ENSMUSG00000031217


Mus musculus

Features
Gene ID: ENSMUSG00000031217
  
Biological name :Efnb1
  
Synonyms : Efnb1 / Ephrin-B1 / P52795
  
Possible biological names infered from orthology : P98172
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: C3
Gene start: 99136130
Gene end: 99148991
  
Corresponding Affymetrix probe sets: 10600936 (MoGene1.0st)   1418285_at (Mouse Genome 430 2.0 Array)   1418286_a_at (Mouse Genome 430 2.0 Array)   1451591_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050716
NCBI entrez gene - 13641     See in Manteia.
MGI - MGI:102708
RefSeq - NM_010110
RefSeq Peptide - NP_034240
swissprot - P52795
swissprot - Q544L9
Ensembl - ENSMUSG00000031217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efnb1ENSDARG00000007723Danio rerio
 EFNB1ENSGALG00000036539Gallus gallus
 EFNB1ENSG00000090776Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efnb2 / P52800 / Ephrin-B2 / P52799*ENSMUSG0000000130051
Efnb3 / O35393 / Ephrin-B3 / Q15768*ENSMUSG0000000393437


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034255  Ephrin-B ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0009880 embryonic pattern specification IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IPI


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000030 abnormal tympanic ring morphology "malformed bony ring at the ear canal to which the tympanic membrane is attached" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Efnb1tm1Sor/Efnb1+,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

Allelic Composition: Efnb1tm1.1Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000107 abnormal frontal bone morphology "malformed bone forming the forehead and part of the eye orbit" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17489]
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Allelic Composition: Cacna1etm1Tsch/Cacna1etm1Tsch
Genetic Background: involves: C57BL/6

Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: CrygeNo3/CrygeNo3
Genetic Background: involves: 102/El * C3H/HeH

Allelic Composition: Efnb1tm1Rha/Efnb1tm1Rha
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1.1Rha/Efnb1tm1.1Rha
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Sor/Efnb1+,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Efnb1tm1.1Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000155 asymmetric rib attachment "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212]
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Allelic Composition: CrygeNo3/CrygeNo3
Genetic Background: involves: 102/El * C3H/HeH

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Prrx1-cre)1Cjt/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL/J

Allelic Composition: Efnb1tm1Sor/Efnb1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0000618 small salivary gland "reduced size of the saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Efnb1tm3.2Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm3.2Sor/Efnb1tm3.2Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm1.1Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001061 abnormal oculomotor nerve morphology "malformation or misprojection of the 3rd cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1.1Rha/Efnb1tm1.1Rha
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0002098 abnormal vibrissae morphology "irregular or unusual structure, appearance, or alignment of the vibrissae" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1etm1Tsch/Cacna1etm1Tsch
Genetic Background: involves: C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Efnb1tm3.2Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm3.2Sor/Efnb1+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm3.2Sor/Efnb1tm3.2Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm4.2Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm4.2Sor/Efnb1tm4.2Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm1.1Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm4.2Sor/Efnb1+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0003052 omphalocele "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1.1Rha/Efnb1tm1.1Rha
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004083 polysyndactyly "greater than 5 digits present on an autopod with interdigital webbing also present" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0004378 frontal bone foramen "presence of a hole in the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Efnb1tm1.1Sor/Efnb1+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Efnb1tm1.1Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0006322 abnormal perichondrium morphology "any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", J:117033, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb1tm1Sor/Efnb1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1.1Rha/Efnb1tm1.1Rha
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0008915 fused carpal bones "anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Efnb2tm2Sor/Efnb2tm2Sor
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Efnb1tm1.1Sor/Efnb1+,Efnb2tm2Sor/Efnb2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: CrygeNo3/CrygeNo3
Genetic Background: involves: 102/El * C3H/HeH

 MP:0009882 absent palatal shelf "absence of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate" [PMID:16680722]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Efnb1tm1Sor/Efnb1+,H2afvTg(Wnt1-cre)11Rth/?
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Efnb1tm1.1Sor/Y
Genetic Background: involves: 129S4/SvJaeSor

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: CrygeNo3/CrygeNo3
Genetic Background: involves: 102/El * C3H/HeH

Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0010133 increased DN3 thymocyte number "increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain." [CL:0000807]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0010136 decreased DN4 thymocyte number "reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive." [CL:0000808]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0010221 abnormal T-helper 17 cell differentiation "atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Heyltm1Kkb/Heyltm1Kkb
Genetic Background: B6.Cg-Hey1tm1Kkb Heyltm1Kkb

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Efnb1tm1Rha/Y,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Rha/Efnb1+,Tg(Pgk1-cre)1Lni/?
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

Allelic Composition: Efnb1tm1Sor/Y,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Efnb1tm1Sor/Efnb1tm1Sor,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Efnb1tm1Sor/Efnb1+,Meox2tm1(cre)Sor/Meox2+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: CrygeNo3/CrygeNo3
Genetic Background: involves: 102/El * C3H/HeH

Allelic Composition: Efnb1tm1Rha/Efnb1tm1Rha
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Efnb1tm1.1Rha/Efnb1tm1.1Rha
Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

 MP:0012752 abnormal cardiac neural crest cell migration "any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

 MP:0012757 abnormal cranial neural crest cell migration "any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage" [MGI:anna]
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Allelic Composition: Fhittm1Tko/Fhit+
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / - / complex / reaction
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex / -
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000011877 Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*  / reaction / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex / - / reaction
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000028249 Sdcbp / O08992 / syndecan binding protein / O00560*  / complex / reaction
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / reaction / complex
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / - / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / reaction / complex / -
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex / - / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction / -
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex
 ENSMUSG00000022261 Sdc2 / P43407 / Syndecan-2 / P34741*  / reaction
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / complex
 ENSMUSG00000061751 Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction
 ENSMUSG00000021662 Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*  / complex / reaction
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex / reaction






 

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