ENSMUSG00000020436


Mus musculus

Features
Gene ID: ENSMUSG00000020436
  
Biological name :Gabrg2
  
Synonyms : Gabrg2 / Gamma-aminobutyric acid receptor subunit gamma-2 / P22723
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor gamma2 subunit / P18507
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A5
Gene start: 41910203
Gene end: 42000857
  
Corresponding Affymetrix probe sets: 10385283 (MoGene1.0st)   1418177_at (Mouse Genome 430 2.0 Array)   1437147_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000063812
Ensembl peptide - ENSMUSP00000064739
Ensembl peptide - ENSMUSP00000104913
NCBI entrez gene - 14406     See in Manteia.
MGI - MGI:95623
RefSeq - XM_006532200
RefSeq - NM_008073
RefSeq - NM_177408
RefSeq - XM_006532199
RefSeq Peptide - NP_032099
RefSeq Peptide - NP_803127
swissprot - P22723
swissprot - Q8C7N0
Ensembl - ENSMUSG00000020436
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabrg2ENSDARG00000053665Danio rerio
 GABRG2ENSGALG00000038042Gallus gallus
 GABRG2ENSG00000113327Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabrg1 / Q9R0Y8 / Gamma-aminobutyric acid receptor subunit gamma-1 / Q8N1C3* / gamma-aminobutyric acid type A receptor gamma1 subunit*ENSMUSG0000000126071
Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*ENSMUSG0000005502665
Gabra4 / Q9D6F4 / Gamma-aminobutyric acid receptor subunit alpha-4 / P48169* / gamma-aminobutyric acid type A receptor alpha4 subunit*ENSMUSG0000002921143
Gabra6 / P16305 / Gamma-aminobutyric acid receptor subunit alpha-6 / Q16445* / gamma-aminobutyric acid type A receptor alpha6 subunit*ENSMUSG0000002042842
Gabra1 / P62812 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 (Gabra1), transcript variant 2, mRNA. / P14867* / gamma-aminobutyric acid type A receptor alpha1 subunit*ENSMUSG0000001080342
Gabra2 / P26048 / Gamma-aminobutyric acid receptor subunit alpha-2 / P47869* / gamma-aminobutyric acid type A receptor alpha2 subunit*ENSMUSG0000000056041
Gabra3 / P26049 / Mus musculus gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 (Gabra3), transcript variant 3, mRNA. / P34903* / gamma-aminobutyric acid type A receptor alpha3 subunit*ENSMUSG0000003134341
Gabra5 / Q8BHJ7 / Gamma-aminobutyric acid receptor subunit alpha-5 / P31644* / gamma-aminobutyric acid type A receptor alpha5 subunit*ENSMUSG0000005507840
Gabre / P78334* / gamma-aminobutyric acid type A receptor epsilon subunit*ENSMUSG0000003134038


Protein motifs (from Interpro)
Interpro ID Name
 IPR005437  Gamma-aminobutyric-acid A receptor, gamma subunit
 IPR005439  Gamma-aminobutyric-acid A receptor, gamma 2 subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission IDA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0071420 cellular response to histamine IDA
 biological_processGO:1902476 chloride transmembrane transport IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060077 inhibitory synapse ISO
 cellular_componentGO:1902711 GABA-A receptor complex IMP
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IMP
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cyp26b1tm1.1Ptk/Cyp26b1tm1.1Ptk
Genetic Background: involves: 129S2/SvPas

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Npc1l1tm1Yaio/Npc1l1tm1Yaio
Genetic Background: C57BL/6-Npc1l1tm1Yaio

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gabrg2tm1.1(Gabrg2)Wwis/Gabrg2tm1.1(Gabrg2)Wwis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Raf1tm1Zim/Raf1tm1Zim
Genetic Background: involves: 129/Sv * CD-1

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gabrg2tm1Spet/Gabrg2tm1Spet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Gabrg2tm1.1(Gabrg2)Wwis/Gabrg2tm1.1(Gabrg2)Wwis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gabrg2tm1.1(Gabrg2)Wwis/Gabrg2tm1.1(Gabrg2)Wwis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gabrg2tm1.1(Gabrg2)Wwis/Gabrg2tm1.1(Gabrg2)Wwis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gabrg2tm1.1(Gabrg2)Wwis/Gabrg2tm1.1(Gabrg2)Wwis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gabrg2tm2Lusc/Gabrg2tm2Lusc,Tg(Camk2a-cre)T50Stl/0
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ticam1Lps2/Ticam1Lps2,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Gabrg2tm2Spet/Gabrg2+,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Gabrg2tm1Spet/Gabrg2tm1Spet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Gabrg2tm2Spet/Gabrg2+,Tg(Camk2a-tTA)1Mmay/0,Tg(tetO-cre)LC1Bjd/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Gabrg2tm1Spet/Gabrg2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Egfl7tm1Wye/Egfl7tm1Wye
Genetic Background: B6.129-Egfl7tm1Wye

Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Tg(Pcp2-cre)2Mpin/?,Tg(Pcp2-EGFP/Gabrg2)1Wul/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Gabrg2tm1Spet/Gabrg2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Gabrg2tm1Spet/Gabrg2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * DBA/2J

Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Gabrg2tm1.1(Gabrg2)Wwis/Gabrg2tm1.1(Gabrg2)Wwis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Gabrg2tm1Spet/Gabrg2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Allelic Composition: Gabrg2tm1Spet/Gabrg2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * DBA/2J

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Hdctm1.1(icre)Wwis/Hdc+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrg2tm1Spet/Gabrg2tm1Spet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock8cpm/Dock8pri
Genetic Background: C57BL/6J-Dock8cpm/Dock8pri

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dock8cpm/Dock8pri
Genetic Background: C57BL/6J-Dock8cpm/Dock8pri

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Dock8cpm/Dock8pri
Genetic Background: C57BL/6J-Dock8cpm/Dock8pri

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu/Gt(ROSA)26Sortm1(RNAi:Bmpr2)Dliu
Genetic Background: involves: 129 * C57BL/6J

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmo4tm1.1Gng/Lmo4tm1.1Gng
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Tg(Pcp2-cre)2Mpin/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gabrg2tm1Wul/Gabrg2tm1Wul,Tg(Pcp2-cre)2Mpin/?,Tg(Pcp2-EGFP/Gabrg2)1Wul/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Gabrg2tm1.1(Gabrg2)Wwis/Gabrg2tm1.1(Gabrg2)Wwis
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gad2tm1Oba/Gad2tm1Oba
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gabrg2tm1Spet/Gabrg2tm1Spet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gabrg2tm1Spet/Gabrg2tm1Spet
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Dock8cpm/Dock8pri
Genetic Background: C57BL/6J-Dock8cpm/Dock8pri

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031344 Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*  / complex
 ENSMUSG00000029212 Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*  / complex
 ENSMUSG00000033676 Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*  / complex
 ENSMUSG00000007653 Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*  / complex






 

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