Manteia

ID	Phenotype	Definition	Genetic BG
MP:0000136	abnormal microglial cell morphology	"anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0000180	abnormal circulating cholesterol level	"anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scn5a^tm1Pec/Scn5a⁺ Genetic Background: involves: Swiss Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(H2-K-AKR1B1)1Tj/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 Allelic Composition: Apobec1^tm1Chan/Apobec1^tm1Chan,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000181	abnormal circulating LDL cholesterol level	"anomalous concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd
MP:0000182	increased circulating LDL cholesterol level	"greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlrap1^{Gt(OST149604)Lex}/Ldlrap1^{Gt(OST149604)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Olr1^tm1Meht/Olr1^tm1Meht Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC3)3707Bres/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Apobec1^tm1Ddsn Ldlr^tm1Her Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Fgg^tm1Fjc/Fgg^tm1Fjc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Fgg^tm1Fjc Apobec1^tm1Ddsn Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APPSWE)2576Kha/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lipc^tm1Unc/Lipc^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC3)3707Bres/?,Tg(Mt1-CETP)#Tall/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Pcsk9^tm1.2Prat/Pcsk9^tm1.2Prat Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs Genetic Background: B6.129-Apoe^tm1Unc Cx3cl1^tm1Sgs Allelic Composition: Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs,Ldlr^tm1Her/Ldlr⁺ Genetic Background: involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq5^CAST/EiJ/Mobq5^CAST/EiJ Genetic Background: B6.CAST-Mobq5^CAST/EiJ Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq6^CAST/EiJ/Mobq6^CAST/EiJ Genetic Background: B6.CAST-Mobq6^CAST/EiJ Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr0b2^tm1.1Mjev/Nr0b2^tm1.1Mjev Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Crp^tm1Hjf/Crp^tm1Hjf,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Crp^tm1Hjf Ldlr^tm1Her Allelic Composition: Ctss^tm1Hap/Ctss^tm1Hap,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Ctss^tm1Hap Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm3.1Sjns/Nr5a2^tm3.1Sjns Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N
MP:0000186	decreased circulating HDL cholesterol level	"lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^{tm1(APOE2)Mae}/Apoe^{tm1(APOE2)Mae} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq5^CAST/EiJ/Mobq5^CAST/EiJ Genetic Background: B6.CAST-Mobq5^CAST/EiJ Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq6^CAST/EiJ/Mobq6^CAST/EiJ Genetic Background: B6.CAST-Mobq6^CAST/EiJ Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Olr1^tm1Meht/Olr1^tm1Meht Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC3)3707Bres/?,Tg(Mt1-CETP)#Tall/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000187	abnormal triglyceride level	"anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr,Ldlr^tm1Her/Ldlr^tm1Her,Vcam1^tm1Dmil/Vcam1^tm1Dmil Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr,Ldlr^tm1Her/Ldlr^tm1Her,Vcam1^tm1Dmil/Vcam1^tm1Dmil Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr,Ldlr^tm1Her/Ldlr^tm1Her,Vcam1^tm1Dmil/Vcam1^tm1Dmil Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
MP:0000231	hypertension	"sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000343	altered response to myocardial infarction	"change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
MP:0000414	alopecia	"absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]	Show Allelic Composition: Rag1^tm1Bal/Rag1^tm1Bal,Tg(TcraTcrb)1100Mjb/? Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0000604	amyloidosis	"an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rag1^tm1Bal/Rag1^tm1Bal,Tg(TcraTcrb)1100Mjb/? Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0000639	abnormal adrenal gland morphology	"malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]	Show Allelic Composition: Rag1^tm1Bal/Rag1^tm1Bal,Tg(TcraTcrb)1100Mjb/? Genetic Background: involves: 129S4/SvJae * C57BL/6 Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0000781	reduced size of corpus callosum	"smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0000849	abnormal cerebellum morphology	"any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
MP:0000877	abnormal Purkinje cell	"any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0000880	decreased Purkinje cell number	"fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0000952	abnormal CNS glia	"anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0001192	scaly skin	"skin covered with shedding scales or flakes" [J:65146]	Show Allelic Composition: Rag1^tm1Bal/Rag1^tm1Bal,Tg(TcraTcrb)1100Mjb/? Genetic Background: involves: 129S4/SvJae * C57BL/6
MP:0001200	thick skin	"greater depth of skin " [J:47225]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J
MP:0001209	spontaneous skin ulceration	"unpredictable appearance of skin lesions, usually with inflammation" [J:65302]	Show Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0001212	skin lesions	"focal patches of inflammation on the skin" [J:30162]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0001243	abnormal dermal layer morphology	"malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
MP:0001245	thick dermal layer	"increased depth of the dermis" [J:65033]	Show Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0001260	increased body weight	"greater than normal average weight " [J:33400]	Show Allelic Composition: Eln^tm1Dyl/Eln⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001261	obese	"excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlrap1^{Gt(OST149604)Lex}/Ldlrap1^{Gt(OST149604)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her
MP:0001337	dry eyes	"absence of natural or normal moisture in the eye" [J:53284]	Show Allelic Composition: Soat1^tm1Ishi/Soat1^tm1Ishi,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001345	meibomian gland atrophy	"wasting of the sebaceous glands embedded in the tarsal plate of each eyelid resulting in reduced size" [J:65146]	Show Allelic Composition: Soat1^tm1Ishi/Soat1^tm1Ishi,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001364	decreased anxiety-related response	"when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APPSWE)2576Kha/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0001413	abnormal response to new environment	"altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APPSWE)2576Kha/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Ldlrap1^{Gt(OST149604)Lex}/Ldlrap1^{Gt(OST149604)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APPSWE)2576Kha/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc1a2^tm1.1Pros/Slc1a2^tm1.1Pros,Tg(GFAP-cre/ERT2)13Kdmc/0 Genetic Background: involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Chrm2^tm1Minm/Chrm2^tm1Minm,Chrm3^tm1Mmt/Chrm3^tm1Mmt Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lipc^tm1Unc/Lipc^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0001548	hyperlipidemia	"abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Scn5a^tm1Pec/Scn5a⁺ Genetic Background: involves: Swiss
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Lbx1^tm1Cbm/Lbx1^tm1Cbm,Olig3^tm1Tre/Olig3^tm1Tre Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrpap1^tm1Her/Lrpap1^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC1)1Lmh/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apobec1^tm1Chan/Apobec1^tm1Chan,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd Allelic Composition: Apoe^{tm3(APOE4)Mae}/Apoe^{tm3(APOE4)Mae},Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ccl2^tm1Rol/Ccl2^tm1Rol,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr⁺ Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC3)3707Bres/?,Tg(Mt1-CETP)#Tall/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Crp^tm1Hjf/Crp^tm1Hjf,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Crp^tm1Hjf Ldlr^tm1Her Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001554	increased circulating free fatty acid level	"higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Ldlrap1^{Gt(OST149604)Lex}/Ldlrap1^{Gt(OST149604)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001556	increased circulating HDL cholesterol level	"higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]	Show Allelic Composition: Spag16^tm2Jfs/Spag16^tm2Jfs Genetic Background: involves: 129S6/SvEvTac Allelic Composition: Ldlr^Hlb301/Ldlr⁺ Genetic Background: C57BL/6J-Ldlr^Hlb301/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr⁺,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr0b2^tm1.1Mjev/Nr0b2^tm1.1Mjev Genetic Background: involves: 129S/SvEvBrd * 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lipc^tm1Unc/Lipc^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(H2-K-AKR1B1)1Tj/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 Allelic Composition: Ldlr^tm1Her/Ldlr⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 Allelic Composition: Ldlr^tm1Her/Ldlr⁺,Tg(H2-K-AKR1B1)1Tj/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her
MP:0001570	abnormal circulating enzyme level	"aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0001625	cardiac hypertrophy	"an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0001786	skin edema	"accumulation of an excessive amount of fluid in the skin" [J:65039]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
MP:0001798	impaired macrophage phagocytosis	"reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0001805	decreased IgG	"less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ldlrap1^{Gt(OST149604)Lex}/Ldlrap1^{Gt(OST149604)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlrap1^{Gt(OST149604)Lex}/Ldlrap1^{Gt(OST149604)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
MP:0002079	increased circulating insulin level	"greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlrap1^{Gt(OST149604)Lex}/Ldlrap1^{Gt(OST149604)Lex} Genetic Background: involves: 129S5/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6 Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Asgr2^tm1Her/Asgr2⁺ Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Soat1^tm1Ishi/Soat1^tm1Ishi,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apoe^{tm1(APOE2)Mae}/Apoe^{tm1(APOE2)Mae},Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Serpine1^tm1Mlg/Serpine1^tm1Mlg Genetic Background: B6.129S-Serpine1^tm1Mlg Ldlr^tm1Her
MP:0002182	abnormal astrocyte morphology	"anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0002323	resistance to hyperlipidemia	"less likely than the norm to develop abnormally high levels of circulating lipids" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^{tm1(APOE2)Mae}/Apoe^{tm1(APOE2)Mae},Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(H2-K-AKR1B1)1Tj/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0002551	abnormal blood coagulation	"altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Fgg^tm1Fjc/Fgg^tm1Fjc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Fgg^tm1Fjc Apobec1^tm1Ddsn Ldlr^tm1Her
MP:0002625	left ventricle hypertrophy	"increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Emx1^tm1(cre)Yql/Emx1⁺,Tor1a^tm2Yql/Tor1a^tm2Yql Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Angptl3^tm1Lex/Angptl3^tm1Lex,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apobec1^tm1Chan/Apobec1^tm1Chan,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm3.1Sjns/Nr5a2^tm3.1Sjns Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N
MP:0002665	decreased circulating corticosterone level	"less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lipc^tm1Unc/Lipc^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her
MP:0002747	abnormal aortic valve morphology	"malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0002830	gallstones	"caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^Hlb301/Ldlr^Hlb301 Genetic Background: C57BL/6J-Ldlr^Hlb301/J
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002981	increased liver weight	"a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL/6
MP:0003038	decreased infarction size	"decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
MP:0003075	response to CNS ischemic injury		Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003099	retinal detachment	"detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]	Show Allelic Composition: Ldlr^Hlb301/Ldlr^Hlb301 Genetic Background: C57BL/6J-Ldlr^Hlb301/J
MP:0003137	abnormal impulse conducting system conduction	"anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0003156	abnormal lymphocyte migration/homing	"altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]	Show Allelic Composition: Ctss^tm1Hap/Ctss^tm1Hap,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Ctss^tm1Hap Ldlr^tm1Her
MP:0003211	abnormal aorta elastic fiber morphology	"malformation of a slender connective tissue fiber in aortic tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Myh10^tm7Rsad/Myh10^tm7Rsad,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
MP:0003329	amyloid beta deposits		Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Apoe^{tm2(APOE3)Mae}/Apoe^{tm2(APOE3)Mae},Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apoe^{tm3(APOE4)Mae}/Apoe^{tm3(APOE4)Mae},Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APPSWE)2576Kha/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0003333	liver fibrosis	"invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003394	increased cardiac output	"greater than normal blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Esr1^tm1.1Mma/Esr1^tm1.1Mma,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd Allelic Composition: Esr1^tm1Arnal/Esr1^tm1Arnal,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd
MP:0003674	oxidative stress	"condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003691	abnormal microglial cell function	"anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003692	xanthoma	"a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Soat1^tm1Ishi/Soat1^tm1Ishi,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0003718	maternal effect	"expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003799	impaired macrophage migration	"defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Pfn1^tm1Wit/Pfn1⁺ Genetic Background: B6.129S-Ldlr^tm1Her Pfn1^tm1Wit
MP:0003814	vascular smooth muscle cell hypoplasia	"decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ctss^tm1Hap/Ctss^tm1Hap,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Ctss^tm1Hap Ldlr^tm1Her
MP:0003868	abnormal feces composition	"increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA
MP:0003884	decreased macrophage count	"fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ddr1^tm1Wfv/Ddr1^tm1Wfv,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
MP:0003887	increased hepatocyte apoptosis	"increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003897	abnormal ST interval	"anomaly in the time between the end of S-wave and the beginning of T-wave" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0003947	abnormal cholesterol level	"anomaly in the concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0003949	abnormal circulating lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Apoe^{tm2(APOE3)Mae}/Apoe^{tm2(APOE3)Mae},Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apoe^{tm3(APOE4)Mae}/Apoe^{tm3(APOE4)Mae},Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0003961	decreased lean body mass	"less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Ppara^tm1Gonz/Ppara^tm1Gonz Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
MP:0003975	increased circulating VLDL triglyceride level	"higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC1)1Lmh/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0003976	decreased circulating VLDL triglyceride level	"lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0003982	increased cholesterol level	"greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0003983	decreased cholesterol level	"less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm3.1Sjns/Nr5a2^tm3.1Sjns Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N
MP:0003991	arteriosclerosis	"thickening, hardening and/or loss of elasticity of the walls of arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0004112	abnormal arteriole morphology	"structural anomaly in the small diameter vessels that branch from the arteries and lead to the capillaries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004772	abnormal bile secretion	"any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm3.1Sjns/Nr5a2^tm3.1Sjns Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N
MP:0004778	increased foam cell number	"greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]	Show Allelic Composition: Ldlr^Hlb301/Ldlr^Hlb301 Genetic Background: C57BL/6J-Ldlr^Hlb301/J Allelic Composition: Ldlr^Hlb301/Ldlr⁺ Genetic Background: C57BL/6J-Ldlr^Hlb301/J
MP:0004947	skin inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
MP:0005013	increased lymphocyte number	"greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr,Ldlr^tm1Her/Ldlr^tm1Her,Vcam1^tm1Dmil/Vcam1^tm1Dmil Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Jag1^tm2Grid/Jag1^tm2Grid,Tg(Tek-cre)12Flv/0 Genetic Background: involves: C3H * C57BL/6
MP:0005048	thrombosis	"formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lama2^tm1Eeng/Lama2^tm1Eeng,Tg(Myod1-BCL2)1Jbm/? Genetic Background: B6.Cg-Lama2^tm1Eeng Tg(Myod1-BCL2)1Jbm
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005144	abnormal circulating VLDL cholesterol level	"anomalous concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq5^CAST/EiJ/Mobq5^CAST/EiJ Genetic Background: B6.CAST-Mobq5^CAST/EiJ
MP:0005145	increased circulating VLDL cholesterol level	"greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC1)1Lmh/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Olr1^tm1Meht/Olr1^tm1Meht Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC3)3707Bres/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J Allelic Composition: Ccl2^tm1Rol/Ccl2^tm1Rol,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC3)3707Bres/?,Tg(Mt1-CETP)#Tall/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her
MP:0005146	decreased circulating VLDL cholesterol level	"less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq6^CAST/EiJ/Mobq6^CAST/EiJ Genetic Background: B6.CAST-Mobq6^CAST/EiJ Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Cd1d1^tm1Luc/Cd1d1^tm1Luc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Cd1d1^tm1Luc Ldlr^tm1Her Allelic Composition: Crp^tm1Hjf/Crp^tm1Hjf,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Crp^tm1Hjf Ldlr^tm1Her
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lbx1^tm1Cbm/Lbx1^tm1Cbm,Olig3^tm1Tre/Olig3^tm1Tre Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrpap1^tm1Her/Lrpap1^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Soat1^tm1Ishi/Soat1^tm1Ishi,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^Hlb301/Ldlr^Hlb301 Genetic Background: C57BL/6J-Ldlr^Hlb301/J Allelic Composition: Ldlr^Hlb301/Ldlr⁺ Genetic Background: C57BL/6J-Ldlr^Hlb301/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr⁺,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC1)1Lmh/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(CMV-Serpine1)1Dgi/0 Genetic Background: B6.Cg-Ldlr^tm1Her Tg(CMV-Serpine1)1Dgi Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Serpine1^tm1Mlg/Serpine1^tm1Mlg Genetic Background: B6.129S-Serpine1^tm1Mlg Ldlr^tm1Her Allelic Composition: Ldlr^Rgsc366/Ldlr⁺ Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl Allelic Composition: Apobec1^tm1Chan/Apobec1^tm1Chan,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd Allelic Composition: Apoe^{tm3(APOE4)Mae}/Apoe^{tm3(APOE4)Mae},Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APPSWE)2576Kha/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lipc^tm1Unc/Lipc^tm1Unc Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr⁺ Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Crp^tm1Hjf/Crp^tm1Hjf,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Crp^tm1Hjf Ldlr^tm1Her Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs Genetic Background: B6.129-Apoe^tm1Unc Cx3cl1^tm1Sgs Allelic Composition: Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs,Ldlr^tm1Her/Ldlr⁺ Genetic Background: involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr,Ldlr^tm1Her/Ldlr^tm1Her,Vcam1^tm1Dmil/Vcam1^tm1Dmil Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1(LDLR)Mae/Ldlr⁺ Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq5^CAST/EiJ/Mobq5^CAST/EiJ Genetic Background: B6.CAST-Mobq5^CAST/EiJ Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq6^CAST/EiJ/Mobq6^CAST/EiJ Genetic Background: B6.CAST-Mobq6^CAST/EiJ Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Angptl3^tm1Lex/Angptl3^tm1Lex,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Itgb3^tm1Hyn/Itgb3^tm1Hyn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ctss^tm1Hap/Ctss^tm1Hap,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Ctss^tm1Hap Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tlr2^tm1Kir/Tlr2^tm1Kir Genetic Background: B6.129-Tlr2^tm1Kir Ldlr^tm1Her
MP:0005201	abnormal retinal pigment epithelium morphology	"anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005239	abnormal Bruch membrane morphology	"anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005278	abnormal cholesterol homeostasis	"anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]	Show Allelic Composition: Emx1^tm1(cre)Yql/Emx1⁺,Tor1a^tm2Yql/Tor1a^tm2Yql Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm3.1Sjns/Nr5a2^tm3.1Sjns Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq6^CAST/EiJ/Mobq6^CAST/EiJ Genetic Background: B6.CAST-Mobq6^CAST/EiJ
MP:0005293	impaired glucose tolerance	"less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her
MP:0005311	abnormal circulating amino acid level	"aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005318	decreased triglyceride level	"lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005334	abnormal fat pad	"malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0005338	atherosclerotic lesions	"thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scarb1^tm1Dhu/Scarb1^tm1Dhu Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J Allelic Composition: Cxcl1^tm1Wabo/Cxcl1^tm1Wabo,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Gpr132^tm1Witt/Gpr132^tm1Witt,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Gpr132^tm1Witt Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Ldlr^tm1Her Del(11Cxcl16-Zmynd15)1Ifc Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Soat1^tm1Far/Soat1^tm1Far Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(CMV-Serpine1)1Dgi/0 Genetic Background: B6.Cg-Ldlr^tm1Her Tg(CMV-Serpine1)1Dgi Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Serpine1^tm1Mlg/Serpine1^tm1Mlg Genetic Background: B6.129S-Serpine1^tm1Mlg Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOC3)3707Bres/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CBA/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Pfn1^tm1Wit/Pfn1⁺ Genetic Background: B6.129S-Ldlr^tm1Her Pfn1^tm1Wit Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Apobec1^tm1Ddsn Ldlr^tm1Her Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Fgg^tm1Fjc/Fgg^tm1Fjc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Fgg^tm1Fjc Apobec1^tm1Ddsn Ldlr^tm1Her Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Ddr1^tm1Wfv/Ddr1^tm1Wfv,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ Allelic Composition: Itgb3^tm1Hyn/Itgb3^tm1Hyn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cd1d1^tm1Luc/Cd1d1^tm1Luc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Cd1d1^tm1Luc Ldlr^tm1Her Allelic Composition: Ifng^tm1Ts/Ifng^tm1Ts,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Ifng^tm1Ts Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Crp^tm1Hjf/Crp^tm1Hjf,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Crp^tm1Hjf Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tlr2^tm1Kir/Tlr2^tm1Kir Genetic Background: B6.129-Tlr2^tm1Kir Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005339	increased susceptibility to atherosclerosis	"more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^Hlb301/Ldlr^Hlb301 Genetic Background: C57BL/6J-Ldlr^Hlb301/J Allelic Composition: Ldlr^Hlb301/Ldlr⁺ Genetic Background: C57BL/6J-Ldlr^Hlb301/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(H2-K-AKR1B1)1Tj/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 Allelic Composition: Ldlr^tm1Her/Ldlr⁺,Tg(H2-K-AKR1B1)1Tj/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * DBA/2 Allelic Composition: Esr1^tm1.1Mma/Esr1^tm1.1Mma,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd Allelic Composition: Esr1^tm1Arnal/Esr1^tm1Arnal,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nceh1^tm1Ishi/Nceh1^tm1Ishi Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lipe^tm1Ishi/Lipe^tm1Ishi Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lipe^tm1Ishi/Lipe^tm1Ishi,Nceh1^tm1Ishi/Nceh1^tm1Ishi Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J Allelic Composition: Cd1d1^tm1Luc/Cd1d1^tm1Luc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Cd1d1^tm1Luc Ldlr^tm1Her Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ins2^Akita/Ins2^Akita,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.Cg-Ins2^Akita Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0005340	altered susceptibility to atherosclerosis	"a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0005341	decreased susceptibility to atherosclerosis	"less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J Allelic Composition: Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs,Ldlr^tm1Her/Ldlr⁺ Genetic Background: involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(Il1rn)1Dih/Tg(Il1rn)1Dih Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Vcam1^tm1Dmil/Vcam1^tm1Dmil Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Icam1^tm1Jcgr/Icam1^tm1Jcgr,Ldlr^tm1Her/Ldlr^tm1Her,Vcam1^tm1Dmil/Vcam1^tm1Dmil Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Cxcl1^tm1Wabo/Cxcl1^tm1Wabo,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ath37^CAST/Ei/Ath37^CAST/Ei,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: CAST/Ei * C57BL/6J Allelic Composition: Ath38^CAST/Ei/Ath38^CAST/Ei,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: CAST/Ei * C57BL/6J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq6^CAST/EiJ/Mobq6^CAST/EiJ Genetic Background: B6.CAST-Mobq6^CAST/EiJ Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Olr1^tm1Meht/Olr1^tm1Meht Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APOM)NCchr/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA Allelic Composition: Alox15^tm1Fun/Alox15^tm1Fun,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ccl2^tm1Rol/Ccl2^tm1Rol,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Vwf^tm1Wgr/Vwf^tm1Wgr Genetic Background: B6.129S-Vwf^tm1Wgr Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tcra-J^tm1Tgi/Tcra-J^tm1Tgi Genetic Background: B6.129-Ldlr^tm1Her Tcra-J^tm1Tgi Allelic Composition: Ctss^tm1Hap/Ctss^tm1Hap,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Ctss^tm1Hap Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm3.1Sjns/Nr5a2^tm3.1Sjns Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N
MP:0005416	abnormal circulating protein level	"anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Vldlr^tm1Her/Vldlr^tm1Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
MP:0005449	abnormal food intake	"anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq6^CAST/EiJ/Mobq6^CAST/EiJ Genetic Background: B6.CAST-Mobq6^CAST/EiJ
MP:0005455	increased weight gain	"greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0005458	increased percent body fat	"more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0005459	decreased percent body fat	"less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0005551	abnormal eye electrophysiology	"abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Itgb3^tm1Hyn/Itgb3^tm1Hyn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
MP:0005595	abnormal vascular smooth muscle physiology	"anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mobq6^CAST/EiJ/Mobq6^CAST/EiJ Genetic Background: B6.CAST-Mobq6^CAST/EiJ
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S-Ldlr^tm1Her Del(11Cxcl16-Zmynd15)1Ifc
MP:0006058	decreased cerebral infarction size	"decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0006059	decreased susceptibility to ischemic brain injury	"decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0006116	aortic valve calcification	"pathologic deposition of calcium salts in the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0006117	aortic valve stenosis	"abnormal narrowing of the aortic valve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0006134	arterial occlusion	"blockage of blood flow through one or more arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0006238	abnormal choriocapillaris morphology	"malformation of the capillaries forming the inner vascular layer of the choroid of the eye" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006278	aortic aneurysm	"protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0006319	abnormal epididymal fat pad	"any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0008243	abnormal foam cell morphology	"any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Mapkapk2^tm1Mgl/Mapkapk2^tm1Mgl Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
MP:0008294	abnormal zona fasciculata morphology	"any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)" [MESH:A06.407.071.140.950]	Show Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0008428	abnormal spatial working memory	"anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0008431	abnormal short-term spatial reference memory	"anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encouter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008432	abnormal long-term spatial reference memory	"anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tg(APPSWE)2576Kha/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0008561	decreased tumor necrosis factor secretion	"reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tlr2^tm1Kir/Tlr2^tm1Kir Genetic Background: B6.129-Tlr2^tm1Kir Ldlr^tm1Her
MP:0008567	decreased interferon-gamma secretion	"reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tcra-J^tm1Tgi/Tcra-J^tm1Tgi Genetic Background: B6.129-Ldlr^tm1Her Tcra-J^tm1Tgi
MP:0008568	abnormal interleukin secretion	"anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tbx21^tm1Glm/Tbx21^tm1Glm Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
MP:0008571	abnormal synaptic bouton morphology	"any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008584	photoreceptor outer segment degeneration	"retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0008593	increased circulating interleukin-10 level	"increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Olr1^tm1Meht/Olr1^tm1Meht Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
MP:0008594	decreased circulating interleukin-10 level	"reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0008641	increased circulating interleukin-1 beta level	"increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Itgb3^tm1Hyn/Itgb3^tm1Hyn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0008874	decreased sensitivity to xenobiotics	"increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA
MP:0008900	abnormal uterine fat pad morphology	"any structural anomaly of the encapsulated adipose tissue associated with the uterus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0009355	increased liver triglyceride level	"higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr⁺,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0009538	abnormal synapse morphology	"any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Itgb3^tm1Hyn/Itgb3^tm1Hyn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
MP:0009858	abnormal cellular extravasation	"any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Tlr2^tm1Kir/Tlr2^tm1Kir Genetic Background: B6.129-Tlr2^tm1Kir Ldlr^tm1Her
MP:0009862	abnormal aorta elastic tissue morphology	"any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0009867	abnormal ascending aorta morphology	"any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Myh10^tm7Rsad/Myh10^tm7Rsad,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
MP:0010024	increased total body fat amount	"greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Ppara^tm1Gonz/Ppara^tm1Gonz Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
MP:0010026	decreased liver cholesterol level	"less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0010027	increased liver cholesterol level	"greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr⁺,Lep^ob/Lep^ob Genetic Background: B6.Cg-Lep^ob Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her/J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr1h3^tm1.1Djm/Nr1h3^tm1.1Djm,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 * DBA Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm3.1Sjns/Nr5a2^tm3.1Sjns Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N
MP:0010052	increased grip strength	"greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0010072	increased pruritus	"abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Apoa1^tm1Unc/Apoa1^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Apoa1^tm1Unc
MP:0010139	aortitis	"inflammation of the aorta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0010161	decreased brain cholesterol level	"less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Npc1^m1N/Npc1^m1N Genetic Background: involves: 129S7/SvEvBrd * BALB/c
MP:0010182	decreased susceptibility to weight gain	"smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129S7-Ldlr^tm1Her
MP:0010332	abnormal circulating apolipoprotein level	"anomaly in the amount in the blood of a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0010333	abnormal circulating apolipoprotein E level	"anomaly in the amount in the blood of a protein that is frequently a component of a VLDL, HDL, and chylomicron complexes, and functions in cholesterol transport" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0010574	aorta dilation	"the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0010659	abdominal aorta aneurysm	"a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0010661	ascending aorta aneurysm	"a protruding sac formed by the dilation of the wall of the of the part of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Myh10^tm7Rsad/Myh10^tm7Rsad,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Agtr1a^tm1Unc
MP:0010996	increased aorta wall thickness	"increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0010997	decreased aorta wall thickness	"decreased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Myh10^tm7Rsad/Myh10^tm7Rsad,Tg(Myh6-cre)2182Mds/0 Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N
MP:0011081	decreased macrophage apoptosis	"reduced incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gpr132^tm1Witt/Gpr132^tm1Witt,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Ldlr^tm1Her Gpr132^tm1Witt
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Fgg^tm1Fjc/Fgg^tm1Fjc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Fgg^tm1Fjc Apobec1^tm1Ddsn Ldlr^tm1Her
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Pfn1^tm1Wit/Pfn1⁺ Genetic Background: B6.129S-Ldlr^tm1Her Pfn1^tm1Wit
MP:0011572	abnormal aorta bulb morphology	"any structural anomaly of the portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles" [MGI:csmith, PMID:10722531]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0011579	decreased lipoprotein lipase activity	"reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate" [GO:0004465]	Show Allelic Composition: Lcat^tm1Hgc/Lcat^tm1Hgc,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-2J/Scd1^ab-2J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-2J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Scd1^ab-J/Scd1^ab-J Genetic Background: B6.Cg-Ldlr^tm1Her Scd1^ab-J
MP:0011951	increased cardiac stroke volume	"increase in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0012223	increased prothrombin level	"greater level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade" [MGI:csmith]	Show Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Apobec1^tm1Ddsn Ldlr^tm1Her
MP:0012224	abnormal sterol level	"anomaly in the level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated" [MGI:csmith]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Nr5a2^tm1Sjns/Nr5a2^tm1Sjns,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * C57BL/6J * DBA
MP:0012326	increased circulating antithrombin level	"higher than normal levels of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation" [ISBN:0-683-40008-8, MPD:Molly]	Show Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Apobec1^tm1Ddsn Ldlr^tm1Her
MP:0012355	decreased prothrombin time	"decreased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation" [MPD:Molly]	Show Allelic Composition: Apobec1^tm1Ddsn/Apobec1^tm1Ddsn,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: B6.129-Apobec1^tm1Ddsn Ldlr^tm1Her
MP:0012688	abnormal heart ventricles weight	"abnormal average weight of both the left and right ventricles together" [MPD:Molly]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
MP:0013277	abnormal fasted circulating glucose level	"any anomaly in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]	Show Allelic Composition: Apob^tm2Sgy/Apob^tm2Sgy,Ldlr^tm1Her/Ldlr^tm1Her,Tg(Ins-Igf2)1Fbos/? Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL
MP:0020332	impaired leukocyte tethering or rolling	"reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Vwf^tm1Wgr/Vwf^tm1Wgr Genetic Background: B6.129S-Vwf^tm1Wgr Ldlr^tm1Her

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr

ENSMUSG00000032193