ENSG00000124126


Homo sapiens

Features
Gene ID: ENSG00000124126
  
Biological name :PREX1
  
Synonyms : phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / PREX1 / Q8TCU6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.13
Gene start: 48624252
Gene end: 48827883
  
Corresponding Affymetrix probe sets: 224909_s_at (Human Genome U133 Plus 2.0 Array)   224925_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361009
Ensembl peptide - ENSP00000481444
Ensembl peptide - ENSP00000434632
NCBI entrez gene - 57580     See in Manteia.
OMIM - 606905
RefSeq - NM_020820
RefSeq - XM_011528934
RefSeq Peptide - NP_065871
swissprot - A0A087WY11
swissprot - Q8TCU6
swissprot - H0YDZ4
Ensembl - ENSG00000124126
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prex1ENSDARG00000075793Danio rerio
 PREX1ENSGALG00000004621Gallus gallus
 Prex1ENSMUSG00000039621Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PREX2 / Q70Z35 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2ENSG0000004688956
Q9NR80 / ARHGEF4 / Rho guanine nucleotide exchange factor 4ENSG0000013600211
Q96N96 / SPATA13 / spermatogenesis associated 13ENSG0000018295710
VAV2 / P52735 / vav guanine nucleotide exchange factor 2ENSG000001602939
VAV1 / P15498 / vav guanine nucleotide exchange factor 1ENSG000001419689
O43307 / ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9ENSG000001310899
TIAM2 / Q8IVF5 / T cell lymphoma invasion and metastasis 2ENSG000001464269
VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3ENSG000001342159
AL359736.1ENSG000002731678
Q15052 / ARHGEF6 / Rac/Cdc42 guanine nucleotide exchange factor 6ENSG000001296758
TIAM1 / Q13009 / T cell lymphoma invasion and metastasis 1ENSG000001562998
Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7ENSG000001026067


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000591  DEP domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0006801 superoxide metabolic process TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0030041 actin filament polymerization TAS
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042119 neutrophil activation TAS
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0050773 regulation of dendrite development IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0019899 enzyme binding TAS
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IBA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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