 / Q5SSZ5* / Q68CZ2*  / reaction / complex
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / complex / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000005894 USP8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / reaction






 

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