ENSMUSG00000025656


Mus musculus

Features
Gene ID: ENSMUSG00000025656
  
Biological name :Arhgef9
  
Synonyms : Arhgef9 / Q3UTH8 / Rho guanine nucleotide exchange factor 9
  
Possible biological names infered from orthology : Cdc42 guanine nucleotide exchange factor 9 / O43307
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: C3
Gene start: 95048935
Gene end: 95196856
  
Corresponding Affymetrix probe sets: 10605797 (MoGene1.0st)   1435974_at (Mouse Genome 430 2.0 Array)   1436258_at (Mouse Genome 430 2.0 Array)   1436577_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138258
Ensembl peptide - ENSMUSP00000143779
Ensembl peptide - ENSMUSP00000143373
Ensembl peptide - ENSMUSP00000143184
Ensembl peptide - ENSMUSP00000143086
Ensembl peptide - ENSMUSP00000142911
Ensembl peptide - ENSMUSP00000142905
Ensembl peptide - ENSMUSP00000142769
Ensembl peptide - ENSMUSP00000142615
Ensembl peptide - ENSMUSP00000138668
Ensembl peptide - ENSMUSP00000138461
Ensembl peptide - ENSMUSP00000109505
Ensembl peptide - ENSMUSP00000109508
Ensembl peptide - ENSMUSP00000109510
Ensembl peptide - ENSMUSP00000109514
Ensembl peptide - ENSMUSP00000109515
Ensembl peptide - ENSMUSP00000109516
Ensembl peptide - ENSMUSP00000109517
Ensembl peptide - ENSMUSP00000138147
Ensembl peptide - ENSMUSP00000138243
NCBI entrez gene - 236915     See in Manteia.
MGI - MGI:2442233
RefSeq - XM_006527992
RefSeq - XM_017318477
RefSeq - XM_017318476
RefSeq - XM_017318475
RefSeq - XM_017318474
RefSeq - XM_017318473
RefSeq - XM_011247585
RefSeq - XM_011247583
RefSeq - XM_011247582
RefSeq - NM_001033329
RefSeq - NM_001290384
RefSeq - XM_017318478
RefSeq - NM_001290385
RefSeq Peptide - NP_001277313
RefSeq Peptide - NP_001028501
RefSeq Peptide - NP_001277314
swissprot - Q3UTH8
swissprot - S4R1A7
swissprot - S4R1J2
swissprot - S4R1K5
swissprot - B1AXI6
swissprot - A0A0G2JE35
swissprot - A0A0G2JEH1
swissprot - A0A0G2JEU0
swissprot - A0A0G2JEU6
swissprot - A0A0G2JFA1
swissprot - A0A0G2JFI4
swissprot - A0A0G2JG02
swissprot - B1AXI2
swissprot - B1AXI4
Ensembl - ENSMUSG00000025656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef9aENSDARG00000061746Danio rerio
 arhgef9bENSDARG00000078624Danio rerio
 ARHGEF9ENSGALG00000007608Gallus gallus
 O43307ENSG00000131089Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Spata13 / spermatogenesis associated 13 / Q96N96* / AL359736.1*ENSMUSG0000002199062
Q7TNR9 / Arhgef4 / Rho guanine nucleotide exchange factor 4 / Q9NR80*ENSMUSG0000003750956
Prex1 / Q69ZK0 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein / Q8TCU6* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1*ENSMUSG0000003962129
Prex2 / Q3LAC4 / Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein / Q70Z35* / phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2*ENSMUSG0000004896028
Tiam2 / Q6ZPF3 / T-lymphoma invasion and metastasis-inducing protein 2 / Q8IVF5* / T cell lymphoma invasion and metastasis 2*ENSMUSG0000002380022
Tiam1 / T cell lymphoma invasion and metastasis 1 / Q13009*ENSMUSG0000000248921
Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*ENSMUSG0000000962120
Arhgef6 / Rac/Cdc42 guanine nucleotide exchange factor 6 / Q15052*ENSMUSG0000003113319
Q9ES28 / Arhgef7 / Rho guanine nucleotide exchange factor 7 / Q14155*ENSMUSG0000003151119
Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*ENSMUSG0000003411619
Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*ENSMUSG0000003372117


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035728  Rho guanine nucleotide exchange factor 9, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005938 cell cortex TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

Allelic Composition: Arhgef9tm1Betz/Y,Tg(Camk2a-cre)2834Lusc/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Arhgef9tm1Betz/Y,Emx1tm1(cre)Yql/Emx1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gdnftm1Rosl/Gdnftm1Rosl
Genetic Background: involves: 129S2/SvPas * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000560 Gabra2 / P26048 / Gamma-aminobutyric acid receptor subunit alpha-2 / P47869* / gamma-aminobutyric acid type A receptor alpha2 subunit*  / complex






 

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