ENSMUSG00000039621


Mus musculus

Features
Gene ID: ENSMUSG00000039621
  
Biological name :Prex1
  
Synonyms : Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Prex1 / Q69ZK0
  
Possible biological names infered from orthology : phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 / Q8TCU6
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 166566342
Gene end: 166713832
  
Corresponding Affymetrix probe sets: 10489784 (MoGene1.0st)   1434069_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104869
Ensembl peptide - ENSMUSP00000096679
Ensembl peptide - ENSMUSP00000037180
NCBI entrez gene - 277360     See in Manteia.
MGI - MGI:3040696
RefSeq - NM_177782
RefSeq Peptide - NP_808450
swissprot - Q69ZK0
swissprot - I7HPV9
Ensembl - ENSMUSG00000039621
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prex1ENSDARG00000075793Danio rerio
 PREX1ENSGALG00000004621Gallus gallus
 PREX1ENSG00000124126Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG0000004896056
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG0000003750910
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199010
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG0000003372110
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG000000256569
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG000000096219
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG000000341169
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG000000238008
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG000000024898
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG000000315118
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG000000311338


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000591  DEP domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001478  PDZ domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036034  PDZ superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IGI
 biological_processGO:0030217 T cell differentiation IGI
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030593 neutrophil chemotaxis IGI
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0032007 negative regulation of TOR signaling IBA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IGI
 biological_processGO:0045785 positive regulation of cell adhesion IGI
 biological_processGO:0050773 regulation of dendrite development IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IGI
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IGI
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0043198 dendritic shaft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005543 phospholipid binding ISO
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IBA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew,Prex2Gt(RRD186)Byg/Prex2Gt(RRD186)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt2m1Ingm/Syt2m1Ingm
Genetic Background: Not Specified

Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020351 decreased vocalization "decrease in the production of vocal sound" [ORCID: orcid.org/0000-0003-4606-0597, PMID:26621702]
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Allelic Composition: Prex1tm1Hcew/Prex1tm1Hcew
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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