ENSDARG00000071692


Danio rerio

Features
Gene ID: ENSDARG00000071692
  
Biological name :prex2
  
Synonyms : phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 / prex2
  
Possible biological names infered from orthology : Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q3LAC4 / Q70Z35
  
Species: Danio rerio
  
Chr. number: 24
Strand: 1
Band:
Gene start: 18948665
Gene end: 19207056
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000096964
NCBI entrez gene - 557288     See in Manteia.
RefSeq - XM_001923322
swissprot - E7F2H9
ZFIN ID - ZDB-GENE-091113-37
Ensembl - ENSDARG00000071692
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PREX2ENSGALG00000042354Gallus gallus
 PREX2ENSG00000046889Homo sapiens
 Prex2ENSMUSG00000048960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prex1 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSDARG0000007579355
arhgef4 / Rho guanine nucleotide exchange factor (GEF) 4 / Q7TNR9* / Q9NR80* / Rho guanine nucleotide exchange factor 4*ENSDARG0000001291410
spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSDARG000000628379
arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG000000062998
arhgef9b / Cdc42 guanine nucleotide exchange factor (GEF) 9b / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG000000786248
vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSDARG000000447188
arhgef9a / Cdc42 guanine nucleotide exchange factor (GEF) 9a / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG000000617468
tiam1b / T cell lymphoma invasion and metastasis 1b / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG000000259208
vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*ENSDARG000000759628
arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSDARG000000066837
tiam1a / T cell lymphoma invasion and metastasis 1a / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG000000784307
arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG000000738487
tiam2a / T cell lymphoma invasion and metastasis 2a / TIAM2* / Q8IVF5* / Q6ZPF3* / T cell lymphoma invasion and metastasis 2* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSDARG000000877807
tiam2b / T cell lymphoma invasion and metastasis 2b / TIAM2* / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSDARG000000982336
vav3a / vav 3 guanine nucleotide exchange factor aENSDARG000000866232
si:dkey-21o19.2ENSDARG000000889002
si:ch73-383g2.1ENSDARG000000571072
CABZ01114581.1ENSDARG000001125260


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000591  DEP domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IBA


Pathways (from Reactome)
Pathway description
Regulation of PTEN stability and activity


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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