ENSG00000111886


Homo sapiens

Features
Gene ID: ENSG00000111886
  
Biological name :GABRR2
  
Synonyms : GABRR2 / gamma-aminobutyric acid type A receptor rho2 subunit / P28476
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q15
Gene start: 89257208
Gene end: 89315299
  
Corresponding Affymetrix probe sets: 208217_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386029
NCBI entrez gene - 2570     See in Manteia.
OMIM - 137162
RefSeq - XM_011535717
RefSeq - NM_002043
RefSeq - XM_011535715
RefSeq - XM_011535716
RefSeq - XM_011535713
RefSeq - XM_011535714
RefSeq Peptide - NP_002034
swissprot - P28476
Ensembl - ENSG00000111886
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gabrr2aENSDARG00000052982Danio rerio
 gabrr2bENSDARG00000014057Danio rerio
 GABRR2ENSGALG00000015776Gallus gallus
 Gabrr2ENSMUSG00000023267Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GABRR1 / P24046 / gamma-aminobutyric acid type A receptor rho1 subunitENSG0000014627672
A8MPY1 / GABRR3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)ENSG0000018318559
GABRB1 / P18505 / gamma-aminobutyric acid type A receptor beta1 subunitENSG0000016328837
GABRB3 / P28472 / gamma-aminobutyric acid type A receptor beta3 subunitENSG0000016620636
GABRB2 / P47870 / gamma-aminobutyric acid type A receptor beta2 subunitENSG0000014586435
GLRA3 / O75311 / glycine receptor alpha 3ENSG0000014545134
GABRP / O00591 / gamma-aminobutyric acid type A receptor pi subunitENSG0000009475533
GABRQ / Q9UN88 / gamma-aminobutyric acid type A receptor theta subunitENSG0000026808932
GLRA1 / P23415 / glycine receptor alpha 1ENSG0000014588832
GABRD / O14764 / gamma-aminobutyric acid type A receptor delta subunitENSG0000018773031
GLRA2 / P23416 / glycine receptor alpha 2ENSG0000010195831
GLRB / P48167 / glycine receptor betaENSG0000010973831
GLRA4 / Q5JXX5 / glycine receptor alpha 4ENSG0000018882829


Protein motifs (from Interpro)
Interpro ID Name
 IPR006028  Gamma-aminobutyric acid A receptor/Glycine receptor alpha
 IPR006029  Neurotransmitter-gated ion-channel transmembrane domain
 IPR006201  Neurotransmitter-gated ion-channel
 IPR006202  Neurotransmitter-gated ion-channel ligand-binding domain
 IPR008057  Gamma-aminobutyric-acid A receptor, Rho
 IPR008059  Gamma-aminobutyric-acid A receptor, Rho2
 IPR018000  Neurotransmitter-gated ion-channel, conserved site
 IPR036719  Neurotransmitter-gated ion-channel transmembrane domain superfamily
 IPR036734  Neurotransmitter-gated ion-channel ligand-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006821 chloride transport IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007214 gamma-aminobutyric acid signaling pathway IEA
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0034707 chloride channel complex IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:1902711 GABA-A receptor complex IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004890 GABA-A receptor activity TAS
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005230 extracellular ligand-gated ion channel activity IEA
 molecular_functionGO:0005254 chloride channel activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
GABA A (rho) receptor activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000111886 GABRR2 / P28476 / gamma-aminobutyric acid type A receptor rho2 subunit  / complex
 ENSG00000146276 GABRR1 / P24046 / gamma-aminobutyric acid type A receptor rho1 subunit  / complex
 ENSG00000183185 A8MPY1 / GABRR3 / gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr