ENSMUSG00000028874


Mus musculus

Features
Gene ID: ENSMUSG00000028874
  
Biological name :Fgr
  
Synonyms : Fgr / P14234 / Tyrosine-protein kinase Fgr
  
Possible biological names infered from orthology : FGR proto-oncogene, Src family tyrosine kinase / P09769
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.3
Gene start: 132974095
Gene end: 133001910
  
Corresponding Affymetrix probe sets: 10508772 (MoGene1.0st)   1419526_at (Mouse Genome 430 2.0 Array)   1442804_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030693
Ensembl peptide - ENSMUSP00000128411
NCBI entrez gene - 14191     See in Manteia.
MGI - MGI:95527
RefSeq - XM_006538545
RefSeq - NM_010208
RefSeq - XM_006538544
RefSeq Peptide - NP_034338
swissprot - P14234
Ensembl - ENSMUSG00000028874
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGRENSG00000000938Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001984372
Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*ENSMUSG0000001493270
Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*ENSMUSG0000002764666
Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*ENSMUSG0000004222856
Hck / P08103 / Tyrosine-protein kinase HCK / P08631* / HCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000328356
Blk / P16277 / Tyrosine-protein kinase Blk / P51451* / BLK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001445354
Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000040952
Frk / Q922K9 / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA. / P42685* / fyn related Src family tyrosine kinase*ENSMUSG0000001977947
Srms / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSMUSG0000002757938
Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*ENSMUSG0000003875135


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035693  Tyrosine-protein kinase Fgr, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007229 integrin-mediated signaling pathway ISO
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization TAS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043306 positive regulation of mast cell degranulation IDA
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISO
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045088 regulation of innate immune response IMP
 biological_processGO:0045859 regulation of protein kinase activity IDA
 biological_processGO:0046777 protein autophosphorylation ISO
 biological_processGO:0050715 positive regulation of cytokine secretion IDA
 biological_processGO:0050764 regulation of phagocytosis IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome ISO
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0034987 immunoglobulin receptor binding IDA
 molecular_functionGO:0034988 Fc-gamma receptor I complex binding ISO


Pathways (from Reactome)
Pathway description
FCGR activation
Platelet sensitization by LDL
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Itgamtm1Myd/Itgamtm1Myd
Genetic Background: B6.129S4-Itgamtm1Myd

Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev,Lyntm1Sor/Lyntm1Sor
Genetic Background: B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc1tm1Glm/Nfatc1tm1Glm
Genetic Background: involves: 129S2/SvPas

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev,Lyntm1Sor/Lyntm1Sor
Genetic Background: B6.Cg-Hcktm1Hev Fgrtm1Hev Lyntm1Sor

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgrtm1Hev/Fgrtm1Hev,Hcktm1Hev/Hcktm1Hev
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008559 abnormal interferon-gamma secretion "anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Clnktm1Rygo/Clnktm1Rygo
Genetic Background: B6.129P2-Clnktm1Rygo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028613 Lrp8 / Q924X6 / Low-density lipoprotein receptor-related protein 8 / Q14114* / LDL receptor related protein 8*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr