ENSMUSG00000000560


Mus musculus

Features
Gene ID: ENSMUSG00000000560
  
Biological name :Gabra2
  
Synonyms : Gabra2 / Gamma-aminobutyric acid receptor subunit alpha-2 / P26048
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor alpha2 subunit / P47869
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: C3.1
Gene start: 70957597
Gene end: 71095849
  
Corresponding Affymetrix probe sets: 10530406 (MoGene1.0st)   1420299_at (Mouse Genome 430 2.0 Array)   1421738_at (Mouse Genome 430 2.0 Array)   1443865_at (Mouse Genome 430 2.0 Array)   1449807_x_at (Mouse Genome 430 2.0 Array)   1455444_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142892
Ensembl peptide - ENSMUSP00000143645
Ensembl peptide - ENSMUSP00000000572
NCBI entrez gene - 14395     See in Manteia.
MGI - MGI:95614
RefSeq - NM_008066
RefSeq - XM_006503733
RefSeq Peptide - NP_032092
swissprot - A0A0H2UKB5
swissprot - P26048
swissprot - Q544G1
swissprot - A0A0G2JGP5
Ensembl - ENSMUSG00000000560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GABRA2ENSDARG00000113737Danio rerio
 gabra2aENSDARG00000091459Danio rerio
 GABRA2ENSGALG00000014206Gallus gallus
 GABRA2ENSG00000151834Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabra1 / P62812 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 (Gabra1), transcript variant 2, mRNA. / P14867* / gamma-aminobutyric acid type A receptor alpha1 subunit*ENSMUSG0000001080377
Gabra3 / P26049 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 (Gabra3), transcript variant 3, mRNA. / P34903* / gamma-aminobutyric acid type A receptor alpha3 subunit*ENSMUSG0000003134373
Gabra5 / Q8BHJ7 / Gamma-aminobutyric acid receptor subunit alpha-5 / P31644* / gamma-aminobutyric acid type A receptor alpha5 subunit*ENSMUSG0000005507871
Gabra4 / Q9D6F4 / Gamma-aminobutyric acid receptor subunit alpha-4 / P48169* / gamma-aminobutyric acid type A receptor alpha4 subunit*ENSMUSG0000002921157
Gabra6 / P16305 / Gamma-aminobutyric acid receptor subunit alpha-6 / Q16445* / gamma-aminobutyric acid type A receptor alpha6 subunit*ENSMUSG0000002042855
Gabrg2 / P22723 / Gamma-aminobutyric acid receptor subunit gamma-2 / P18507* / gamma-aminobutyric acid type A receptor gamma2 subunit*ENSMUSG0000002043643
Gabrg1 / Q9R0Y8 / Gamma-aminobutyric acid receptor subunit gamma-1 / Q8N1C3* / gamma-aminobutyric acid type A receptor gamma1 subunit*ENSMUSG0000000126042
Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*ENSMUSG0000005502641
Gabre / P78334* / gamma-aminobutyric acid type A receptor epsilon subunit*ENSMUSG0000003134033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001390  Gamma-aminobutyric-acid A receptor, alpha subunit
 IPR005432  Gamma-aminobutyric-acid A receptor, alpha 2 subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001505 regulation of neurotransmitter levels ISO
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0006836 neurotransmitter transport ISO
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030285 integral component of synaptic vesicle membrane ISO
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060077 inhibitory synapse IDA
 cellular_componentGO:0098794 postsynapse IDA
 cellular_componentGO:1902711 GABA-A receptor complex ISO
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0008503 benzodiazepine receptor activity ISO
 molecular_functionGO:0022851 GABA-gated chloride ion channel activity ISO


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001982 reduced chemically-elicited antinociception "less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gngt1tm1Ogk/Gngt1+
Genetic Background: involves: 129

Allelic Composition: Gabra2tm1Uru/Gabra2tm1Uru,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Gabra2tm1Uru/Gabra2tm2.1Uru,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gngt1tm1Ogk/Gngt1+
Genetic Background: involves: 129

 MP:0002806 abnormal conditioned emotional response "defects in an emotional response that has been acquired by conditioning " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gabra2tm2.1Uru/Gabra2tm2.1Uru,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zeb1tm1Yhi/Zeb1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabra2tm2.1Uru/Gabra2tm2.1Uru,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

Allelic Composition: Gabra2tm1Uru/Gabra2tm1Uru,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA/2

Allelic Composition: Gabra2tm1Uru/Gabra2tm2.1Uru,Tg(Scn10a-cre)1Rkun/0
Genetic Background: involves: C57BL/6 * DBA/2 * SJL

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0009455 enhanced cued conditioning behavior "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Baxtm1Ofxa/Baxtm1Ofxa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gabra2tm1Dias/Gabra2tm1Dias
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009779 enhanced behavioral response to anesthetic "increase or exceleration in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mecp2tm1.1Vnar/Mecp2tm1.1Vnar
Genetic Background: B6N.129-Mecp2tm1.1Vnar

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025656 Q3UTH8 / Arhgef9 / Rho guanine nucleotide exchange factor 9 / O43307* / Cdc42 guanine nucleotide exchange factor 9*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr