ENSG00000156642


Homo sapiens

Features
Gene ID: ENSG00000156642
  
Biological name :NPTN
  
Synonyms : neuroplastin / NPTN / Q9Y639
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q24.1
Gene start: 73560014
Gene end: 73634134
  
Corresponding Affymetrix probe sets: 202228_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000457470
Ensembl peptide - ENSP00000456349
Ensembl peptide - ENSP00000457028
Ensembl peptide - ENSP00000290401
Ensembl peptide - ENSP00000342958
Ensembl peptide - ENSP00000455671
Ensembl peptide - ENSP00000456033
NCBI entrez gene - 27020     See in Manteia.
OMIM - 612820
RefSeq - XM_011521452
RefSeq - NM_001161363
RefSeq - NM_001161364
RefSeq - NM_012428
RefSeq - NM_017455
RefSeq Peptide - NP_001154835
RefSeq Peptide - NP_059429
RefSeq Peptide - NP_001154836
RefSeq Peptide - NP_036560
swissprot - Q9Y639
swissprot - H3BU51
swissprot - Q9UFM8
swissprot - H3BQ94
Ensembl - ENSG00000156642
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nptnaENSDARG00000103002Danio rerio
 nptnbENSDARG00000043864Danio rerio
 NPTNENSGALG00000001741Gallus gallus
 NptnENSMUSG00000032336Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BSG / P35613 / basigin (Ok blood group)ENSG0000017227039
EMB / Q6PCB8 / embiginENSG0000017057116


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR027112  Neuroplastin
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008542 visual learning IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway ISS
 biological_processGO:0048170 positive regulation of long-term neuronal synaptic plasticity ISS
 biological_processGO:0050804 modulation of chemical synaptic transmission IEA
 biological_processGO:0050808 synapse organization IEA
 biological_processGO:0060291 long-term synaptic potentiation ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1902683 regulation of receptor localization to synapse IEA
 biological_processGO:1903829 positive regulation of cellular protein localization IEA
 biological_processGO:1904861 excitatory synapse assembly IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface HDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042734 presynaptic membrane ISS
 cellular_componentGO:0060077 inhibitory synapse IEA
 cellular_componentGO:0097060 synaptic membrane IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005105 type 1 fibroblast growth factor receptor binding ISS
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding ISS


Pathways (from Reactome)
Pathway description
Neurotransmitter receptors and postsynaptic signal transmission


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000268089 GABRQ / Q9UN88 / gamma-aminobutyric acid type A receptor theta subunit  / complex / reaction
 ENSG00000182256 GABRG3 / Q99928 / gamma-aminobutyric acid type A receptor gamma3 subunit  / reaction / complex
 ENSG00000163288 GABRB1 / P18505 / gamma-aminobutyric acid type A receptor beta1 subunit  / reaction / complex
 ENSG00000145864 GABRB2 / P47870 / gamma-aminobutyric acid type A receptor beta2 subunit  / reaction / complex
 ENSG00000166206 GABRB3 / P28472 / gamma-aminobutyric acid type A receptor beta3 subunit  / complex / reaction
 ENSG00000113327 GABRG2 / P18507 / gamma-aminobutyric acid type A receptor gamma2 subunit  / reaction / complex






 

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