ENSG00000268089


Homo sapiens

Features
Gene ID: ENSG00000268089
  
Biological name :GABRQ
  
Synonyms : GABRQ / gamma-aminobutyric acid type A receptor theta subunit / Q9UN88
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q28
Gene start: 152638183
Gene end: 152657534
  
Corresponding Affymetrix probe sets: 220886_at (Human Genome U133 Plus 2.0 Array)   238123_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000469332
NCBI entrez gene - 55879     See in Manteia.
OMIM - 300349
RefSeq - NM_018558
RefSeq - XM_011531184
RefSeq Peptide - NP_061028
swissprot - Q9UN88
Ensembl - ENSG00000268089
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabrb4ENSDARG00000099096Danio rerio
 GABRQENSGALG00000033183Gallus gallus
 GabrqENSMUSG00000031344Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GABRB1 / P18505 / gamma-aminobutyric acid type A receptor beta1 subunitENSG0000016328832
GABRB2 / P47870 / gamma-aminobutyric acid type A receptor beta2 subunitENSG0000014586431
GABRB3 / P28472 / gamma-aminobutyric acid type A receptor beta3 subunitENSG0000016620631
GABRD / O14764 / gamma-aminobutyric acid type A receptor delta subunitENSG0000018773024
GABRP / O00591 / gamma-aminobutyric acid type A receptor pi subunitENSG0000009475524
GLRA3 / O75311 / glycine receptor alpha 3ENSG0000014545124
GLRA2 / P23416 / glycine receptor alpha 2ENSG0000010195824
GLRA1 / P23415 / glycine receptor alpha 1ENSG0000014588824
GABRR1 / P24046 / gamma-aminobutyric acid type A receptor rho1 subunitENSG0000014627623
GABRR2 / P28476 / gamma-aminobutyric acid type A receptor rho2 subunitENSG0000011188623
GLRA4 / Q5JXX5 / glycine receptor alpha 4ENSG0000018882822
GLRB / P48167 / glycine receptor betaENSG0000010973822
A8MPY1 / GABRR3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)ENSG0000018318522


Protein motifs (from Interpro)
Interpro ID Name
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008101  Gamma-aminobutyric-acid A receptor theta subunit
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0004890 GABA-A receptor activity IBA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0005326 neurotransmitter transporter activity TAS


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission
GABA A receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000182256 GABRG3 / Q99928 / gamma-aminobutyric acid type A receptor gamma3 subunit  / complex
 ENSG00000156642 NPTN / Q9Y639 / neuroplastin  / reaction / complex
 ENSG00000113327 GABRG2 / P18507 / gamma-aminobutyric acid type A receptor gamma2 subunit  / complex
 ENSG00000145864 GABRB2 / P47870 / gamma-aminobutyric acid type A receptor beta2 subunit  / complex
 ENSG00000166206 GABRB3 / P28472 / gamma-aminobutyric acid type A receptor beta3 subunit  / complex
 ENSG00000163288 GABRB1 / P18505 / gamma-aminobutyric acid type A receptor beta1 subunit  / complex






 

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