ENSG00000101958


Homo sapiens

Features
Gene ID: ENSG00000101958
  
Biological name :GLRA2
  
Synonyms : GLRA2 / glycine receptor alpha 2 / P23416
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.2
Gene start: 14529298
Gene end: 14731812
  
Corresponding Affymetrix probe sets: 207462_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391606
Ensembl peptide - ENSP00000218075
Ensembl peptide - ENSP00000347123
Ensembl peptide - ENSP00000387756
NCBI entrez gene - 2742     See in Manteia.
OMIM - 305990
RefSeq - XM_017029429
RefSeq - NM_001118885
RefSeq - NM_001118886
RefSeq - NM_001171942
RefSeq - NM_002063
RefSeq - XM_006724487
RefSeq - XM_011545495
RefSeq - XM_011545496
RefSeq - XM_017029427
RefSeq - XM_017029428
RefSeq Peptide - NP_001112357
RefSeq Peptide - NP_001112358
RefSeq Peptide - NP_001165413
RefSeq Peptide - NP_002054
swissprot - C9JBL4
swissprot - P23416
Ensembl - ENSG00000101958
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GLRA2ENSGALG00000016571Gallus gallus
 Glra2ENSMUSG00000018589Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GLRA3 / O75311 / glycine receptor alpha 3ENSG0000014545179
GLRA1 / P23415 / glycine receptor alpha 1ENSG0000014588875
GLRA4 / Q5JXX5 / glycine receptor alpha 4ENSG0000018882872
GLRB / P48167 / glycine receptor betaENSG0000010973848
GABRB3 / P28472 / gamma-aminobutyric acid type A receptor beta3 subunitENSG0000016620637
GABRB1 / P18505 / gamma-aminobutyric acid type A receptor beta1 subunitENSG0000016328836
GABRB2 / P47870 / gamma-aminobutyric acid type A receptor beta2 subunitENSG0000014586436
GABRD / O14764 / gamma-aminobutyric acid type A receptor delta subunitENSG0000018773034
GABRQ / Q9UN88 / gamma-aminobutyric acid type A receptor theta subunitENSG0000026808933
GABRR1 / P24046 / gamma-aminobutyric acid type A receptor rho1 subunitENSG0000014627632
GABRR2 / P28476 / gamma-aminobutyric acid type A receptor rho2 subunitENSG0000011188632
GABRP / O00591 / gamma-aminobutyric acid type A receptor pi subunitENSG0000009475531
A8MPY1 / GABRR3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)ENSG0000018318530


Protein motifs (from Interpro)
Interpro ID Name
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008127  Glycine receptor alpha
 IPR008129  Glycine receptor alpha2
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007218 neuropeptide signaling pathway IDA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0034220 ion transmembrane transport IDA
 biological_processGO:0060012 synaptic transmission, glycinergic IBA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:0071294 cellular response to zinc ion IDA
 biological_processGO:0071361 cellular response to ethanol IDA
 biological_processGO:1902476 chloride transmembrane transport IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0016594 glycine binding IDA
 molecular_functionGO:0016934 extracellularly glycine-gated chloride channel activity IDA
 molecular_functionGO:0022824 transmitter-gated ion channel activity IEA
 molecular_functionGO:0022852 glycine-gated chloride ion channel activity IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109738 GLRB / P48167 / glycine receptor beta  / complex






 

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