ENSGALG00000031503


Gallus gallus

Features
Gene ID: ENSGALG00000031503
  
Biological name :LRP6
  
Synonyms : LDL receptor related protein 6 / LRP6
  
Possible biological names infered from orthology : O75581
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 71750243
Gene end: 71874216
  
Corresponding Affymetrix probe sets: GgaAffx.7318.1.S1_at (Chicken Array)   GgaAffx.7321.1.S1_at (Chicken Array)   GgaAffx.7322.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000053042
NCBI entrez gene - 419097     See in Manteia.
RefSeq - XM_015290906
RefSeq - XM_015290915
swissprot - A0A1D5PJP6
Ensembl - ENSGALG00000031503
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrp6ENSDARG00000100143Danio rerio
 LRP6ENSG00000070018Homo sapiens
 Lrp6ENSMUSG00000030201Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRP5 / low-density lipoprotein receptor-related protein 5 precursor / O75197* / Q91VN0* / LDL receptor related protein 5* / Low-density lipoprotein receptor-related protein 5 *ENSGALG0000002953372
LRP4 / LDL receptor related protein 4 / O75096* / Q8VI56* / Low-density lipoprotein receptor-related protein 4 *ENSGALG0000003218137
LRP2 / LDL receptor related protein 2 / A2ARV4* / P98164* / low density lipoprotein receptor-related protein 2*ENSGALG0000001085835
LRP1B / LDL receptor related protein 1B / Q9NZR2*ENSGALG0000001240732
LRP8 / low-density lipoprotein receptor-related protein 8 precursor / Q14114* / Q924X6* / LDL receptor related protein 8* / Low-density lipoprotein receptor-related protein 8 *ENSGALG000000106929
VLDLR / P98165 / Very low-density lipoprotein receptor / P98155* / P98156*ENSGALG000000101669
Gm19410*ENSGALG000000231726


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000742  EGF-like domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR017049  Low density lipoprotein receptor-related protein 5/6
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0014029 neural crest formation IEA
 biological_processGO:0014033 neural crest cell differentiation IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0060070 canonical Wnt signaling pathway IEA
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:0071901 negative regulation of protein serine/threonine kinase activity IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000055 positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:1990851 Wnt-Frizzled-LRP5/6 complex IEA
 cellular_componentGO:1990909 Wnt signalosome IEA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005109 frizzled binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0019210 kinase inhibitor activity IEA
 molecular_functionGO:0019534 toxin transmembrane transporter activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA
 molecular_functionGO:0071936 coreceptor activity involved in Wnt signaling pathway IEA


Pathways (from Reactome)
Pathway description
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Regulation of FZD by ubiquitination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001600 DVL1 / dishevelled segment polarity protein 1 / O14640* / P51141* / Segment polarity DVL-1 *  / complex
 ENSGALG00000008414 DVL3 / dishevelled segment polarity protein 3 / Q61062* / Q92997* / Segment polarity DVL-3 *  / complex
 ENSGALG00000009929 SOST / sclerostin / Q9BQB4*  / complex / reaction
 ENSGALG00000029402 AXIN1 / O15169*  / complex / reaction
 ENSGALG00000001028 RNF43 / ring finger protein 43 / Q5NCP0* / Q68DV7* / E3 ubiquitin-protein ligase RNF43 *  / complex / reaction
 ENSGALG00000042657 WNT3A / Q2LMP1 / Protein Wnt-3a / P56704* / P27467* / Wnt family member 3A* / wingless-type MMTV integration site family, member 3A*  / complex
 ENSGALG00000017242 FZD4 / Q9IA05 / Frizzled-4 / Q61088* / Q9ULV1* / frizzled class receptor 4*  / complex
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction
 ENSGALG00000005894 USP8 / ubiquitin specific peptidase 8 / P40818* / Q80U87*  / reaction






 

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