ENSMUSG00000032537


Mus musculus

Features
Gene ID: ENSMUSG00000032537
  
Biological name :Ephb1
  
Synonyms : Ephb1 / Ephrin type-B receptor 1 / Q8CBF3
  
Possible biological names infered from orthology : EPH receptor B1 / P54762
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F1
Gene start: 101922128
Gene end: 102354693
  
Corresponding Affymetrix probe sets: 10596095 (MoGene1.0st)   1455188_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035129
Ensembl peptide - ENSMUSP00000082261
Ensembl peptide - ENSMUSP00000139470
NCBI entrez gene - 270190     See in Manteia.
MGI - MGI:1096337
RefSeq - NM_001168296
RefSeq - NM_173447
RefSeq Peptide - NP_001161768
RefSeq Peptide - NP_775623
swissprot - Q8CA63
swissprot - Q8CBF3
Ensembl - ENSMUSG00000032537
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ephb1ENSDARG00000076757Danio rerio
 EPHB1ENSGALG00000006609Gallus gallus
 EPHB1ENSG00000154928Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*ENSMUSG0000002866473
Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*ENSMUSG0000000595871
Epha4 / Q03137 / Ephrin type-A receptor 4 / P54764* / EPH receptor A4*ENSMUSG0000002623558
Epha7 / Q61772 / Ephrin type-A receptor 7 / Q15375* / EPH receptor A7*ENSMUSG0000002828957
Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*ENSMUSG0000002971056
Epha3 / EPH receptor A3 / P29320*ENSMUSG0000005250455
Epha6 / EPH receptor A6 / Q9UF33*ENSMUSG0000005554054
Epha8 / O09127 / Ephrin type-A receptor 8 / P29322* / EPH receptor A8*ENSMUSG0000002866151
Ephb6 / O08644 / Ephrin type-B receptor 6 / EPH receptor B6*ENSMUSG0000002986948
Epha5 / Q60629 / Ephrin type-A receptor 5 / P54756* / EPH receptor A5*ENSMUSG0000002924548
Epha2 / Q03145 / Ephrin type-A receptor 2 ENSMUSG0000000644547
Epha1 / Q60750 / Ephrin type-A receptor 1 / P21709* / EPH receptor A1*ENSMUSG0000002985943


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001090  Ephrin receptor ligand binding domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001426  Tyrosine-protein kinase, receptor class V, conserved site
 IPR001660  Sterile alpha motif domain
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR008979  Galactose-binding-like domain superfamily
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR016257  Ephrin receptor type-A /type-B
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR027936  Ephrin receptor, transmembrane domain
 IPR034231  Ephrin type-B receptor 1, ligand binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis ISO
 biological_processGO:0001771 immunological synapse formation ISO
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0014719 skeletal muscle satellite cell activation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0021545 cranial nerve development IMP
 biological_processGO:0021631 optic nerve morphogenesis IMP
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IMP
 biological_processGO:0022008 neurogenesis IMP
 biological_processGO:0030010 establishment of cell polarity IMP
 biological_processGO:0031290 retinal ganglion cell axon guidance IDA
 biological_processGO:0031589 cell-substrate adhesion ISS
 biological_processGO:0046328 regulation of JNK cascade ISS
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048013 ephrin receptor signaling pathway ISS
 biological_processGO:0048593 camera-type eye morphogenesis IMP
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IMP
 biological_processGO:0051965 positive regulation of synapse assembly IMP
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0060996 dendritic spine development IMP
 biological_processGO:0060997 dendritic spine morphogenesis IMP
 biological_processGO:0061351 neural precursor cell proliferation IMP
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:1901214 regulation of neuron death ISO
 biological_processGO:1902723 negative regulation of skeletal muscle satellite cell proliferation IMP
 biological_processGO:1902725 negative regulation of satellite cell differentiation IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031901 early endosome membrane ISS
 cellular_componentGO:0032433 filopodium tip IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005003 ephrin receptor activity IEA
 molecular_functionGO:0005005 transmembrane-ephrin receptor activity ISS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008046 axon guidance receptor activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

 MP:0001332 abnormal optic nerve innervation "misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ephb1tm1Cmn/Ephb1tm2Cmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1tm2Cmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

Allelic Composition: Ephb1tm1Dgen/Ephb1+,Fezf2tm1Skm/Fezf2tm1Skm
Genetic Background: involves: 129

Allelic Composition: Ephb1tm1Dgen/Ephb1tm1Dgen,Fezf2tm1Skm/Fezf2+
Genetic Background: involves: 129

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae

 MP:0004267 abnormal optic tract morphology "any structural anomaly of the band of optic nerve fibers running from the optic chiasma to the lateral geniculate body and midbrain" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129/Sv * CD-1

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb1tm1.1Henk/Ephb1tm1.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm2Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm2Paw/Ephb2tm2Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

 MP:0008228 increased anterior commissure size "enlarged round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

Allelic Composition: Ephb1tm1Dgen/Ephb1tm1Dgen,Fezf2tm1Skm/Fezf2+
Genetic Background: involves: 129

 MP:0008960 abnormal axon pruning "defects in the developmental elimination of axons that fail to participate in an active neuronal circuit by retraction, degeneration, shedding or other mechanism" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax2tm1Pgr/Pax2tm1Pgr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Ephb1tm1Cmn/Ephb1tm1Cmn,Ephb2tm1Paw/Ephb2tm1Paw,Ephb3tm1Kln/Ephb3tm1Kln
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

 MP:0012462 decreased brain internal capsule size "reduced size of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

 MP:0012484 decreased corticospinal tract size "reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract" [ISBN:0-683-40008-8]
Show

Allelic Composition: Ephb1tm1Dgen/Ephb1tm1Dgen,Fezf2tm1Skm/Fezf2+
Genetic Background: involves: 129

 MP:0020140 increased brain external capsule size "larger than the normal physical proportions of the series of white matter fiber tracts in the brain that run between the most lateral segment of the lentiform nucleus and the claustrum" [ORCID: orcid.org/0000-0003-4606-0597, PMID:24997765]
Show

Allelic Composition: Il17rbtm1Hwata/Il17rb+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / complex / - / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / complex / reaction / -
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / - / complex / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / complex / reaction
 ENSMUSG00000011877 Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*  / complex / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / - / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction / - / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / - / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction / complex / -
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex
 ENSMUSG00000022261 Sdc2 / P43407 / Syndecan-2 / P34741*  / reaction
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000028249 Sdcbp / O08992 / syndecan binding protein / O00560*  / reaction / complex
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / complex
 ENSMUSG00000061751 Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / reaction / complex
 ENSMUSG00000021662 Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*  / reaction / complex
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex






 

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