ENSG00000156299


Homo sapiens

Features
Gene ID: ENSG00000156299
  
Biological name :TIAM1
  
Synonyms : Q13009 / T cell lymphoma invasion and metastasis 1 / TIAM1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 21
Strand: -1
Band: q22.11
Gene start: 31118416
Gene end: 31559977
  
Corresponding Affymetrix probe sets: 206409_at (Human Genome U133 Plus 2.0 Array)   213135_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000490786
Ensembl peptide - ENSP00000388217
Ensembl peptide - ENSP00000393384
Ensembl peptide - ENSP00000441570
Ensembl peptide - ENSP00000286827
NCBI entrez gene - 7074     See in Manteia.
OMIM - 600687
RefSeq - XM_017028453
RefSeq - NM_003253
RefSeq - XM_005261037
RefSeq - XM_005261038
RefSeq - XM_005261040
RefSeq - XM_011529711
RefSeq - XM_011529712
RefSeq - XM_011529713
RefSeq - XM_017028447
RefSeq - XM_017028448
RefSeq - XM_017028449
RefSeq - XM_017028450
RefSeq - XM_017028451
RefSeq - XM_017028452
RefSeq - NM_001353684
RefSeq - NM_001353689
RefSeq - NM_001353690
RefSeq - NM_001353691
RefSeq - NM_001353692
RefSeq - NM_001353693
RefSeq - NM_001353694
RefSeq Peptide - NP_001340618
RefSeq Peptide - NP_001340623
RefSeq Peptide - NP_003244
RefSeq Peptide - NP_001340613
RefSeq Peptide - NP_001340617
RefSeq Peptide - NP_001340619
RefSeq Peptide - NP_001340620
RefSeq Peptide - NP_001340621
RefSeq Peptide - NP_001340622
swissprot - H7C079
swissprot - Q13009
swissprot - A0A1B0GW57
swissprot - C9JMB5
Ensembl - ENSG00000156299
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tiam1aENSDARG00000078430Danio rerio
 tiam1bENSDARG00000025920Danio rerio
 TIAM1ENSGALG00000015842Gallus gallus
 Tiam1ENSMUSG00000002489Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TIAM2 / Q8IVF5 / T cell lymphoma invasion and metastasis 2ENSG0000014642640
Q96N96 / SPATA13 / spermatogenesis associated 13ENSG0000018295712
AL359736.1ENSG0000027316711
Q9NR80 / ARHGEF4 / Rho guanine nucleotide exchange factor 4ENSG000001360029
PREX1 / Q8TCU6 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1ENSG000001241268
Q15052 / ARHGEF6 / Rac/Cdc42 guanine nucleotide exchange factor 6ENSG000001296758
VAV1 / P15498 / vav guanine nucleotide exchange factor 1ENSG000001419688
VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3ENSG000001342158
Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7ENSG000001026068
PREX2 / Q70Z35 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2ENSG000000468897
VAV2 / P52735 / vav guanine nucleotide exchange factor 2ENSG000001602937
O43307 / ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9ENSG000001310897


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR003116  Raf-like Ras-binding
 IPR011993  PH-like domain superfamily
 IPR033360  T-lymphoma invasion and metastasis-inducing protein 1
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007160 cell-matrix adhesion IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IDA
 biological_processGO:0010718 positive regulation of epithelial to mesenchymal transition NAS
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0016601 Rac protein signal transduction IMP
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0050772 positive regulation of axonogenesis IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072657 protein localization to membrane IEA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:0098989 NMDA selective glutamate receptor signaling pathway IEA
 biological_processGO:1904268 positive regulation of Schwann cell chemotaxis IEA
 biological_processGO:1904338 regulation of dopaminergic neuron differentiation ISS
 biological_processGO:1905274 regulation of modification of postsynaptic actin cytoskeleton IEA
 biological_processGO:1990138 neuron projection extension IEA
 biological_processGO:2000050 regulation of non-canonical Wnt signaling pathway ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0036477 somatodendritic compartment IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0044295 axonal growth cone IEA
 cellular_componentGO:0044304 main axon IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0017016 Ras GTPase binding IEA
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
G alpha (12/13) signalling events
Activated NTRK2 signals through CDK5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000176697 BDNF / P23560 / brain derived neurotrophic factor  / complex / reaction
 ENSG00000176884 GRIN1 / Q05586 / glutamate ionotropic receptor NMDA type subunit 1  / complex / reaction
 ENSG00000254087 LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000148053 NTRK2 / Q16620 / neurotrophic receptor tyrosine kinase 2  / complex / reaction
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000273079 GRIN2B / Q13224 / glutamate ionotropic receptor NMDA type subunit 2B  / complex / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / reaction / complex
 ENSG00000176105 YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinase  / complex / reaction






 

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