ENSMUSG00000029054


Mus musculus

Features
Gene ID: ENSMUSG00000029054
  
Biological name :Gabrd
  
Synonyms : Gabrd / Gamma-aminobutyric acid receptor subunit delta / P22933
  
Possible biological names infered from orthology : gamma-aminobutyric acid type A receptor delta subunit / O14764
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 155384980
Gene end: 155398112
  
Corresponding Affymetrix probe sets: 10519124 (MoGene1.0st)   1449980_a_at (Mouse Genome 430 2.0 Array)   1457763_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030925
NCBI entrez gene - 14403     See in Manteia.
MGI - MGI:95622
RefSeq - XM_006538546
RefSeq - NM_008072
RefSeq Peptide - NP_032098
swissprot - P22933
swissprot - Q14AH9
Ensembl - ENSMUSG00000029054
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabrdENSDARG00000059763Danio rerio
 GABRDENSGALG00000001282Gallus gallus
 GABRDENSG00000187730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*ENSMUSG0000002921238
Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*ENSMUSG0000000765338
Gabrp / Q8QZW7 / Gamma-aminobutyric acid receptor subunit pi / O00591* / gamma-aminobutyric acid type A receptor pi subunit*ENSMUSG0000002015938
Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*ENSMUSG0000003367637
Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*ENSMUSG0000003134435
Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*ENSMUSG0000002326734
Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) / A8MPY1*ENSMUSG0000007499133
Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*ENSMUSG0000000026333
Glra2 / Q7TNC8 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / P23416* / glycine receptor alpha 2*ENSMUSG0000001858933
Glra4 / Q61603 / Glycine receptor subunit alpha-4 / Q5JXX5* / glycine receptor alpha 4*ENSMUSG0000001859533
Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*ENSMUSG0000002828033
Glra3 / glycine receptor alpha 3 / O75311*ENSMUSG0000003825733
Glrb / P48168 / Glycine receptor subunit beta / P48167* / glycine receptor beta*ENSMUSG0000002802028


Protein motifs (from Interpro)
Interpro ID Name
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008098  Gamma-aminobutyric-acid A receptor delta subunit
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007268 chemical synaptic transmission IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity IBA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001385 pup cannibalization "the killing and eating of newborn mice by the mother; can be a normal response if the mother does not recognize the pups as her own" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001454 abnormal cued conditioning behavior "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stip1tm1.2Mamp/Stip1+
Genetic Background: involves: C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002573 behavioral despair "depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli" [J:80395]
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stip1tm1.2Mamp/Stip1+
Genetic Background: involves: C57BL/6

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Stip1tm1.2Mamp/Stip1+
Genetic Background: involves: C57BL/6

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Gabrdtm1.1Jmag/Gabrd+,Gad2tm2(cre)Zjh/Gad2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003360 depression-related behavior 
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Allelic Composition: Tbx1tm1Bld/Del(16Es2el-Ufd1l)217Bld
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009778 impaired behavioral response to anesthetic "decrease or delay in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Cxcr4tm1Tng/Cxcr4tm2Tng
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011269 increased excitatory postsynaptic current amplitude "increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Gabrdtm1.1Jmag/Gabrd+,Gad2tm2(cre)Zjh/Gad2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011987 abnormal GABAergic neuron physiology "any functional anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter" [PMID:8787741]
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Allelic Composition: Gabrdtm1.1Jmag/Gabrd+,Gad2tm2(cre)Zjh/Gad2+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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