ENSMUSG00000031511


Mus musculus

Features
Gene ID: ENSMUSG00000031511
  
Biological name :Arhgef7
  
Synonyms : Arhgef7 / Q9ES28 / Rho guanine nucleotide exchange factor 7
  
Possible biological names infered from orthology : Q14155
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 11727721
Gene end: 11835219
  
Corresponding Affymetrix probe sets: 10570144 (MoGene1.0st)   1424482_at (Mouse Genome 430 2.0 Array)   1449066_a_at (Mouse Genome 430 2.0 Array)   1458969_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000096538
Ensembl peptide - ENSMUSP00000106529
Ensembl peptide - ENSMUSP00000148111
Ensembl peptide - ENSMUSP00000148109
Ensembl peptide - ENSMUSP00000147641
Ensembl peptide - ENSMUSP00000106534
Ensembl peptide - ENSMUSP00000074399
NCBI entrez gene - 54126     See in Manteia.
MGI - MGI:1860493
RefSeq - XM_006508841
RefSeq - XM_017312901
RefSeq - XM_006508845
RefSeq - XM_006508844
RefSeq - XM_006508843
RefSeq - NM_001113517
RefSeq - NM_001113518
RefSeq - NM_017402
RefSeq Peptide - NP_001106989
RefSeq Peptide - NP_001106990
RefSeq Peptide - NP_059098
swissprot - Q9ES28
swissprot - D3Z0V2
swissprot - A0A0R4J0X8
swissprot - A0A1B0GRS3
swissprot - A0A1B0GSX2
swissprot - A0A1B0GSX4
Ensembl - ENSMUSG00000031511
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef7aENSDARG00000006299Danio rerio
 arhgef7bENSDARG00000073848Danio rerio
 ARHGEF7ENSGALG00000031009Gallus gallus
 Q14155ENSG00000102606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG0000003113354
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG0000000248918
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG0000002380018
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG0000003962116
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199016
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG0000004896015
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG0000003411615
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG0000003372114
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG0000000962114
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG0000002565613
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG0000003750913


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR032409  Rho guanine nucleotide exchange factor, coiled-coil domain
 IPR035789  Rho guanine nucleotide exchange factor 7, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0007030 Golgi organization ISO
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043547 positive regulation of GTPase activity HMP
 biological_processGO:0060124 positive regulation of growth hormone secretion IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1904424 regulation of GTP binding ISO
 cellular_componentGO:0000322 storage vacuole IDA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection ISO
 cellular_componentGO:0043025 neuronal cell body ISO
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
EGFR downregulation
NRAGE signals death through JNK
Rho GTPase cycle
Ephrin signaling
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Aff3tm1a(EUCOMM)Wtsi/Aff3+
Genetic Background: C57BL/6N-Aff3tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000011877 Git1 / Q68FF6 / ARF GTPase-activating protein GIT1 / Q9Y2X7* / GIT ArfGAP 1*  / complex / reaction
 ENSMUSG00000003934 Efnb3 / O35393 / Ephrin-B3 / Q15768*  / reaction / complex
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000005958 Ephb3 / P54754 / Ephrin type-B receptor 3 / P54753* / EPH receptor B3*  / reaction / complex
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex
 ENSMUSG00000034342 Cbl / P22682 / E3 ubiquitin-protein ligase CBL / P22681* / Cbl proto-oncogene*  / complex
 ENSMUSG00000028017 Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*  / complex
 ENSMUSG00000032537 Ephb1 / Q8CBF3 / Ephrin type-B receptor 1 / P54762* / EPH receptor B1*  / complex / reaction
 ENSMUSG00000001300 Efnb2 / P52800 / Ephrin-B2 / P52799*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000028664 Ephb2 / P54763 / Ephrin type-B receptor 2 / P29323* / EPH receptor B2*  / complex / reaction
 ENSMUSG00000031217 Efnb1 / P52795 / Ephrin-B1 / P98172*  / complex / reaction
 ENSMUSG00000029710 Ephb4 / P54761 / Ephrin type-B receptor 4 / P54760* / EPH receptor B4*  / reaction / complex
 ENSMUSG00000031511 Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*  / complex
 ENSMUSG00000020122 Egfr / Q01279 / Epidermal growth factor receptor / P00533*  / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction






 

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