ENSMUSG00000022261


Mus musculus

Features
Gene ID: ENSMUSG00000022261
  
Biological name :Sdc2
  
Synonyms : P43407 / Sdc2 / Syndecan-2
  
Possible biological names infered from orthology : P34741
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: B3.1
Gene start: 32920723
Gene end: 33034935
  
Corresponding Affymetrix probe sets: 10423548 (MoGene1.0st)   1417011_at (Mouse Genome 430 2.0 Array)   1417012_at (Mouse Genome 430 2.0 Array)   1431474_at (Mouse Genome 430 2.0 Array)   1448545_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022871
NCBI entrez gene - 15529     See in Manteia.
MGI - MGI:1349165
RefSeq - NM_008304
RefSeq Peptide - NP_032330
swissprot - P43407
Ensembl - ENSMUSG00000022261
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdc2ENSDARG00000002731Danio rerio
 SDC2ENSGALG00000031424Gallus gallus
 SDC2ENSG00000169439Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sdc3 / Q64519 / syndecan 3 / O75056*ENSMUSG0000002574339
Sdc4 / O35988 / syndecan 4 / P31431*ENSMUSG0000001700937
Sdc1 / P18828 / syndecan 1 / P18827*ENSMUSG0000002059234


Protein motifs (from Interpro)
Interpro ID Name
 IPR001050  Syndecan
 IPR003585  Neurexin/syndecan/glycophorin C
 IPR021157  Cytochrome c1, transmembrane anchor, C-terminal
 IPR027789  Syndecan/Neurexin domain
 IPR030479  Syndecan, conserved site
 IPR031201  Syndecan-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048814 regulation of dendrite morphogenesis IMP
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPHB-mediated forward signaling
Post-translational protein phosphorylation
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Scarb1tm1b(EUCOMM)Wtsi/Scarb1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Scarb1tm1b(EUCOMM)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction
 ENSMUSG00000022261 Sdc2 / P43407 / Syndecan-2 / P34741*  / -
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / reaction
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / reaction






 

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