ENSMUSG00000024924


Mus musculus

Features
Gene ID: ENSMUSG00000024924
  
Biological name :Vldlr
  
Synonyms : P98156 / very low density lipoprotein receptor / Vldlr
  
Possible biological names infered from orthology : P98155
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 27216484
Gene end: 27254231
  
Corresponding Affymetrix probe sets: 10462281 (MoGene1.0st)   1417900_a_at (Mouse Genome 430 2.0 Array)   1434465_x_at (Mouse Genome 430 2.0 Array)   1435893_at (Mouse Genome 430 2.0 Array)   1438258_at (Mouse Genome 430 2.0 Array)   1442169_at (Mouse Genome 430 2.0 Array)   1451156_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130382
Ensembl peptide - ENSMUSP00000127329
Ensembl peptide - ENSMUSP00000128193
Ensembl peptide - ENSMUSP00000025866
Ensembl peptide - ENSMUSP00000049145
Ensembl peptide - ENSMUSP00000126730
NCBI entrez gene - 22359     See in Manteia.
MGI - MGI:98935
RefSeq - XM_017318138
RefSeq - NM_001161420
RefSeq - NM_013703
RefSeq - XM_006526917
RefSeq - XM_006526918
RefSeq - XM_006526919
RefSeq - XM_006526920
RefSeq Peptide - NP_001334370
RefSeq Peptide - NP_038731
RefSeq Peptide - NP_001154892
swissprot - F8WGI9
swissprot - F8WIN7
swissprot - F6RKS4
swissprot - Q91YY0
swissprot - E9Q643
swissprot - P98156
Ensembl - ENSMUSG00000024924
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vldlrENSDARG00000006257Danio rerio
 VLDLRENSGALG00000010166Gallus gallus
 VLDLRENSG00000147852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ldlr / P35951 / Low-density lipoprotein receptor / P01130*ENSMUSG0000003219348
Lrp8 / Q924X6 / Low-density lipoprotein receptor-related protein 8 / Q14114* / LDL receptor related protein 8*ENSMUSG0000002861345
Lrp1 / LDL receptor related protein 1 / Q07954*ENSMUSG0000004024936
Lrp4 / Q8VI56 / Low-density lipoprotein receptor-related protein 4 / O75096* / LDL receptor related protein 4*ENSMUSG0000002725336
Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*ENSMUSG0000002707036
Lrp1b / LDL receptor related protein 1B / Q9NZR2*ENSMUSG0000004925234
Gm19410ENSMUSG0000010937229
Lrp5 / Q91VN0 / Low-density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*ENSMUSG0000002491317
Lrp6 / LDL receptor related protein 6 / O75581*ENSMUSG0000003020116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR032931  Very low-density lipoprotein receptor
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0021517 ventral spinal cord development IEP
 biological_processGO:0034436 glycoprotein transport IEA
 biological_processGO:0034447 very-low-density lipoprotein particle clearance IEA
 biological_processGO:0038026 reelin-mediated signaling pathway IGI
 biological_processGO:0045860 positive regulation of protein kinase activity IGI
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:1900006 positive regulation of dendrite development IGI
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030229 very-low-density lipoprotein particle receptor activity ISS
 molecular_functionGO:0034185 apolipoprotein binding IEA
 molecular_functionGO:0034189 very-low-density lipoprotein particle binding IEA
 molecular_functionGO:0034437 glycoprotein transporter activity IEA
 molecular_functionGO:0038025 reelin receptor activity IGI
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Reelin signalling pathway
VLDLR internalisation and degradation
VLDL clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000791 delaminated cerebral cortex "splitting of the layers of the gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:38857]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlr+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vldlrm1Btlr/Vldlrm1Btlr
Genetic Background: C57BL/6J-Vldlrm1Btlr

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S100gtm1Ebje/S100gtm1Ebje
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vldlrm1Btlr/Vldlrm1Btlr
Genetic Background: C57BL/6J-Vldlrm1Btlr

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S100gtm1Ebje/S100gtm1Ebje
Genetic Background: involves: 129P2/OlaHsd

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: S100gtm1Ebje/S100gtm1Ebje
Genetic Background: involves: 129P2/OlaHsd

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atoh7tm1Gan/Atoh7tm1Gan
Genetic Background: Not Specified

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Vldlrm1Btlr/Vldlrm1Btlr
Genetic Background: C57BL/6J-Vldlrm1Btlr

Allelic Composition: Vldlrm1Btlr/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: S100gtm1Ebje/S100gtm1Ebje
Genetic Background: involves: 129P2/OlaHsd

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0003711 abnormal pathological neovascularization "the proliferation of blood vessels in abnormal tissues or in abnormal positions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: S100gtm1Ebje/S100gtm1Ebje
Genetic Background: involves: 129P2/OlaHsd

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Vldlrm1Btlr/Vldlrm1Btlr
Genetic Background: C57BL/6J-Vldlrm1Btlr

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlr+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Vldlrm1Btlr/Vldlrm1Btlr
Genetic Background: C57BL/6J-Vldlrm1Btlr

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: S100gtm1Ebje/S100gtm1Ebje
Genetic Background: involves: 129P2/OlaHsd

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: S100gtm1Ebje/S100gtm1Ebje
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vldlrm1Btlr/Vldlrm1Btlr
Genetic Background: C57BL/6J-Vldlrm1Btlr

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lrp1tm2Her/Lrp1tm2Her,Vldlrtm1Her/Vldlrtm1Her,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005546 choroidal neovascularization "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: S100gtm1Ebje/S100gtm1Ebje
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: B6;129S7-Vldlrtm1Her/J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: B6;129S7-Vldlrtm1Her/J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: B6;129S7-Vldlrtm1Her/J

Allelic Composition: Vldlrm1Btlr/Vldlrm1Btlr
Genetic Background: C57BL/6J-Vldlrm1Btlr

 MP:0008512 disorganized retinal inner nuclear layer "derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: B6;129S7-Vldlrtm1Her/J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: B6;129S7-Vldlrtm1Her/J

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: B6;129S7-Vldlrtm1Her/J

 MP:0008852 retinal neovascularization "formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina" [MESH:C11.768.725]
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Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: B6;129S7-Vldlrtm1Her/J

Allelic Composition: Vldlrtm1Lex/Vldlrtm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040564 Apoc1 / P34928 / Apolipoprotein C-I Truncated apolipoprotein C-I / P02654* / apolipoprotein C1*  / complex / reaction
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / reaction / complex
 ENSMUSG00000044254 Pcsk9 / Q80W65 / Proprotein convertase subtilisin/kexin type 9 / Q8NBP7*  / reaction / complex
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / reaction / complex
 ENSMUSG00000074336 Apoc4 / Q61268 / Apolipoprotein C-IV / P55056* / APOC4-APOC2* / apolipoprotein C4* / APOC4-APOC2 readthrough (NMD candidate)*  / reaction / complex
 ENSMUSG00000040990 Q8R550 / Sh3kbp1 / SH3 domain-containing kinase-binding protein 1 / Q96B97*  / complex / reaction
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / complex / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / complex / reaction
 ENSMUSG00000028519 Dab1 / P97318 / Disabled homolog 1 / O75553* / DAB1, reelin adaptor protein*  / complex / reaction
 ENSMUSG00000042453 Reln / Q60841 / Reelin / P78509*  / reaction / complex
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / reaction / complex
 ENSMUSG00000038175 Mylip / Q8BM54 / E3 ubiquitin-protein ligase MYLIP / Q8WY64* / myosin regulatory light chain interacting protein*  / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction






 

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