ENSGALG00000006439


Gallus gallus

Features
Gene ID: ENSGALG00000006439
  
Biological name :ARHGEF6
  
Synonyms : ARHGEF6 / Q5ZLR6 / Rho guanine nucleotide exchange factor 6
  
Possible biological names infered from orthology : Q15052 / Rac/Cdc42 guanine nucleotide exchange factor 6
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 4402043
Gene end: 4431398
  
Corresponding Affymetrix probe sets: GgaAffx.11771.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049895
Ensembl peptide - ENSGALP00000010376
NCBI entrez gene - 422247     See in Manteia.
RefSeq - XM_015278265
RefSeq - NM_001006432
RefSeq - XM_015278264
RefSeq Peptide - NP_001006432
swissprot - Q5ZLR6
swissprot - F1NEF5
swissprot - A0A1D5PAX8
Ensembl - ENSGALG00000006439
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef6ENSDARG00000006683Danio rerio
 Q15052ENSG00000129675Homo sapiens
 Arhgef6ENSMUSG00000031133Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARHGEF7 / Rho guanine nucleotide exchange factor 7 / Q14155* / Q9ES28*ENSGALG0000003100956
TIAM2 / T cell lymphoma invasion and metastasis 2 / Q6ZPF3* / Q8IVF5* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSGALG0000003600517
TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSGALG0000001584217
PREX1 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSGALG0000000462116
ARHGEF4 / Rho guanine nucleotide exchange factor 4 / Q7TNR9* / Q9NR80*ENSGALG0000000219315
PREX2 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSGALG0000004235415
VAV2 / guanine nucleotide exchange factor VAV2 / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSGALG0000000269914
VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*ENSGALG0000003932714
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG0000003467414
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG0000000760814
ENSGALG000000018947
ENSGALG000000362531


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001715  Calponin homology domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR032409  Rho guanine nucleotide exchange factor, coiled-coil domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014201 PARVB / parvin beta / Q9ES46* / Q9HBI1*  / complex / reaction






 

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