ENSDARG00000075793


Danio rerio

Features
Gene ID: ENSDARG00000075793
  
Biological name :prex1
  
Synonyms : phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 / prex1
  
Possible biological names infered from orthology : Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q69ZK0 / Q8TCU6
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 25423133
Gene end: 25569920
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000117063
Ensembl peptide - ENSDARP00000117163
Ensembl peptide - ENSDARP00000072486
NCBI entrez gene - 570984     See in Manteia.
swissprot - B0UYE5
swissprot - F1QQK7
swissprot - F1R6J2
ZFIN ID - ZDB-GENE-030131-1428
Ensembl - ENSDARG00000075793
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PREX1ENSGALG00000004621Gallus gallus
 PREX1ENSG00000124126Homo sapiens
 Prex1ENSMUSG00000039621Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prex2 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSDARG0000007169254
arhgef4 / Rho guanine nucleotide exchange factor (GEF) 4 / Q7TNR9* / Q9NR80* / Rho guanine nucleotide exchange factor 4*ENSDARG0000001291410
spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSDARG000000628379
arhgef9b / Cdc42 guanine nucleotide exchange factor (GEF) 9b / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG000000786249
arhgef9a / Cdc42 guanine nucleotide exchange factor (GEF) 9a / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG000000617468
arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG000000062998
vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSDARG000000447188
vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*ENSDARG000000759628
arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG000000738487
tiam1b / T cell lymphoma invasion and metastasis 1b / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG000000259207
arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSDARG000000066837
tiam2a / T cell lymphoma invasion and metastasis 2a / TIAM2* / Q8IVF5* / Q6ZPF3* / T cell lymphoma invasion and metastasis 2* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSDARG000000877807
tiam1a / T cell lymphoma invasion and metastasis 1a / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG000000784307
tiam2b / T cell lymphoma invasion and metastasis 2b / TIAM2* / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSDARG000000982336
si:ch73-383g2.1ENSDARG000000571073
vav3a / vav 3 guanine nucleotide exchange factor aENSDARG000000866232
si:dkey-21o19.2ENSDARG000000889002
CABZ01114581.1ENSDARG000001125260


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000591  DEP domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0038092 nodal signaling pathway IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IBA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0009139 endodermal cell endodermal cell cellular motility , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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