ENSDARG00000078624


Danio rerio

Features
Gene ID: ENSDARG00000078624
  
Biological name :arhgef9b
  
Synonyms : arhgef9b / Cdc42 guanine nucleotide exchange factor (GEF) 9b
  
Possible biological names infered from orthology : ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307 / Q3UTH8 / Rho guanine nucleotide exchange factor 9
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 9142162
Gene end: 9199968
  
Corresponding Affymetrix probe sets: Dr.6315.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000115968
NCBI entrez gene - 560923     See in Manteia.
RefSeq - NM_001161663
RefSeq - XM_021481030
RefSeq Peptide - NP_001155135
swissprot - F1Q628
ZFIN ID - ZDB-GENE-030131-7745
Ensembl - ENSDARG00000078624
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF9ENSGALG00000007608Gallus gallus
 O43307ENSG00000131089Homo sapiens
 Q3UTH8ENSMUSG00000025656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef9a / Cdc42 guanine nucleotide exchange factor (GEF) 9a / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG0000006174684
arhgef4 / Rho guanine nucleotide exchange factor (GEF) 4 / Q7TNR9* / Q9NR80* / Rho guanine nucleotide exchange factor 4*ENSDARG0000001291459
spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSDARG0000006283754
prex1 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSDARG0000007579327
prex2 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSDARG0000007169226
arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG0000007384820
tiam1a / T cell lymphoma invasion and metastasis 1a / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG0000007843020
arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSDARG0000000668320
tiam1b / T cell lymphoma invasion and metastasis 1b / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG0000002592020
arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG0000000629919
vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*ENSDARG0000007596218
tiam2a / T cell lymphoma invasion and metastasis 2a / TIAM2* / Q8IVF5* / Q6ZPF3* / T cell lymphoma invasion and metastasis 2* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSDARG0000008778018
vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSDARG0000004471818
tiam2b / T cell lymphoma invasion and metastasis 2b / TIAM2* / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSDARG0000009823314
si:ch73-383g2.1ENSDARG000000571077
si:dkey-21o19.2ENSDARG000000889005
CABZ01114581.1ENSDARG000001125260
vav3a / vav 3 guanine nucleotide exchange factor aENSDARG000000866230


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0046847 filopodium assembly IMP
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001286 caudal vein plexus caudal vein plexus decreased width , abnormal
caudal vein plexus malformed , abnormal
caudal vein plexus sprouting angiogenesis process quality , abnormal
caudal vein plexus angiogenic sprout decreased amount , abnormal
caudal vein plexus blood vessel endothelial cell has fewer parts of type blood vessel endothelial cell filopodium, abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000091459 gabra2a / gamma-aminobutyric acid type A receptor alpha2 subunit a / P47869* / GABRA2* / P26048* / Gamma-aminobutyric acid receptor subunit alpha-2 * / gamma-aminobutyric acid type A recept...  / complex






 

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