ENSMUSG00000028613


Mus musculus

Features
Gene ID: ENSMUSG00000028613
  
Biological name :Lrp8
  
Synonyms : Low-density lipoprotein receptor-related protein 8 / Lrp8 / Q924X6
  
Possible biological names infered from orthology : LDL receptor related protein 8 / Q14114
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C7
Gene start: 107802261
Gene end: 107876840
  
Corresponding Affymetrix probe sets: 10506714 (MoGene1.0st)   1421459_a_at (Mouse Genome 430 2.0 Array)   1440882_at (Mouse Genome 430 2.0 Array)   1442347_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102343
Ensembl peptide - ENSMUSP00000102342
Ensembl peptide - ENSMUSP00000102344
Ensembl peptide - ENSMUSP00000118020
Ensembl peptide - ENSMUSP00000115854
Ensembl peptide - ENSMUSP00000030356
NCBI entrez gene - 16975     See in Manteia.
MGI - MGI:1340044
RefSeq - XM_017320004
RefSeq - XM_011240462
RefSeq - XM_011240463
RefSeq - XM_011240464
RefSeq - XM_011240465
RefSeq - XM_011240466
RefSeq - XM_011240467
RefSeq - XM_017320003
RefSeq - NM_001080926
RefSeq - XM_011240454
RefSeq - XM_011240455
RefSeq - XM_011240456
RefSeq - XM_011240457
RefSeq - XM_011240458
RefSeq - XM_011240459
RefSeq - XM_011240460
RefSeq - XM_011240461
RefSeq Peptide - NP_001074395
swissprot - B1AXJ5
swissprot - F6YZZ8
swissprot - B1AXJ6
swissprot - B1AXJ3
swissprot - Q924X6
swissprot - B1AXJ4
Ensembl - ENSMUSG00000028613
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrp8ENSDARG00000070074Danio rerio
 LRP8ENSGALG00000010692Gallus gallus
 LRP8ENSG00000157193Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Vldlr / P98156 / very low density lipoprotein receptor / P98155*ENSMUSG0000002492445
Ldlr / P35951 / Low-density lipoprotein receptor / P01130*ENSMUSG0000003219345
Lrp1b / LDL receptor related protein 1B / Q9NZR2*ENSMUSG0000004925234
Lrp1 / LDL receptor related protein 1 / Q07954*ENSMUSG0000004024934
Lrp2 / A2ARV4 / low density lipoprotein receptor-related protein 2 / P98164* / LDL receptor related protein 2*ENSMUSG0000002707033
Lrp4 / Q8VI56 / Low-density lipoprotein receptor-related protein 4 / O75096* / LDL receptor related protein 4*ENSMUSG0000002725330
Gm19410ENSMUSG0000010937224
Lrp5 / Q91VN0 / Low-density lipoprotein receptor-related protein 5 / O75197* / LDL receptor related protein 5*ENSMUSG0000002491319
Lrp6 / LDL receptor related protein 6 / O75581*ENSMUSG0000003020119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007268 chemical synaptic transmission IMP
 biological_processGO:0021517 ventral spinal cord development IEP
 biological_processGO:0021541 ammon gyrus development IMP
 biological_processGO:0021766 hippocampus development IGI
 biological_processGO:0021819 layer formation in cerebral cortex IGI
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity IMP
 biological_processGO:0038026 reelin-mediated signaling pathway IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IGI
 biological_processGO:0048813 dendrite morphogenesis IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0050804 modulation of chemical synaptic transmission IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IMP
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IMP
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:1900006 positive regulation of dendrite development IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005875 microtubule associated complex IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008035 high-density lipoprotein particle binding IEA
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0030229 very-low-density lipoprotein particle receptor activity IEA
 molecular_functionGO:0034185 apolipoprotein binding IDA
 molecular_functionGO:0038025 reelin receptor activity IMP
 molecular_functionGO:0048306 calcium-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
Platelet sensitization by LDL
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm2.1Her/Lrp8tm2.1Her
Genetic Background: involves: 129S6/SvEvTac

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her
Genetic Background: Not Specified

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000791 delaminated cerebral cortex "splitting of the layers of the gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:38857]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000792 abnormal cortical marginal zone morphology 
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her
Genetic Background: Not Specified

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her
Genetic Background: Not Specified

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

 MP:0000823 abnormal lateral ventricle morphology "malformation or absence of cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlr+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Lrp8tm2.1Her/Lrp8tm2.1Her
Genetic Background: involves: 129S6/SvEvTac

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her
Genetic Background: Not Specified

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her
Genetic Background: Not Specified

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Lrp8tm3Her/Lrp8tm3Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her
Genetic Background: Not Specified

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Thrbtm5Few/Thrb+
Genetic Background: involves: 129 * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lrp8tm2.1Her/Lrp8tm2.1Her
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Lrp8tm5Her/Lrp8tm5Her
Genetic Background: Not Specified

 MP:0004275 abnormal postnatal subventricular zone morphology "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hps3coa-8J/Hps3coa-8J
Genetic Background: C57BL/6J-Hps3coa-8J/GrsrJ

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlr+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: Lrp8tm4Her/Lrp8tm4Her
Genetic Background: Not Specified

Allelic Composition: Lrp8tm5Her/Lrp8tm5Her
Genetic Background: Not Specified

Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her
Genetic Background: Not Specified

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0009243 hairpin sperm flagellum "a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
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Allelic Composition: Lhcgrtm1Zmlei/Lhcgrtm1Zmlei
Genetic Background: either: 129X1/SvJ-Lhcgrtm1Zmlei or (involves: 129X1/SvJ * C57BL/6)

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Lrp8tm1Her/Lrp8tm1Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Lrp8tm4Her/Lrp8tm4Her,Vldlrtm1Her/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028874 Fgr / P14234 / Tyrosine-protein kinase Fgr / P09769* / FGR proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000002985 Apoe / P08226 / Apolipoprotein E / P02649*  / reaction






 

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