ENSGALG00000005894


Gallus gallus

Features
Gene ID: ENSGALG00000005894
  
Biological name :USP8
  
Synonyms : ubiquitin specific peptidase 8 / USP8
  
Possible biological names infered from orthology : P40818 / Q80U87
  
Species: Gallus gallus
  
Chr. number: 10
Strand: -1
Band:
Gene start: 10830063
Gene end: 10845317
  
Corresponding Affymetrix probe sets: Gga.9603.1.S1_s_at (Chicken Array)   Gga.9669.1.S1_at (Chicken Array)   GgaAffx.21107.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000051754
NCBI entrez gene - 415451     See in Manteia.
RefSeq - XM_015292018
RefSeq - XM_015292019
RefSeq - XM_015292020
RefSeq - XM_015292021
RefSeq - XM_015292017
swissprot - A0A1D5PG34
Ensembl - ENSGALG00000005894
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 usp8ENSDARG00000063719Danio rerio
 USP8ENSG00000138592Homo sapiens
 Usp8ENSMUSG00000027363Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
USP33 / ubiquitin specific peptidase 33 / Q8R5K2* / Q8TEY7*ENSGALG0000000897414
USP2 / ubiquitin specific peptidase 2 / O75604* / O88623*ENSGALG0000000675513
USP20 / ubiquitin specific peptidase 20 / Q8C6M1* / Q9Y2K6*ENSGALG0000004110413
USP16 / ubiquitin specific peptidase 16 / Q99LG0* / Q9Y5T5*ENSGALG0000001581312
USP45* / Q70EL2* / Q8K387* / ubiquitin specific petidase 45* / ubiquitin specific peptidase 45*ENSGALG000000318147
USP45 / Q70EL2* / Q8K387* / ubiquitin specific petidase 45* / ubiquitin specific peptidase 45*ENSGALG000000154784


Protein motifs (from Interpro)
Interpro ID Name
 IPR001394  Peptidase C19, ubiquitin carboxyl-terminal hydrolase
 IPR001763  Rhodanese-like domain
 IPR015063  USP8 dimerisation domain
 IPR018200  Ubiquitin specific protease, conserved site
 IPR028889  Ubiquitin specific protease domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0007032 endosome organization IEA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IEA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 cellular_componentGO:0030496 midbody IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Downregulation of ERBB2:ERBB3 signaling
Regulation of FZD by ubiquitination
Ub-specific processing proteases
Negative regulation of MET activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000042657 WNT3A / Q2LMP1 / Protein Wnt-3a / P56704* / P27467* / Wnt family member 3A* / wingless-type MMTV integration site family, member 3A*  / reaction
 ENSGALG00000032819 RNF41 / ring finger protein 41 / Q8BH75* / Q9H4P4* / E3 ubiquitin-protein ligase NRDP1 *  / complex / reaction
 ENSGALG00000041977 RNF148* / Q8TEB7* / Q8WVZ7* / Q9D304* / RNF128* / RNF133* / G3X9R7* / Q14B02* / Q8N7C7* / ring finger protein 148* / ring finger protein 133* / E3 ubiquitin-protein ligase RNF133 * / E3 ubi...  / complex
 ENSGALG00000007483 LRIG1 / leucine rich repeats and immunoglobulin like domains 1 / P70193* / Q96JA1* / Leucine-rich repeats and immunoglobulin-like domains protein 1 *  / reaction
 ENSGALG00000036883 MET / hepatocyte growth factor receptor precursor / P08581* / MET proto-oncogene, receptor tyrosine kinase*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction / complex
 ENSGALG00000031503 LRP6 / LDL receptor related protein 6 / O75581*  / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / complex / reaction
 ENSGALG00000017242 FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*  / reaction
 ENSGALG00000007224 HGS / hepatocyte growth factor-regulated tyrosine kinase substrate / O14964* / hepatocyte growth factor-regulated tyrosine kinase substrate isoform 2 *  / complex






 

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