Manteia - Molecule gene

ENSMUSG00000040249

Mus musculus

Features

Gene ID:	ENSMUSG00000040249

Biological name :	Lrp1

Synonyms :	LDL receptor related protein 1 / Lrp1

Possible biological names infered from orthology :	Q07954

Species:	Mus musculus

Chr. number:	10
Strand:	-1
Band:	D3
Gene start:	127538161
Gene end:	127621148

Corresponding Affymetrix probe sets:	10373223 (MoGene1.0st) 1442849_at (Mouse Genome 430 2.0 Array) 1448655_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000113584 Ensembl peptide - ENSMUSP00000120567 Ensembl peptide - ENSMUSP00000115305 Ensembl peptide - ENSMUSP00000044004 Ensembl peptide - ENSMUSP00000113497 NCBI entrez gene - 16971 See in Manteia. MGI - MGI:96828 RefSeq - NM_008512 RefSeq Peptide - NP_032538 swissprot - F6XU19 swissprot - D3Z5M3 swissprot - Q3U5J2 swissprot - A0A0R4J0I9 swissprot - F6UAC8 Ensembl - ENSMUSG00000040249

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lrp1aa	ENSDARG00000097827	Danio rerio
lrp1ab	ENSDARG00000029146	Danio rerio
LRP1	ENSG00000123384	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Lrp1b / LDL receptor related protein 1B / Q9NZR2*	ENSMUSG00000049252	60
Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*	ENSMUSG00000027070	37
Lrp4 / Q8VI56 / Low-density lipoprotein receptor-related protein 4 / O75096* / LDL receptor related protein 4*	ENSMUSG00000027253	15
Gm19410	ENSMUSG00000109372	13
Lrp5 / Q91VN0 / Low-density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*	ENSMUSG00000024913	12
Lrp6 / LDL receptor related protein 6 / O75581*	ENSMUSG00000030201	12
Ldlr / P35951 / Low-density lipoprotein receptor / P01130*	ENSMUSG00000032193	7
Vldlr / P98156 / very low density lipoprotein receptor / P98155*	ENSMUSG00000024924	7
Lrp8 / Q924X6 / Low-density lipoprotein receptor-related protein 8 / Q14114* / LDL receptor related protein 8*	ENSMUSG00000028613	7

Protein motifs (from Interpro)

Interpro ID	Name
IPR000033	LDLR class B repeat
IPR000152	EGF-type aspartate/asparagine hydroxylation site
IPR000742	EGF-like domain
IPR001881	EGF-like calcium-binding domain
IPR002172	Low-density lipoprotein (LDL) receptor class A repeat
IPR009030	Growth factor receptor cysteine-rich domain superfamily
IPR011042	Six-bladed beta-propeller, TolB-like
IPR013032	EGF-like, conserved site
IPR018097	EGF-like calcium-binding, conserved site
IPR023415	Low-density lipoprotein (LDL) receptor class A, conserved site
IPR026823	Complement Clr-like EGF domain
IPR032485	Domain of unknown function DUF5050
IPR036055	LDL receptor-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002265	astrocyte activation involved in immune response	IGI
biological_process	GO:0006898	receptor-mediated endocytosis	IMP
biological_process	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007568	aging	IEA
biological_process	GO:0008283	cell proliferation	IEA
biological_process	GO:0010942	positive regulation of cell death	IEA
biological_process	GO:0010977	negative regulation of neuron projection development	IEA
biological_process	GO:0021987	cerebral cortex development	IEA
biological_process	GO:0032092	positive regulation of protein binding	IEA
biological_process	GO:0042157	lipoprotein metabolic process	IEA
biological_process	GO:0043524	negative regulation of neuron apoptotic process	IEA
biological_process	GO:0045056	transcytosis	IEA
biological_process	GO:0045732	positive regulation of protein catabolic process	IDA
biological_process	GO:0045807	positive regulation of endocytosis	IEA
biological_process	GO:0051222	positive regulation of protein transport	IEA
biological_process	GO:0051246	regulation of protein metabolic process	IMP
biological_process	GO:0097242	amyloid-beta clearance	IEA
biological_process	GO:1900223	positive regulation of amyloid-beta clearance	IGI
biological_process	GO:1903078	positive regulation of protein localization to plasma membrane	IEA
biological_process	GO:1904646	cellular response to amyloid-beta	IGI
biological_process	GO:1905167	positive regulation of lysosomal protein catabolic process	IEA
cellular_component	GO:0005768	endosome	IEA
cellular_component	GO:0005769	early endosome	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0016323	basolateral plasma membrane	IEA
cellular_component	GO:0030136	clathrin-coated vesicle	IEA
cellular_component	GO:0030425	dendrite	IEA
cellular_component	GO:0043025	neuronal cell body	IEA
cellular_component	GO:0043235	receptor complex	IEA
molecular_function	GO:0002020	protease binding	IEA
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0016964	alpha-2 macroglobulin receptor activity	IEA
molecular_function	GO:0032050	clathrin heavy chain binding	IEA
molecular_function	GO:0034185	apolipoprotein binding	IEA
molecular_function	GO:0044877	protein-containing complex binding	IEA

Pathways (from Reactome)

Pathway description

Scavenging of heme from plasma

Retinoid metabolism and transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0000182	increased circulating LDL cholesterol level	"greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0000288	abnormal pericardium morphology	"malformation of the fibroserous membrane covering the heart and beginning of the great vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:54408]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0000598	abnormal liver morphology	"malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]	Show Allelic Composition: Nodal^tm1.1Mku/Nodal^tm2Mku,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129S1/Sv * C3H * C57BL/6
MP:0000606	decreased hepatocyte number	"fewer than normal number of parenchymal liver cells" [J:23170]	Show Allelic Composition: Nodal^tm1.1Mku/Nodal^tm2Mku,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129S1/Sv * C3H * C57BL/6
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0000746	weakness	"state of being infirm or less strong than littermates" [J:45400]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0000757	herniated abdominal wall	"protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Sod1^tm1Cep/Sod1^tm1Cep Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0001405	impaired coordination	"reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0001473	reduced long term potentiation	"less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0001504	abnormal posture	"atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0001512	trunk curl	"posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Sod1^tm1Cep/Sod1^tm1Cep Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0001524	impaired limb coordination	"reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0001547	abnormal lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0001556	increased circulating HDL cholesterol level	"higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]	Show Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0001570	abnormal circulating enzyme level	"aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL
MP:0001634	internal hemorrhage	"blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]	Show Allelic Composition: Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001697	abnormal embryo size	"anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0001777	abnormal body temperature regulation	"anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sod1^tm1Cep/Sod1^tm1Cep Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001780	decreased brown fat amount	"reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Sod1^tm1Cep/Sod1^tm1Cep Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0001798	impaired macrophage phagocytosis	"reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0001847	brain inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0001921	reduced fertility	"diminished ability to produce live offspring" [J:65030]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0002062	abnormal conditioning behavior	"inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her
MP:0002066	abnormal motor capabilities/coordination/movement	"altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sod1^tm1Cep/Sod1^tm1Cep Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Sod1^tm1Cep/Sod1^tm1Cep Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nodal^tm1.1Mku/Nodal^tm2Mku,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129S1/Sv * C3H * C57BL/6 Allelic Composition: Lrp1^tm1Ajmr/Lrp1^tm1Ajmr Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lrp1^tm6Ajmr/Lrp1^tm6Ajmr Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002229	CNS neurodegeneration	"a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0002702	decreased circulating free fatty acid level	"lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Sod1^tm1Cep/Sod1^tm1Cep Genetic Background: involves: 129S1/Sv * 129X1/SvJ
MP:0002727	decreased circulating insulin level	"less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0002753	dilated left ventricle	"an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0002795	dilated cardiomyopathy	"decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0002833	increased heart weight	"greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0003026	decreased vascular smooth muscle contraction	"reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her
MP:0003052	omphalocele	"protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0003075	response to CNS ischemic injury		Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003103	liver degeneration	"deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]	Show Allelic Composition: Nodal^tm1.1Mku/Nodal^tm2Mku,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129S1/Sv * C3H * C57BL/6
MP:0003329	amyloid beta deposits		Show Allelic Composition: T^24H/T⁺,t^h2/t⁺ Genetic Background: involves: 101/H * C3H/HeH
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: T^24H/T⁺,t^h2/t⁺ Genetic Background: involves: 101/H * C3H/HeH
MP:0003385	abnormal body wall	"malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0003633	abnormal nervous system physiology		Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0003691	abnormal microglial cell function	"anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0003924	herniated diaphragm	"protrusion of abdominal contents into the thoracic cavity through the diaphragm" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0003947	abnormal cholesterol level	"anomaly in the concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0003949	abnormal circulating lipid level	"anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004111	abnormal coronary artery morphology	"anomaly of any of the arteries that branch from the aorta to supply blood to the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0004254	cerebral amyloid angiopathy	"a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia" [acv:Alicia Valenzuela_Genetic Resources Curator]	Show Allelic Composition: T^24H/T⁺,t^h2/t⁺ Genetic Background: involves: 101/H * C3H/HeH
MP:0004263	abnormal limb posture	"atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0004883	abnormal blood vessel healing	"anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her
MP:0004889	increased energy expenditure	"increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0005145	increased circulating VLDL cholesterol level	"greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0005146	decreased circulating VLDL cholesterol level	"less than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0005178	increased total circulating cholesterol level	"greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0005179	decreased total circulating cholesterol level	"less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0005289	increased oxygen consumption	"greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005292	improved glucose tolerance	"better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005318	decreased triglyceride level	"lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0005334	abnormal fat pad	"malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005338	atherosclerotic lesions	"thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tdrd7^nmf166/Tdrd7^nmf166 Genetic Background: involves: C3H * C57BL/6J Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0005339	increased susceptibility to atherosclerosis	"more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0005385	cardiovascular system phenotype		Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0005416	abnormal circulating protein level	"anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Vldlr^tm1Her/Vldlr^tm1Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL Allelic Composition: Apoe^tm1Lmh/Apoe^tm1Lmh,Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0005452	abnormal body fat amount	"more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005595	abnormal vascular smooth muscle physiology	"anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her
MP:0005608	cardiac interstitial fibrosis	"formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0005650	abnormal limb bud morphology	"aberrant structure or development of any of the swellings on the trunk of the embryo that become limbs" [hdene:Howard Dene , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:61460]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005666	abnormal adipose tissue physiology	"functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0005668	decreased circulating leptin level	"less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0006047	aortic valve insufficiency	"the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0006058	decreased cerebral infarction size	"decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0006059	decreased susceptibility to ischemic brain injury	"decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
MP:0006134	arterial occlusion	"blockage of blood flow through one or more arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0006263	decreased diastolic blood pressure	"abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0006265	increased pulse pressure	"increase in the difference between systolic and diastolic blood pressure" [RGD:Rat Genome Database submission]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0006278	aortic aneurysm	"protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0008988	abnormal liver perisinusoidal space morphology	"any structural anomaly of the extravascular space in the liver between the parenchymal cells and a sinusoid that contains the blood plasma" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Nodal^tm1.1Mku/Nodal^tm2Mku,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129S1/Sv * C3H * C57BL/6
MP:0009116	abnormal brown fat cell morphology	"any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009133	decreased white fat cell size	"reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009136	decreased brown fat cell size	"reduction in the size of fat cells from the thermogenic form of adipose tissue" [MESH:A.10.165.114.322]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009137	decreased brown fat lipid droplet number	"reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009289	decreased epididymal fat pad weight		Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009295	decreased interscapular fat pad weight		Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0009454	impaired contextual conditioning	"decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0009456	impaired cued conditioning behavior	"decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0009538	abnormal synapse morphology	"any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0009642	abnormal blood homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009862	abnormal aorta elastic tissue morphology	"any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her
MP:0009865	abnormal aorta smooth muscle morphology	"any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her
MP:0009867	abnormal ascending aorta morphology	"any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0009873	abnormal aorta tunica media morphology	"any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: B6.Cg-Lrp1^tm2Her Tg(Tagln-cre)1Her
MP:0009936	abnormal dendritic spine morphology	"any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0010025	decreased total body fat amount	"less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0010161	decreased brain cholesterol level	"less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Camk2a-cre)T29-1Stl/0 Genetic Background: involves: 129S7/SvEvBrd * BALB/c * C57BL
MP:0010180	increased susceptibility to weight loss	"greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0010224	abnormal heart ventricle outflow tract morphology	"any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0010332	abnormal circulating apolipoprotein level	"anomaly in the amount in the blood of a protein that is frequently a component of a lipoprotein complex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Mx1-cre)29-4Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0010333	abnormal circulating apolipoprotein E level	"anomaly in the amount in the blood of a protein that is frequently a component of a VLDL, HDL, and chylomicron complexes, and functions in cholesterol transport" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her Genetic Background: involves: 129S7/SvEvBrd
MP:0010412	atrioventricular septal defect	"defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]	Show Allelic Composition: Megf8^b2b1702.2Clo/Megf8^b2b1702.2Clo Genetic Background: C57BL/6J-Megf8^b2b1702.2Clo
MP:0010470	ascending aorta dilation	"the luminal space of the ascending aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0010574	aorta dilation	"the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0010579	increased heart left ventricle size	"greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0010659	abdominal aorta aneurysm	"a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0010996	increased aorta wall thickness	"increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL
MP:0011015	decreased body surface temperature	"reduced degree of heat natural to skin-environment interface of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011049	impaired adaptive thermogenesis	"inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Nodal^tm1.1Mku/Nodal^tm2Mku,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129S1/Sv * C3H * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Aldh1a2^tm1Gdu/Aldh1a2^tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Lrp1^tm5Ajmr/Lrp1^tm5Ajmr Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0011109	partial lethality throughout fetal growth and development	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Nodal^tm1.1Mku/Nodal^tm2Mku,Tg(T-cre)1Lwd/0 Genetic Background: involves: 129S1/Sv * C3H * C57BL/6
MP:0011396	abnormal sleep behavior	"any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0011575	dilated aorta bulb	"the luminal space of the aorta bulb is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0011749	perivascular fibrosis	"invasion of fibrous connective tissue into the perivascular tissue, often resulting from inflammation or injury" [MGI:csmith]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0011925	abnormal heart echocardiography feature	"any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]	Show Allelic Composition: Gnas^tm5Lsw/Gnas^tm5Lsw,Tg(Fabp4-cre)1Abel/0 Genetic Background: involves: FVB
MP:0011939	increased food intake	"increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Ldlr^tm1Her/Ldlr^tm1Her,Lrp1^tm2Her/Lrp1^tm2Her,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6
MP:0013293	embryonic lethality prior to tooth bud stage	"death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0030021	increased muscle cell glucose uptake	"increased ability of muscle cells to take in glucose" [MGI:anna]	Show Allelic Composition: Lrp1^tm2Her/Lrp1^tm2Her,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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