ENSGALG00000004621


Gallus gallus

Features
Gene ID: ENSGALG00000004621
  
Biological name :PREX1
  
Synonyms : phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / PREX1
  
Possible biological names infered from orthology : Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q69ZK0 / Q8TCU6
  
Species: Gallus gallus
  
Chr. number: 20
Strand: -1
Band:
Gene start: 6385508
Gene end: 6529830
  
Corresponding Affymetrix probe sets: Gga.19667.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000007346
NCBI entrez gene - 419210     See in Manteia.
RefSeq - XM_015296691
RefSeq - XM_015296692
swissprot - F1NK47
Ensembl - ENSGALG00000004621
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prex1ENSDARG00000075793Danio rerio
 PREX1ENSG00000124126Homo sapiens
 Prex1ENSMUSG00000039621Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PREX2 / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 / Q3LAC4* / Q70Z35* / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein *ENSGALG0000004235438
ARHGEF4 / Rho guanine nucleotide exchange factor 4 / Q7TNR9* / Q9NR80*ENSGALG0000000219310
VAV2 / guanine nucleotide exchange factor VAV2 / Q60992* / P52735* / vav 2 oncogene* / vav guanine nucleotide exchange factor 2*ENSGALG000000026999
ARHGEF9 / Cdc42 guanine nucleotide exchange factor 9 / O43307* / Q3UTH8* / Rho guanine nucleotide exchange factor 9 *ENSGALG000000076089
Q96N96* / SPATA13* / AL359736.1* / spermatogenesis associated 13*ENSGALG000000346748
Q5ZLR6 / ARHGEF6 / Rho guanine nucleotide exchange factor 6 / Q15052* / Rac/Cdc42 guanine nucleotide exchange factor 6*ENSGALG000000064398
TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSGALG000000158428
ARHGEF7 / Rho guanine nucleotide exchange factor 7 / Q14155* / Q9ES28*ENSGALG000000310098
VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*ENSGALG000000393278
TIAM2 / T cell lymphoma invasion and metastasis 2 / Q6ZPF3* / Q8IVF5* / T-lymphoma invasion and metastasis-inducing protein 2 *ENSGALG000000360057
ENSGALG000000362535
ENSGALG000000018942


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000591  DEP domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011991  ArsR-like helix-turn-helix domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IBA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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