ENSMUSG00000032336


Mus musculus

Features
Gene ID: ENSMUSG00000032336
  
Biological name :Nptn
  
Synonyms : Neuroplastin / Nptn / P97300
  
Possible biological names infered from orthology : Q9Y639
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 58582240
Gene end: 58657955
  
Corresponding Affymetrix probe sets: 10585842 (MoGene1.0st)   1415821_at (Mouse Genome 430 2.0 Array)   1441457_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135886
Ensembl peptide - ENSMUSP00000109756
Ensembl peptide - ENSMUSP00000134761
Ensembl peptide - ENSMUSP00000135576
Ensembl peptide - ENSMUSP00000082793
Ensembl peptide - ENSMUSP00000135199
Ensembl peptide - ENSMUSP00000134977
Ensembl peptide - ENSMUSP00000135250
Ensembl peptide - ENSMUSP00000135316
Ensembl peptide - ENSMUSP00000135541
NCBI entrez gene - 20320     See in Manteia.
MGI - MGI:108077
RefSeq - XM_006510882
RefSeq - XM_006510884
RefSeq - XM_006510885
RefSeq - XM_006510886
RefSeq - XM_017313224
RefSeq - NM_001293673
RefSeq - NM_009145
RefSeq - XM_006510883
RefSeq Peptide - NP_001280602
RefSeq Peptide - NP_033171
swissprot - Z4YLB7
swissprot - A0A0A0MQN8
swissprot - H3BIX4
swissprot - H3BKA7
swissprot - H3BKY2
swissprot - P97300
Ensembl - ENSMUSG00000032336
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nptnaENSDARG00000103002Danio rerio
 nptnbENSDARG00000043864Danio rerio
 NPTNENSGALG00000001741Gallus gallus
 NPTNENSG00000156642Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*ENSMUSG0000002317535
Emb / P21995 / Embigin / Q6PCB8*ENSMUSG0000002172827


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR027112  Neuroplastin
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway ISS
 biological_processGO:0048170 positive regulation of long-term neuronal synaptic plasticity ISS
 biological_processGO:0050804 modulation of chemical synaptic transmission IMP
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0060291 long-term synaptic potentiation ISS
 biological_processGO:1902683 regulation of receptor localization to synapse IMP
 biological_processGO:1904861 excitatory synapse assembly IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0042734 presynaptic membrane ISS
 molecular_functionGO:0005105 type 1 fibroblast growth factor receptor binding ISS
 molecular_functionGO:0050839 cell adhesion molecule binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
Show

Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
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Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fmr1tm1Cgr/Y,Tg(ACTB-Eif4e)#Ppp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0004402 decreased cochlear outer hair cell number "decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

 MP:0004433 abnormal cochlear inner hair cell physiology "anomalies in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

 MP:0004562 abnormal inner hair cell synaptic ribbon morphology "any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmr1tm1Cgr/Y,Tg(ACTB-Eif4e)#Ppp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmr1tm1Cgr/Y,Tg(ACTB-Eif4e)#Ppp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005191 head tilt "condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0009435 abnormal miniature inhibitory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fmr1tm1Cgr/Y,Tg(ACTB-Eif4e)#Ppp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fmr1tm1Cgr/Y,Tg(ACTB-Eif4e)#Ppp/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0010123 increased bone mineral content "elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Npc1tm1b(EUCOMM)Hmgu/Npc1+
Genetic Background: C57BL/6N-Npc1tm1b(EUCOMM)Hmgu/H

Allelic Composition: NptnY219X/NptnY219X
Genetic Background: involves: BALB/c * C3H/HeH * C57BL/6J

Allelic Composition: Nptnpitch/NptnY219X
Genetic Background: involves: BALB/c * C3H * C3H/HeH * C57BL/6J

Allelic Composition: Nptnpitch/Nptnpitch
Genetic Background: involves: C3H * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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