ENSMUSG00000037509


Mus musculus

Features
Gene ID: ENSMUSG00000037509
  
Biological name :Arhgef4
  
Synonyms : Arhgef4 / Q7TNR9 / Rho guanine nucleotide exchange factor 4
  
Possible biological names infered from orthology : Q9NR80
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 34678188
Gene end: 34813309
  
Corresponding Affymetrix probe sets: 10345404 (MoGene1.0st)   10345406 (MoGene1.0st)   10345409 (MoGene1.0st)   10345411 (MoGene1.0st)   1435033_at (Mouse Genome 430 2.0 Array)   1437656_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035980
Ensembl peptide - ENSMUSP00000148067
Ensembl peptide - ENSMUSP00000124906
Ensembl peptide - ENSMUSP00000124467
Ensembl peptide - ENSMUSP00000124213
Ensembl peptide - ENSMUSP00000124207
NCBI entrez gene - 226970     See in Manteia.
MGI - MGI:2442507
RefSeq - NM_183019
RefSeq Peptide - NP_898840
swissprot - E0CX56
swissprot - A0A1B0GST8
swissprot - Q3TQN9
swissprot - E9PYK8
swissprot - Q7TNR9
swissprot - E0CYG8
swissprot - E0CY60
Ensembl - ENSMUSG00000037509
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef4ENSDARG00000012914Danio rerio
 ARHGEF4ENSGALG00000002193Gallus gallus
 Q9NR80ENSG00000136002Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199064
Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*ENSMUSG0000002565660
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG0000003962136
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG0000004896031
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG0000000248922
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG0000002380021
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG0000000962121
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG0000003411621
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG0000003151121
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG0000003113320
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG0000003372119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030032 lamellipodium assembly IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0046847 filopodium assembly IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki ApcMin

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4+
Genetic Background: B6J.Cg-Arhgef4tm1Taki ApcMin

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003544 abnormal vascular endothelial cell migration "anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95387]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0005316 abnormal response to tactile stimuli "anomalous reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbx1tm1Bld/Tbx1tm3Bld,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

 MP:0010639 altered tumor pathology "any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

 MP:0012434 decreased intestinal adenoma incidence "less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki ApcMin

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4+
Genetic Background: B6J.Cg-Arhgef4tm1Taki ApcMin

Allelic Composition: ApcMin/Apc+,Arhgef4tm1Taki/Arhgef4tm1Taki,Spata13tm1Taki/Spata13tm1Taki
Genetic Background: B6J.Cg-Arhgef4tm1Taki Spata13tm1Taki ApcMin

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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