ENSMUSG00000002489


Mus musculus

Features
Gene ID: ENSMUSG00000002489
  
Biological name :Tiam1
  
Synonyms : T cell lymphoma invasion and metastasis 1 / Tiam1
  
Possible biological names infered from orthology : Q13009
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.3
Gene start: 89787111
Gene end: 89980080
  
Corresponding Affymetrix probe sets: 10440738 (MoGene1.0st)   1418057_at (Mouse Genome 430 2.0 Array)   1444373_at (Mouse Genome 430 2.0 Array)   1453887_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000132137
Ensembl peptide - ENSMUSP00000136283
Ensembl peptide - ENSMUSP00000137637
Ensembl peptide - ENSMUSP00000002588
Ensembl peptide - ENSMUSP00000109757
Ensembl peptide - ENSMUSP00000109759
Ensembl peptide - ENSMUSP00000126020
NCBI entrez gene - 21844     See in Manteia.
MGI - MGI:103306
RefSeq - XM_017316936
RefSeq - XM_011246112
RefSeq - XM_006522978
RefSeq - XM_006522983
RefSeq - XM_006522982
RefSeq - NM_001145886
RefSeq - NM_001145887
RefSeq - NM_009384
RefSeq - XM_006522980
RefSeq Peptide - NP_001139358
RefSeq Peptide - NP_001139359
RefSeq Peptide - NP_033410
swissprot - E9Q2Y4
swissprot - E9Q1R7
swissprot - J3QQ55
swissprot - J3QMH1
swissprot - G3UWG2
Ensembl - ENSMUSG00000002489
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tiam1aENSDARG00000078430Danio rerio
 tiam1bENSDARG00000025920Danio rerio
 TIAM1ENSGALG00000015842Gallus gallus
 TIAM1ENSG00000156299Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG0000002380040
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199013
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG000000315119
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG000000311338
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG000000337218
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG000000396218
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG000000341168
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG000000375097
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG000000256567
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG000000096217
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG000000489607


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR003116  Raf-like Ras-binding
 IPR011993  PH-like domain superfamily
 IPR033360  T-lymphoma invasion and metastasis-inducing protein 1
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:0098989 NMDA selective glutamate receptor signaling pathway IEA
 biological_processGO:1904268 positive regulation of Schwann cell chemotaxis IEA
 biological_processGO:1905274 regulation of modification of postsynaptic actin cytoskeleton IEA
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044291 cell-cell contact zone IEA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0044304 main axon IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
Show

Allelic Composition: Spaca1tm1.1Osb/Spaca1tm1.1Osb,Tg(Acr-EGFP)1Osb/0
Genetic Background: involves: 129S2/SvPas * C3H * C57BL * C57BL/6 * DBA

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Thbs2tm1Bst/Thbs2tm1Bst
Genetic Background: either: (involves: 129S4/SvJae * 129X1/SvJ) or (involves: 129X1/SvJ)

Allelic Composition: Tiam1tm1Jgc/Tiam1+
Genetic Background: involves: 129P2/OlaHsd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr