ENSGALG00000010166


Gallus gallus

Features
Gene ID: ENSGALG00000010166
  
Biological name :VLDLR
  
Synonyms : P98165 / Very low-density lipoprotein receptor / VLDLR
  
Possible biological names infered from orthology : P98155 / P98156
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 26557585
Gene end: 26572292
  
Corresponding Affymetrix probe sets: Gga.679.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000016512
NCBI entrez gene - 396154     See in Manteia.
RefSeq - NM_205229
RefSeq - XM_015280076
RefSeq Peptide - NP_990560
swissprot - P98165
swissprot - F1NC45
Ensembl - ENSGALG00000010166
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vldlrENSDARG00000006257Danio rerio
 VLDLRENSG00000147852Homo sapiens
 VldlrENSMUSG00000024924Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRP8 / low-density lipoprotein receptor-related protein 8 precursor / Q14114* / Q924X6* / LDL receptor related protein 8* / Low-density lipoprotein receptor-related protein 8 *ENSGALG0000001069253
LRP4 / LDL receptor related protein 4 / O75096* / Q8VI56* / Low-density lipoprotein receptor-related protein 4 *ENSGALG0000003218136
LRP2 / LDL receptor related protein 2 / A2ARV4* / P98164* / low density lipoprotein receptor-related protein 2*ENSGALG0000001085835
LRP1B / LDL receptor related protein 1B / Q9NZR2*ENSGALG0000001240735
Gm19410*ENSGALG0000002317225
LRP5 / low-density lipoprotein receptor-related protein 5 precursor / O75197* / Q91VN0* / LDL receptor related protein 5* / Low-density lipoprotein receptor-related protein 5 *ENSGALG0000002953317
LRP6 / LDL receptor related protein 6 / O75581*ENSGALG0000003150317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR032931  Very low-density lipoprotein receptor


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0021517 ventral spinal cord development IEP
 biological_processGO:0034436 glycoprotein transport IEA
 biological_processGO:0034447 very-low-density lipoprotein particle clearance IEA
 biological_processGO:0038026 reelin-mediated signaling pathway IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:1900006 positive regulation of dendrite development IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0030228 lipoprotein particle receptor activity IC
 molecular_functionGO:0030229 very-low-density lipoprotein particle receptor activity IEA
 molecular_functionGO:0034185 apolipoprotein binding IPI
 molecular_functionGO:0034189 very-low-density lipoprotein particle binding IEA
 molecular_functionGO:0034437 glycoprotein transporter activity IEA
 molecular_functionGO:0038025 reelin receptor activity IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Reelin signalling pathway
VLDLR internalisation and degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005139 CLTC / clathrin heavy chain / Q00610*  / complex
 ENSGALG00000008432 AP2M1 / Q5ZMP6 / AP-2 complex subunit mu / P84091* / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex
 ENSGALG00000015326 CLTA / clathrin light chain A / P09496*  / complex
 ENSGALG00000016420 SH3KBP1 / SH3 domain containing kinase binding protein 1 / Q8R550* / Q96B97*  / complex / reaction
 ENSGALG00000012704 MYLIP / myosin regulatory light chain interacting protein / Q8BM54* / Q8WY64* / E3 ubiquitin-protein ligase MYLIP *  / reaction
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction
 ENSGALG00000010857 DAB1 / disabled homolog 1 / O75553* / P97318* / DAB1, reelin adaptor protein*  / complex / reaction
 ENSGALG00000042125 AP2B1 / adaptor related protein complex 2 beta 1 subunit / P63010* / Q9DBG3* / AP-2 complex subunit beta *  / complex






 

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