ENSMUSG00000033676


Mus musculus

Features
Gene ID: ENSMUSG00000033676
  
Biological name :Gabrb3
  
Synonyms : Gabrb3 / Gamma-aminobutyric acid receptor subunit beta-3 / P63080
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor beta3 subunit / P28472
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B5
Gene start: 57419692
Gene end: 57828802
  
Corresponding Affymetrix probe sets: 10553773 (MoGene1.0st)   1421189_at (Mouse Genome 430 2.0 Array)   1421190_at (Mouse Genome 430 2.0 Array)   1435021_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038051
Ensembl peptide - ENSMUSP00000082337
Ensembl peptide - ENSMUSP00000118835
Ensembl peptide - ENSMUSP00000143353
NCBI entrez gene - 14402     See in Manteia.
MGI - MGI:95621
RefSeq - NM_001038701
RefSeq - NM_008071
RefSeq Peptide - NP_001033790
RefSeq Peptide - NP_032097
swissprot - Q8C446
swissprot - F6WUM4
swissprot - P63080
swissprot - F6ZYH6
Ensembl - ENSMUSG00000033676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GABRB3ENSGALG00000029392Gallus gallus
 GABRB3ENSG00000166206Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*ENSMUSG0000000765377
Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*ENSMUSG0000002921275
Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*ENSMUSG0000003134440
Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*ENSMUSG0000002828037
Gabrp / Q8QZW7 / Gamma-aminobutyric acid receptor subunit pi / O00591* / gamma-aminobutyric acid type A receptor pi subunit*ENSMUSG0000002015937
Glra4 / Q61603 / Glycine receptor subunit alpha-4 / Q5JXX5* / glycine receptor alpha 4*ENSMUSG0000001859536
Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) / A8MPY1*ENSMUSG0000007499136
Glra3 / glycine receptor alpha 3 / O75311*ENSMUSG0000003825735
Glra2 / Q7TNC8 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / P23416* / glycine receptor alpha 2*ENSMUSG0000001858935
Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*ENSMUSG0000002326735
Gabrd / P22933 / Gamma-aminobutyric acid receptor subunit delta / O14764* / gamma-aminobutyric acid type A receptor delta subunit*ENSMUSG0000002905435
Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*ENSMUSG0000000026334
Glrb / P48168 / Glycine receptor subunit beta / P48167* / glycine receptor beta*ENSMUSG0000002802031


Protein motifs (from Interpro)
Interpro ID Name
 IPR002289  Gamma-aminobutyric-acid A receptor, beta subunit
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:0060080 inhibitory postsynaptic potential IMP
 biological_processGO:0060119 inner ear receptor cell development IMP
 biological_processGO:0060384 innervation IMP
 biological_processGO:0071420 cellular response to histamine IEA
 biological_processGO:0090102 cochlea development IMP
 biological_processGO:1901215 negative regulation of neuron death IMP
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0060077 inhibitory synapse ISO
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:1902711 GABA-A receptor complex IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity ISS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0022851 GABA-gated chloride ion channel activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Gabrb3tm2.2Geh/Gabrb3tm2.2Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm2.2Geh/Gabrb3tm2.2Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0001394 circling "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0001400 hyperresponsive "increased reaction to touch" [J:39801]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001409 increased stereotypic behavior "more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, MGI:CLS, J:57125]
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Allelic Composition: Orai1tm1.1Hjm/Orai1tm1.1Hjm,Tg(Cd4-cre)1Cwi/0
Genetic Background: B6.Cg-Orai1tm1.1Hjm Tg(Cd4-cre)1Cwi

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fcer1gtm1Rav/Fcer1gtm1Rav,Tyrobptm1.1Viv/Tyrobptm1.1Viv
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002068 abnormal parental behavior "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rorctm1Litt/Rorctm1Litt
Genetic Background: involves: 129P2/OlaHsd

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gabrb3tm1Uru/Gabrb3tm1Uru
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0002857 cochlear ganglion degeneration "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm1Uru/Gabrb3tm1Uru
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
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Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0002911 abnormal inhibitory postsynaptic potential "defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0003637 cochlear ganglion hypoplasia "reduced numbers of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003986 small cochlear ganglion "reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003987 small vestibular ganglion "reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm1Uru/Gabrb3tm1Uru
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004398 cochlear inner hair cell degeneration "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004490 type IV spiral ligament fibrocyte degeneration "degeneration or loss of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004632 abnormal cochlear OHC efferent innervation "any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004716 abnormal cochlear nerve morphology "any structural abnormality in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004740 sensorineural hearing loss "a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004746 abnormal cochlear IHC afferent innervation "any changes in the morphology or number of afferent terminals and/or their synapses in the cochlear IHC region" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gabrb3tm1Uru/Gabrb3tm1Uru
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006409 vestibular ganglion hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cell bodies, in the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabrb3tm2.2Geh/Gabrb3tm2.2Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

Allelic Composition: Gabrb3tm1Uru/Gabrb3tm1Uru
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009939 abnormal hippocampus neuron morphology 
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Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0009957 abnormal cerebellum vermis lobule morphology "any structural anomaly of the region of a cerebellar lobule that resides in the central section of the cerebellum between the two hemispheres; in humans, vermis lobule regions may be nearly continuous with the cerebellar hemisphere lobules dorsally but are separated by deeper longitudinal fissues in the ventral regions; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17506688]
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0009989 abnormal cerebellum vermis lobule II morphology 
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0009990 abnormal cerebellum vermis lobule III morphology 
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0009991 abnormal cerebellum vermis lobule IV morphology 
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0009993 abnormal cerebellum vermis lobule V morphology 
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0009994 abnormal cerebellum vermis lobule VI morphology 
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0009995 abnormal cerebellum vermis lobule VII morphology 
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Allelic Composition: Foxn1tm1Tbo/Foxn1tm1Tbo
Genetic Background: involves: 129S1/Sv

 MP:0011083 complete lethality at weaning "premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food" [MGI:csmith]
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Allelic Composition: Gabrb3tm2.2Geh/Gabrb3tm2.2Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gabrb3tm2.2Geh/Gabrb3tm2.2Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gabrb3tm2.2Geh/Gabrb3tm2.2Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011269 increased excitatory postsynaptic current amplitude "increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Gabrb3tm2.1Geh/Gabrb3tm2.1Geh,Tg(Camk2a-cre)T29-1Stl/?
Genetic Background: involves: 129 * BALB/c * C57BL/6 * SJL

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Gabrb3tm1Geh/Gabrb3tm1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020335 abnormal dentate gyrus neuron dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron in one of two interlocking gyri of the hippocampus formation" [ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0020395 abnormal response to social novelty "any anomaly in the interaction of an individual with a familiar versus a novel individual of the same species; in mouse the typical behavior is is for increased interaction with the novel individual" [PMID:23280234]
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Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031344 Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*  / complex
 ENSMUSG00000033676 Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*  / complex
 ENSMUSG00000007653 Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*  / complex
 ENSMUSG00000029212 Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*  / complex
 ENSMUSG00000020436 Gabrg2 / P22723 / Gamma-aminobutyric acid receptor subunit gamma-2 / P18507* / gamma-aminobutyric acid type A receptor gamma2 subunit*  / complex
 ENSMUSG00000055026 Gabrg3 / P27681 / Gamma-aminobutyric acid receptor subunit gamma-3 / Q99928* / gamma-aminobutyric acid type A receptor gamma3 subunit*  / complex






 

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