ENSMUSG00000003934


Mus musculus

Features
Gene ID: ENSMUSG00000003934
  
Biological name :Efnb3
  
Synonyms : Efnb3 / Ephrin-B3 / O35393
  
Possible biological names infered from orthology : Q15768
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69554092
Gene end: 69560205
  
Corresponding Affymetrix probe sets: 10387483 (MoGene1.0st)   1423085_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004036
NCBI entrez gene - 13643     See in Manteia.
MGI - MGI:109196
RefSeq - XM_006532160
RefSeq - NM_007911
RefSeq Peptide - NP_031937
swissprot - O35393
swissprot - Q543Q7
Ensembl - ENSMUSG00000003934
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efnb3aENSDARG00000112993Danio rerio
 efnb3bENSDARG00000042277Danio rerio
 EFNB3ENSG00000108947Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efnb2 / P52800 / Ephrin-B2 / P52799*ENSMUSG0000000130040
Efnb1 / P52795 / Ephrin-B1 / P98172*ENSMUSG0000003121738


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034255  Ephrin-B ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007628 adult walking behavior IMP
 biological_processGO:0016198 axon choice point recognition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031295 T cell costimulation IDA
 biological_processGO:0048013 ephrin receptor signaling pathway ISO
 biological_processGO:0050771 negative regulation of axonogenesis IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding ISO


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHB-mediated forward signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000940 abnormal motor neuron innervation "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Efnb3tm1Nwg/Efnb3tm1Nwg
Genetic Background: involves: C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

Allelic Composition: Efnb3lltw/Efnb3lltw
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mc4rGlu3/Mc4r+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Efnb3tm1Henk/Efnb3tm1Henk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Efnb3tm1Nwg/Efnb3tm1Nwg
Genetic Background: involves: C57BL/6

Allelic Composition: Efnb3tm2Henk/Efnb3tm2Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Efnb3tm3Henk/Efnb3tm3Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Apobec2tm1Msn/Apobec2tm1Msn
Genetic Background: B6.129P2-Apobec2tm1Msn

Allelic Composition: Efnb3lltw/Efnb3lltw
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: C57BL/6

 MP:0001898 abnormal long term depression "change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Epha4tm1Byd/Epha4tm1Byd
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Efnb3tm1Henk/Efnb3tm1Henk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Efnb3tm1.2Henk/Efnb3tm1.2Henk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Efnb3tm1Henk/Efnb3tm1Henk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd3etm1Mal/Cd3etm1Mal,Nlrp1aNeut1/Nlrp1aNeut1
Genetic Background: involves: C57BL/6

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Chrnetm1Vwi/Chrnetm1Vwi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Efnb3tm1Henk/Efnb3tm1Henk
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Efnb3tm1Nwg/Efnb3tm1Nwg
Genetic Background: involves: C57BL/6

 MP:0003880 abnormal central pattern generator function "anomalous function of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:101019]
Show

Allelic Composition: Efnb3tm1Nwg/Efnb3tm1Nwg
Genetic Background: involves: C57BL/6

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Efnb3tm3Henk/Efnb3tm3Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Efnb3tm3.1Henk/Efnb3tm3.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Efnb3tm1.1Henk/Efnb3tm1.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Efnb3tm1Henk/Efnb3tm1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0008960 abnormal axon pruning "defects in the developmental elimination of axons that fail to participate in an active neuronal circuit by retraction, degeneration, shedding or other mechanism" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Efnb3tm3Henk/Efnb3tm3Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Efnb3tm3.1Henk/Efnb3tm3.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Efnb3tm1.1Henk/Efnb3tm1.1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Efnb3tm1Henk/Efnb3tm1Henk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Efnb3lltw/Efnb3lltw
Genetic Background: involves: C3H/HeSnJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042228 Lyn / P25911 / LYN proto-oncogene, Src family tyrosine kinase / P07948*  / complex
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / - / complex
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / complex / - / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / - / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / complex / reaction / -
 ENSMUSG00000022261 Sdc2 / P43407 / Syndecan-2 / P34741*  / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / - / reaction / complex
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / - / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000014932 Yes1 / Q04736 / YES proto-oncogene 1, Src family tyrosine kinase / P07947*  / complex
 ENSMUSG00000030209 Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*  / complex
 ENSMUSG00000026959 Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*  / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex / reaction / -
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction / complex
 ENSMUSG00000011877 Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*  / complex / reaction
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000028249 Sdcbp / O08992 / syndecan binding protein / O00560*  / reaction / complex
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex / reaction
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000022957 Itsn1 / Q9Z0R4 / Intersectin-1 / Q15811*  / complex
 ENSMUSG00000061751 Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*  / reaction / complex
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction
 ENSMUSG00000021662 Arhgef28 / Rho guanine nucleotide exchange factor 28 / Q8N1W1*  / complex / reaction
 ENSMUSG00000021549 Rasa1 / RAS p21 protein activator 1 / P20936*  / complex






 

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