ENSGALG00000031009


Gallus gallus

Features
Gene ID: ENSGALG00000031009
  
Biological name :ARHGEF7
  
Synonyms : ARHGEF7 / Rho guanine nucleotide exchange factor 7
  
Possible biological names infered from orthology : Q14155 / Q9ES28
  
Species: Gallus gallus
  
Chr. number: 1
Strand: 1
Band:
Gene start: 139355134
Gene end: 139413259
  
Corresponding Affymetrix probe sets: GgaAffx.10787.1.S1_at (Chicken Array)   GgaAffx.10787.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000044045
NCBI entrez gene - 418761     See in Manteia.
RefSeq - XM_004938542
RefSeq - XM_004938544
RefSeq - XM_004938545
RefSeq - XM_004938547
RefSeq - XM_015277869
RefSeq - XM_003640531
swissprot - A0A1D5NUM7
Ensembl - ENSGALG00000031009
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef7aENSDARG00000006299Danio rerio
 arhgef7bENSDARG00000073848Danio rerio
 Q14155ENSG00000102606Homo sapiens
 Q9ES28ENSMUSG00000031511Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q5ZLR6 / ARHGEF6 / Rho guanine nucleotide exchange factor 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSGALG0000000643966
PREX1 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q69ZK0* / Q8TCU6* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein *ENSGALG0000000462121
ARHGEF4 / Rho guanine nucleotide exchange factor 4 / Q7TNR9* / Q9NR80*ENSGALG0000000219317
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG0000003467416
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG0000000760816
TIAM2 / T cell lymphoma invasion and metastasis 2 / Q6ZPF3* / Q8IVF5* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSGALG0000003600515
PREX2 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSGALG0000004235415
TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSGALG0000001584215
VAV2 / guanine nucleotide exchange factor VAV2 / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSGALG0000000269914
VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*ENSGALG0000003932713
ENSGALG000000018948
ENSGALG000000362531


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR032409  Rho guanine nucleotide exchange factor, coiled-coil domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0060124 positive regulation of growth hormone secretion IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1904424 regulation of GTP binding IEA
 cellular_componentGO:0000322 storage vacuole IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
EGFR downregulation
NRAGE signals death through JNK
Rho GTPase cycle
Ephrin signaling
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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