ENSMUSG00000014932


Mus musculus

Features
Gene ID: ENSMUSG00000014932
  
Biological name :Yes1
  
Synonyms : Q04736 / Yes1 / YES proto-oncogene 1, Src family tyrosine kinase
  
Possible biological names infered from orthology : P07947
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 32611171
Gene end: 32687057
  
Corresponding Affymetrix probe sets: 10520965 (MoGene1.0st)   1418470_at (Mouse Genome 430 2.0 Array)   1449090_a_at (Mouse Genome 430 2.0 Array)   1456843_at (Mouse Genome 430 2.0 Array)   1458878_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072154
Ensembl peptide - ENSMUSP00000132161
Ensembl peptide - ENSMUSP00000144001
Ensembl peptide - ENSMUSP00000144355
NCBI entrez gene - 22612     See in Manteia.
MGI - MGI:99147
RefSeq - NM_001205132
RefSeq - NM_001205133
RefSeq - NM_009535
RefSeq Peptide - NP_001192061
RefSeq Peptide - NP_001192062
RefSeq Peptide - NP_033561
swissprot - Q3TJI7
swissprot - A0A0J9YUV2
swissprot - Q04736
Ensembl - ENSMUSG00000014932
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 yes1ENSDARG00000005941Danio rerio
 YES1ENSGALG00000014860Gallus gallus
 YES1ENSG00000176105Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*ENSMUSG0000002764673
Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001984373
Fgr / P14234 / Tyrosine-protein kinase Fgr / P09769* / FGR proto-oncogene, Src family tyrosine kinase*ENSMUSG0000002887467
Hck / P08103 / Tyrosine-protein kinase HCK / P08631* / HCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000328356
Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*ENSMUSG0000004222853
Lck / P06240 / Proto-onco tyrosine-protein kinase LCK / P06239* / LCK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000000040953
Blk / P16277 / Tyrosine-protein kinase Blk / P51451* / BLK proto-oncogene, Src family tyrosine kinase*ENSMUSG0000001445352
Frk / Q922K9 / Mus musculus fyn-related kinase (Frk), transcript variant 3, mRNA. / P42685* / fyn related Src family tyrosine kinase*ENSMUSG0000001977944
Srms / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites / Q9H3Y6*ENSMUSG0000002757935
Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*ENSMUSG0000003875134


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035751  Tyrosine-protein kinase Yes, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IDA
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0071300 cellular response to retinoic acid IDA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding ISO
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity ISO
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity IBA
 molecular_functionGO:0005102 signaling receptor binding IBA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0044325 ion channel binding ISO


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Srctm1Sor/Srctm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000523 cortical glomerulopathies "any disease of the capillary plexus in the kidney cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
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Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Srctm1Sor/Srctm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001951 abnormal breathing "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Srctm1Sor/Srctm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Srctm1Sor/Srctm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vipr2tm1Ajh/Vipr2tm1Ajh
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wnt7atm1Amc/Wnt7atm1Amc
Genetic Background: involves: 129S1/Sv

Allelic Composition: Yes1tm2Sor/Yes1tm2Sor
Genetic Background: either: 129S7/SvEvBrd-Yes1tm2Sor or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008478 increased spleen white pulp amount "increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Fyntm1Sor/Fyntm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Srctm1Sor/Srctm1Sor,Yes1tm1Sor/Yes1tm1Sor
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex
 ENSMUSG00000026259 Ngef / Q8CHT1 / Ephexin-1 / Q8N5V2* / neuronal guanine nucleotide exchange factor*  / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex






 

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