ENSDARG00000006683


Danio rerio

Features
Gene ID: ENSDARG00000006683
  
Biological name :arhgef6
  
Synonyms : arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
  
Possible biological names infered from orthology : Q15052 / Rac/Cdc42 guanine nucleotide exchange factor 6
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 31799787
Gene end: 31856819
  
Corresponding Affymetrix probe sets: Dr.2646.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000007758
Ensembl peptide - ENSDARP00000142213
Ensembl peptide - ENSDARP00000123688
NCBI entrez gene - 558288     See in Manteia.
RefSeq - XM_681489
swissprot - E7F836
swissprot - A0A140LG35
swissprot - F8W5F0
ZFIN ID - ZDB-GENE-101013-2
Ensembl - ENSDARG00000006683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q5ZLR6ENSGALG00000006439Gallus gallus
 Q15052ENSG00000129675Homo sapiens
 Arhgef6ENSMUSG00000031133Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef7b / Rho guanine nucleotide exchange factor (GEF) 7b / Q14155* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG0000007384859
arhgef7a / Rho guanine nucleotide exchange factor (GEF) 7a / Q14155* / Q9ES28* / ARHGEF7* / Rho guanine nucleotide exchange factor 7*ENSDARG0000000629958
arhgef4 / Rho guanine nucleotide exchange factor (GEF) 4 / Q7TNR9* / Q9NR80* / Rho guanine nucleotide exchange factor 4*ENSDARG0000001291415
tiam1b / T cell lymphoma invasion and metastasis 1b / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG0000002592015
tiam2a / T cell lymphoma invasion and metastasis 2a / TIAM2* / Q8IVF5* / Q6ZPF3* / T cell lymphoma invasion and metastasis 2* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSDARG0000008778015
spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSDARG0000006283715
tiam1a / T cell lymphoma invasion and metastasis 1a / TIAM1* / Q13009* / T cell lymphoma invasion and metastasis 1*ENSDARG0000007843015
arhgef9a / Cdc42 guanine nucleotide exchange factor (GEF) 9a / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG0000006174614
prex1 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSDARG0000007579314
prex2 / phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSDARG0000007169214
vav2 / vav 2 guanine nucleotide exchange factor / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSDARG0000004471813
vav3b / vav 3 guanine nucleotide exchange factor b / VAV3* / Q9UKW4* / Q9R0C8* / vav 3 oncogene* / vav guanine nucleotide exchange factor 3*ENSDARG0000007596213
arhgef9b / Cdc42 guanine nucleotide exchange factor (GEF) 9b / O43307* / Q3UTH8* / ARHGEF9* / Rho guanine nucleotide exchange factor 9 * / Cdc42 guanine nucleotide exchange factor 9*ENSDARG0000007862413
tiam2b / T cell lymphoma invasion and metastasis 2b / TIAM2* / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSDARG000000982337
si:ch73-383g2.1ENSDARG000000571076
si:dkey-21o19.2ENSDARG000000889005
CABZ01114581.1ENSDARG000001125263
vav3a / vav 3 guanine nucleotide exchange factor aENSDARG000000866231


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR032409  Rho guanine nucleotide exchange factor, coiled-coil domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019117 parvb / parvin, beta / Q9ES46* / Q9HBI1*  / complex / reaction






 

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