Manteia - Molecule gene

ENSMUSG00000018589

Mus musculus

Features

Gene ID:	ENSMUSG00000018589

Biological name :	Glra2

Synonyms :	Glra2 / Mus musculus glycine receptor, alpha 2 subunit (Glra2), transcript variant 3, mRNA. / Q7TNC8

Possible biological names infered from orthology :	glycine receptor alpha 2 / P23416

Species:	Mus musculus

Chr. number:	X
Strand:	-1
Band:	F5
Gene start:	165129017
Gene end:	165327393

Corresponding Affymetrix probe sets:	10607792 (MoGene1.0st) 1434098_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000060827 NCBI entrez gene - 237213 See in Manteia. MGI - MGI:95748 RefSeq - XM_006528836 RefSeq - NM_001357100 RefSeq - NM_183427 RefSeq - XM_006528833 RefSeq - XM_006528834 RefSeq - XM_006528835 RefSeq Peptide - NP_001344028 RefSeq Peptide - NP_001344029 RefSeq Peptide - NP_906272 swissprot - Q7TNC8 swissprot - Q3UTL8 Ensembl - ENSMUSG00000018589

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
GLRA2	ENSGALG00000016571	Gallus gallus
GLRA2	ENSG00000101958	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Glra4 / Q61603 / Glycine receptor subunit alpha-4 / Q5JXX5* / glycine receptor alpha 4*	ENSMUSG00000018595	80
Glra3 / glycine receptor alpha 3 / O75311*	ENSMUSG00000038257	78
Glra1 / Q64018 / Glycine receptor subunit alpha-1 / P23415* / glycine receptor alpha 1*	ENSMUSG00000000263	75
Glrb / P48168 / Glycine receptor subunit beta / P48167* / glycine receptor beta*	ENSMUSG00000028020	48
Gabrb1 / P50571 / Gamma-aminobutyric acid receptor subunit beta-1 / P18505* / gamma-aminobutyric acid type A receptor beta1 subunit*	ENSMUSG00000029212	36
Gabrb3 / P63080 / Gamma-aminobutyric acid receptor subunit beta-3 / P28472* / gamma-aminobutyric acid type A receptor beta3 subunit*	ENSMUSG00000033676	36
Gabrb2 / P63137 / Gamma-aminobutyric acid receptor subunit beta-2 / P47870* / gamma-aminobutyric acid type A receptor beta2 subunit*	ENSMUSG00000007653	36
Gabrd / P22933 / Gamma-aminobutyric acid receptor subunit delta / O14764* / gamma-aminobutyric acid type A receptor delta subunit*	ENSMUSG00000029054	33
Gabrq / Q9JLF1 / Gamma-aminobutyric acid receptor subunit theta / Q9UN88* / gamma-aminobutyric acid type A receptor theta subunit*	ENSMUSG00000031344	33
Gabrr1 / P56475 / Gamma-aminobutyric acid receptor subunit rho-1 / P24046* / gamma-aminobutyric acid type A receptor rho1 subunit*	ENSMUSG00000028280	32
Gabrr3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) / A8MPY1*	ENSMUSG00000074991	31
Gabrr2 / P56476 / Gamma-aminobutyric acid receptor subunit rho-2 / P28476* / gamma-aminobutyric acid type A receptor rho2 subunit*	ENSMUSG00000023267	31
Gabrp / Q8QZW7 / Gamma-aminobutyric acid receptor subunit pi / O00591* / gamma-aminobutyric acid type A receptor pi subunit*	ENSMUSG00000020159	31

Protein motifs (from Interpro)

Interpro ID	Name
IPR006028	Gamma-aminobutyric acid A receptor/Glycine receptor alpha
IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
IPR006201	Neurotransmitter-gated ion-channel
IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain
IPR008127	Glycine receptor alpha
IPR008129	Glycine receptor alpha2
IPR018000	Neurotransmitter-gated ion-channel, conserved site
IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily
IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006821	chloride transport	IEA
biological_process	GO:0007218	neuropeptide signaling pathway	IEA
biological_process	GO:0034220	ion transmembrane transport	ISO
biological_process	GO:0043200	response to amino acid	IBA
biological_process	GO:0060012	synaptic transmission, glycinergic	IBA
biological_process	GO:0060079	excitatory postsynaptic potential	IEA
biological_process	GO:0071230	cellular response to amino acid stimulus	IEA
biological_process	GO:0071294	cellular response to zinc ion	IEA
biological_process	GO:0071361	cellular response to ethanol	IEA
biological_process	GO:1902476	chloride transmembrane transport	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0005887	integral component of plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0034707	chloride channel complex	IEA
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0045202	synapse	IEA
cellular_component	GO:0045211	postsynaptic membrane	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005230	extracellular ligand-gated ion channel activity	IEA
molecular_function	GO:0005254	chloride channel activity	IEA
molecular_function	GO:0016594	glycine binding	IBA
molecular_function	GO:0016934	extracellularly glycine-gated chloride channel activity	IBA
molecular_function	GO:0022824	transmitter-gated ion channel activity	IEA
molecular_function	GO:0022852	glycine-gated chloride ion channel activity	ISO
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Neurotransmitter receptors and postsynaptic signal transmission

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002945	abnormal inhibitory postsynaptic currents	"defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Krt6a/Krt6b^tm1Cou/Krt6a/Krt6b^tm1Cou Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2
MP:0003463	abnormal single cell response	"altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]	Show Allelic Composition: F9^tm1Emg/Y Genetic Background: involves: 129S/SvEv * C57BL/6J
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	"any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Il6ra^tm1.1Jcbr/Il6ra^tm1.1Jcbr,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Glra2^tm1.2Lngu/Glra2^tm1.2Lngu,Tg(mI56i-cre,EGFP)1Kc/0 Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1
MP:0006009	abnormal neuronal migration	"defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Il6ra^tm1.1Jcbr/Il6ra^tm1.1Jcbr,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Glra2^tm1.2Lngu/Glra2^tm1.2Lngu,Tg(mI56i-cre,EGFP)1Kc/0 Genetic Background: involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000028020	Glrb / P48168 / Glycine receptor subunit beta / P48167* / glycine receptor beta*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr