ENSMUSG00000032902


Mus musculus

Features
Gene ID: ENSMUSG00000032902
  
Biological name :Slc16a1
  
Synonyms : P53986 / Slc16a1 / solute carrier family 16 (monocarboxylic acid transporters), member 1
  
Possible biological names infered from orthology : P53985 / solute carrier family 16 member 1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 104638668
Gene end: 104658462
  
Corresponding Affymetrix probe sets: 10495035 (MoGene1.0st)   1415802_at (Mouse Genome 430 2.0 Array)   1446274_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045216
NCBI entrez gene - 20501     See in Manteia.
MGI - MGI:106013
RefSeq - NM_009196
RefSeq Peptide - NP_033222
swissprot - P53986
swissprot - Q544N9
Ensembl - ENSMUSG00000032902
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc16a1aENSDARG00000016963Danio rerio
 slc16a1bENSDARG00000068572Danio rerio
 SLC16A1ENSGALG00000001717Gallus gallus
 P53985ENSG00000155380Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70451 / Slc16a7 / solute carrier family 16 (monocarboxylic acid transporters), member 7 / O60669* / solute carrier family 16 member 7*ENSMUSG0000002010256
P57787 / Slc16a3 / solute carrier family 16 (monocarboxylic acid transporters), member 3 / O15427* / solute carrier family 16 member 3*ENSMUSG0000002516141
O35308 / Slc16a8 / solute carrier family 16 (monocarboxylic acid transporters), member 8 / O95907* / solute carrier family 16 member 8*ENSMUSG0000003298838
G5E8K6 / Slc16a5 / solute carrier family 16 (monocarboxylic acid transporters), member 5 / O15375* / solute carrier family 16 member 5*ENSMUSG0000004577529
Q8BGC3 / Slc16a12 / solute carrier family 16 (monocarboxylic acid transporters), member 12 / solute carrier family 16 member 12*ENSMUSG0000000937827
B1AT66 / Slc16a6 / solute carrier family 16 (monocarboxylic acid transporters), member 6 / O15403* / solute carrier family 16 member 6*ENSMUSG0000004192027
Q8CE94 / Slc16a13 / solute carrier family 16 (monocarboxylic acid transporters), member 13 / Q7RTY0* / solute carrier family 16 member 13*ENSMUSG0000004436726
Q5NC32 / Slc16a11 / solute carrier family 16 (monocarboxylic acid transporters), member 11 / Q8NCK7* / solute carrier family 16 member 11*ENSMUSG0000004093825


Protein motifs (from Interpro)
Interpro ID Name
 IPR004743  Monocarboxylate transporter
 IPR011701  Major facilitator superfamily
 IPR020846  Major facilitator superfamily domain
 IPR030757  Monocarboxylate transporter 1
 IPR036259  MFS transporter superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0007098 centrosome cycle IEA
 biological_processGO:0015718 monocarboxylic acid transport IEA
 biological_processGO:0032094 response to food IMP
 biological_processGO:0035873 lactate transmembrane transport IEA
 biological_processGO:0035879 plasma membrane lactate transport IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0051780 behavioral response to nutrient IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IBA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0008028 monocarboxylic acid transmembrane transporter activity IBA
 molecular_functionGO:0015129 lactate transmembrane transporter activity ISO
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0097159 organic cyclic compound binding IEA


Pathways (from Reactome)
Pathway description
Basigin interactions
Proton-coupled monocarboxylate transport
Pyruvate metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0001666 abnormal nutrient absorption "anomalous ability of the body to take in constituents of food necessary for normal physiologic function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Flgft/Flgft,Tmem79ma/Tmem79ma
Genetic Background: involves: CBA/CaGr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / reaction / complex
 ENSMUSG00000032902 P53986 / Slc16a1 / solute carrier family 16 (monocarboxylic acid transporters), member 1 / P53985* / solute carrier family 16 member 1*  / complex / reaction
 ENSMUSG00000025161 P57787 / Slc16a3 / solute carrier family 16 (monocarboxylic acid transporters), member 3 / O15427* / solute carrier family 16 member 3*  / reaction
 ENSMUSG00000032988 O35308 / Slc16a8 / solute carrier family 16 (monocarboxylic acid transporters), member 8 / O95907* / solute carrier family 16 member 8*  / reaction






 

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