ENSMUSG00000023800


Mus musculus

Features
Gene ID: ENSMUSG00000023800
  
Biological name :Tiam2
  
Synonyms : Q6ZPF3 / Tiam2 / T-lymphoma invasion and metastasis-inducing protein 2
  
Possible biological names infered from orthology : Q8IVF5 / T cell lymphoma invasion and metastasis 2
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A1
Gene start: 3326573
Gene end: 3531344
  
Corresponding Affymetrix probe sets: 10441361 (MoGene1.0st)   1420146_at (Mouse Genome 430 2.0 Array)   1423186_at (Mouse Genome 430 2.0 Array)   1431222_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072020
Ensembl peptide - ENSMUSP00000125842
Ensembl peptide - ENSMUSP00000154598
Ensembl peptide - ENSMUSP00000154627
NCBI entrez gene - 24001     See in Manteia.
MGI - MGI:1344338
RefSeq - XM_006523226
RefSeq - NM_001122998
RefSeq - NM_011878
RefSeq - XM_006523225
RefSeq Peptide - NP_001116470
RefSeq Peptide - NP_036008
swissprot - Q6ZPF3
Ensembl - ENSMUSG00000023800
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tiam2aENSDARG00000087780Danio rerio
 tiam2bENSDARG00000098233Danio rerio
 TIAM2ENSGALG00000036005Gallus gallus
 TIAM2ENSG00000146426Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG0000000248937
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199011
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG000000337218
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG000000396218
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG000000489608
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG000000315118
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG000000341168
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG000000311338
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG000000096217
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG000000256566
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG000000375096


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR003116  Raf-like Ras-binding
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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