ENSMUSG00000023175


Mus musculus

Features
Gene ID: ENSMUSG00000023175
  
Biological name :Bsg
  
Synonyms : Basigin / Bsg / P18572
  
Possible biological names infered from orthology : basigin (Ok blood group) / P35613
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79704491
Gene end: 79711969
  
Corresponding Affymetrix probe sets: 10364468 (MoGene1.0st)   1456616_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101020
Ensembl peptide - ENSMUSP00000136487
Ensembl peptide - ENSMUSP00000137126
Ensembl peptide - ENSMUSP00000070751
NCBI entrez gene - 12215     See in Manteia.
MGI - MGI:88208
RefSeq - NM_009768
RefSeq - NM_001077184
RefSeq Peptide - NP_001070652
RefSeq Peptide - NP_033898
swissprot - P18572
swissprot - J3QP71
swissprot - K3W4Q8
Ensembl - ENSMUSG00000023175
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bsgENSDARG00000019881Danio rerio
 BSGENSGALG00000001328Gallus gallus
 BSGENSG00000172270Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nptn / P97300 / Neuroplastin / Q9Y639*ENSMUSG0000003233625
Emb / P21995 / Embigin / Q6PCB8*ENSMUSG0000002172817


Protein motifs (from Interpro)
Interpro ID Name
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR009151  Basigin
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007566 embryo implantation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0046689 response to mercury ion IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 cellular_componentGO:0002080 acrosomal membrane IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005537 mannose binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Basigin interactions
Integrin cell surface interactions
Proton-coupled monocarboxylate transport
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gbatm2.1Eginn/Gbatm2.1Eginn
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

 MP:0011103 partial embryonic lethality at implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at the point of implantation (Mus: E4.5)" [MGI:csmith]
Show

Allelic Composition: Il11ra1tm2Gos/Il11ra1tm2Gos
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Bsgtm1Tmu/Bsgtm1Tmu
Genetic Background: involves: 129/Sv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007655 Cav1 / P49817 / Caveolin-1 / Q03135*  / reaction / complex
 ENSMUSG00000051457 Spn / P15702 / sialophorin / P16150*  / reaction / complex
 ENSMUSG00000041329 Atp1b2 / P14231 / Sodium/potassium-transporting ATPase subunit beta-2 / P14415* / ATPase Na+/K+ transporting subunit beta 2*  / complex / reaction
 ENSMUSG00000032988 O35308 / Slc16a8 / solute carrier family 16 (monocarboxylic acid transporters), member 8 / O95907* / solute carrier family 16 member 8*  / reaction / complex
 ENSMUSG00000032412 Atp1b3 / P97370 / Sodium/potassium-transporting ATPase subunit beta-3 / P54709* / ATPase Na+/K+ transporting subunit beta 3*  / complex / reaction
 ENSMUSG00000022771 Ppil2 / Q9D787 / Mus musculus peptidylprolyl isomerase (cyclophilin)-like 2 (Ppil2), transcript variant 4, mRNA. / Q13356* / peptidylprolyl isomerase like 2*  / reaction / complex
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / reaction / complex
 ENSMUSG00000025809 Itgb1 / P09055 / Integrin beta-1 / P05556* / integrin subunit beta 1*  / reaction / complex
 ENSMUSG00000001507 Itga3 / Q62470 / Integrin alpha-3 Integrin alpha-3 heavy chain Integrin alpha-3 light chain / P26006* / integrin subunit alpha 3*  / complex / reaction
 ENSMUSG00000032902 P53986 / Slc16a1 / solute carrier family 16 (monocarboxylic acid transporters), member 1 / P53985* / solute carrier family 16 member 1*  / reaction / complex
 ENSMUSG00000027111 Itga6 / Q61739 / Integrin alpha-6 Integrin alpha-6 heavy chain Integrin alpha-6 light chain / P23229* / integrin subunit alpha 6*  / complex / reaction
 ENSMUSG00000026576 Atp1b1 / P14094 / Sodium/potassium-transporting ATPase subunit beta-1 / P05026* / ATPase Na+/K+ transporting subunit beta 1*  / complex / reaction
 ENSMUSG00000036634 Mag / P20917 / Mus musculus myelin-associated glycoprotein (Mag), transcript variant 5, mRNA. / P20916* / myelin associated glycoprotein*  / reaction / complex
 ENSMUSG00000025161 P57787 / Slc16a3 / solute carrier family 16 (monocarboxylic acid transporters), member 3 / O15427* / solute carrier family 16 member 3*  / reaction / complex
 ENSMUSG00000055795 Gm5160 / PPIA* / P62937* / peptidylprolyl isomerase A*  / complex / reaction
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction / complex
 ENSMUSG00000071866 Ppia / P17742 / peptidylprolyl isomerase A / P62937*  / reaction / complex






 

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