ENSMUSG00000028249


Mus musculus

Features
Gene ID: ENSMUSG00000028249
  
Biological name :Sdcbp
  
Synonyms : O08992 / Sdcbp / syndecan binding protein
  
Possible biological names infered from orthology : O00560
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 6365650
Gene end: 6408423
  
Corresponding Affymetrix probe sets: 10503134 (MoGene1.0st)   1423332_at (Mouse Genome 430 2.0 Array)   1430528_at (Mouse Genome 430 2.0 Array)   1450941_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104011
Ensembl peptide - ENSMUSP00000135777
Ensembl peptide - ENSMUSP00000122411
Ensembl peptide - ENSMUSP00000119838
Ensembl peptide - ENSMUSP00000029912
Ensembl peptide - ENSMUSP00000100073
NCBI entrez gene - 53378     See in Manteia.
MGI - MGI:1337026
RefSeq - XM_006538084
RefSeq - NM_001098227
RefSeq - NM_016807
RefSeq Peptide - NP_058087
RefSeq Peptide - NP_001091697
swissprot - A2AKJ9
swissprot - O08992
swissprot - A2AKJ5
swissprot - A2AKJ6
swissprot - H3BLG5
swissprot - Q3TMX0
Ensembl - ENSMUSG00000028249
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sdcbpENSDARG00000030097Danio rerio
 SDCBPENSGALG00000015436Gallus gallus
 SDCBPENSG00000137575Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99JZ0 / Sdcbp2 / Syntenin-2 / Q9H190* / syndecan binding protein 2*ENSMUSG0000002745658


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR030528  Syntenin-1
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002091 negative regulation of receptor internalization ISO
 biological_processGO:0007265 Ras protein signal transduction IPI
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0007346 regulation of mitotic cell cycle ISS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition ISO
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0030307 positive regulation of cell growth IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042327 positive regulation of phosphorylation ISO
 biological_processGO:1903543 positive regulation of exosomal secretion ISO
 biological_processGO:1903553 positive regulation of extracellular exosome assembly ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005895 interleukin-5 receptor complex IMP
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005109 frizzled binding ISO
 molecular_functionGO:0005137 interleukin-5 receptor binding IMP
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISO
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0042043 neurexin family protein binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0045545 syndecan binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Ephrin signaling
Neurofascin interactions
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Morc1Tg(Tyr)1Az/Morc1Tg(Tyr)1Az
Genetic Background: involves: C57BL/6N * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026442 Nfasc / Q810U3 / Neurofascin / O94856*  / complex / reaction
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex / reaction
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / reaction / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / reaction / complex
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr