ENSMUSG00000007655


Mus musculus

Features
Gene ID: ENSMUSG00000007655
  
Biological name :Cav1
  
Synonyms : Cav1 / Caveolin-1 / P49817
  
Possible biological names infered from orthology : Q03135
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A2
Gene start: 17306335
Gene end: 17341452
  
Corresponding Affymetrix probe sets: 10536499 (MoGene1.0st)   1449145_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135374
Ensembl peptide - ENSMUSP00000120252
Ensembl peptide - ENSMUSP00000135875
Ensembl peptide - ENSMUSP00000007799
Ensembl peptide - ENSMUSP00000111113
Ensembl peptide - ENSMUSP00000111114
Ensembl peptide - ENSMUSP00000111115
Ensembl peptide - ENSMUSP00000111116
NCBI entrez gene - 12389     See in Manteia.
MGI - MGI:102709
RefSeq - XM_006504976
RefSeq - NM_001243064
RefSeq - NM_007616
RefSeq - XM_006504974
RefSeq - XM_006504975
RefSeq Peptide - NP_001229993
RefSeq Peptide - NP_031642
swissprot - H3BLQ4
swissprot - D3Z148
swissprot - P49817
swissprot - H3BKG0
swissprot - D3Z0J2
Ensembl - ENSMUSG00000007655
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cav1ENSDARG00000103747Danio rerio
 CAV1ENSGALG00000043287Gallus gallus
 CAV1ENSG00000105974Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cav3 / P51637 / Caveolin-3 / P56539*ENSMUSG0000006269454
Cav2 / Q9WVC3 / Caveolin-2 / P51636*ENSMUSG0000000005830


Protein motifs (from Interpro)
Interpro ID Name
 IPR001612  Caveolin
 IPR015504  Caveolin-1
 IPR018361  Caveolin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0000188 inactivation of MAPK activity IMP
 biological_processGO:0001525 angiogenesis IGI
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001666 response to hypoxia IMP
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IMP
 biological_processGO:0001960 negative regulation of cytokine-mediated signaling pathway IMP
 biological_processGO:0002026 regulation of the force of heart contraction IMP
 biological_processGO:0002931 response to ischemia IMP
 biological_processGO:0003057 regulation of the force of heart contraction by chemical signal IGI
 biological_processGO:0006641 triglyceride metabolic process IMP
 biological_processGO:0006816 calcium ion transport IMP
 biological_processGO:0006874 cellular calcium ion homeostasis IMP
 biological_processGO:0006897 endocytosis TAS
 biological_processGO:0006940 regulation of smooth muscle contraction IMP
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009617 response to bacterium ISO
 biological_processGO:0009968 negative regulation of signal transduction IDA
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IDA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0019065 receptor-mediated endocytosis of virus by host cell ISO
 biological_processGO:0019217 regulation of fatty acid metabolic process IMP
 biological_processGO:0019915 lipid storage IMP
 biological_processGO:0030193 regulation of blood coagulation ISO
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0030514 negative regulation of BMP signaling pathway ISO
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IMP
 biological_processGO:0030879 mammary gland development IMP
 biological_processGO:0031295 T cell costimulation ISS
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination ISO
 biological_processGO:0031623 receptor internalization ISS
 biological_processGO:0032091 negative regulation of protein binding ISO
 biological_processGO:0032092 positive regulation of protein binding ISO
 biological_processGO:0032570 response to progesterone ISO
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0033484 nitric oxide homeostasis IMP
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway ISO
 biological_processGO:0042310 vasoconstriction IMP
 biological_processGO:0042532 negative regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0043085 positive regulation of catalytic activity IMP
 biological_processGO:0043407 negative regulation of MAP kinase activity IMP
 biological_processGO:0043409 negative regulation of MAPK cascade IMP
 biological_processGO:0043627 response to estrogen ISO
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0045907 positive regulation of vasoconstriction IMP
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IMP
 biological_processGO:0048550 negative regulation of pinocytosis ISO
 biological_processGO:0051001 negative regulation of nitric-oxide synthase activity IMP
 biological_processGO:0051259 protein complex oligomerization IDA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration ISO
 biological_processGO:0051592 response to calcium ion IDA
 biological_processGO:0051899 membrane depolarization IMP
 biological_processGO:0052547 regulation of peptidase activity IMP
 biological_processGO:0055074 calcium ion homeostasis IMP
 biological_processGO:0060056 mammary gland involution IMP
 biological_processGO:0060355 positive regulation of cell adhesion molecule production ISO
 biological_processGO:0060546 negative regulation of necroptotic process IMP
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IMP
 biological_processGO:0070836 caveola assembly IGI
 biological_processGO:0071360 cellular response to exogenous dsRNA ISO
 biological_processGO:0071375 cellular response to peptide hormone stimulus IGI
 biological_processGO:0071455 cellular response to hyperoxia ISO
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IMP
 biological_processGO:0072584 caveolin-mediated endocytosis ISO
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IMP
 biological_processGO:0086098 angiotensin-activated signaling pathway involved in heart process IGI
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway ISO
 biological_processGO:0097190 apoptotic signaling pathway ISO
 biological_processGO:0098903 regulation of membrane repolarization during action potential ISO
 biological_processGO:0098911 regulation of ventricular cardiac muscle cell action potential IMP
 biological_processGO:1900027 regulation of ruffle assembly ISO
 biological_processGO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation IMP
 biological_processGO:1901380 negative regulation of potassium ion transmembrane transport ISO
 biological_processGO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction IMP
 biological_processGO:1903598 positive regulation of gap junction assembly IMP
 biological_processGO:1903609 negative regulation of inward rectifier potassium channel activity ISO
 biological_processGO:2000286 receptor internalization involved in canonical Wnt signaling pathway ISO
 biological_processGO:2000535 regulation of entry of bacterium into host cell ISO
 biological_processGO:2000811 negative regulation of anoikis IMP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway ISO
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0000139 Golgi membrane ISS
 cellular_componentGO:0002080 acrosomal membrane IDA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005901 caveola TAS
 cellular_componentGO:0005925 focal adhesion IDA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0034098 VCP-NPL4-UFD1 AAA ATPase complex ISO
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005198 structural molecule activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016504 peptidase activator activity IMP
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0044325 ion channel binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0048365 Rac GTPase binding ISO
 molecular_functionGO:0050998 nitric-oxide synthase binding ISO
 molecular_functionGO:0051117 ATPase binding ISO
 molecular_functionGO:0070320 inward rectifier potassium channel inhibitor activity ISO


Pathways (from Reactome)
Pathway description
eNOS activation
NOSTRIN mediated eNOS trafficking
Basigin interactions
Disassembly of the destruction complex and recruitment of AXIN to the membrane
VEGFR2 mediated vascular permeability


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gata3tm2Jeng/Gata3tm2Jeng
Genetic Background: Not Specified

 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ddit3tm2.1Dron/Ddit3tm2.1Dron,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Nr4a2tm1Omc/Nr4a2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0000630 mammary gland hyperplasia "increased size of mammary gland due to increased cell number" [J:63229]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: STOCK Cav1tm1Mls/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

 MP:0001553 abnormal circulating free fatty acids level "anomalous blood concentrations of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0001613 abnormal vasodilation "anomalous widening of the lumen of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hey2tm1Mtc/Hey2tm1Mtc
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kcnj6wv/Kcnj6+
Genetic Background: B6CBA Aw-J/A-Kcnj6wv

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Ddit3tm2.1Dron/Ddit3tm2.1Dron,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001885 mammary ductal hyperplasia 
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002016 ovarian cysts "cystic ovary; usually refers to a benign growth" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Enpp1asj/Enpp1asj
Genetic Background: C57BL/6J-Enpp1asj/GrsrJ

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,crsp/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,crsp/+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hif1atm3Rsjo/Hif1atm3Rsjo,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002182 abnormal astrocyte morphology "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0002314 abnormal respiratory mechanics "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * FVB/N

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: STOCK Cav1tm1Mls/J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: STOCK Cav1tm1Mls/J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls/J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003180 abnormal pulmonary endothelial cell surface 
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003191 abnormal cellular cholesterol metabolism "impaired regulation of cellular cholesterol levels" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls/J

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0003416 premature bone ossification "early onset of the formation of bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003426 pulmonary interstitial fibrosis "formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:63134]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Pesch/Cav1tm1Pesch,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: FVB.Cg-Cav1tm1Pesch Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0003492 abnormal involuntary movement "anomalies in movements that occur independent of planning (eg. reflexive behavior)" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls/J

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0003975 increased circulating VLDL triglyceride level "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0004129 abnormal respiratory quotient "anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0004149 increased bone strength "increased ability of bone to endure the application of force without yielding or breaking" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004150 absent caveolae "absence of the small pockets, vesicles, caves, or recesses communicating with the outside of a cell and extending inward, indenting the cytoplasm and the cell membrane" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls/J

 MP:0004250 tau protein deposits "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004697 abnormal thyroid follicular cell "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Acantm1(cre/ERT2)Crm/Acantm1(cre/ERT2)Crm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: STOCK Cav1tm1Mls/J

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ddit3tm2.1Dron/Ddit3tm2.1Dron,Sil1Gt(RST462)Byg/Sil1Gt(RST462)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * SJL

 MP:0005360 urolithiasis "presence of calculi in any part of the urinary system" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85461, J:85462]
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Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
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Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cav1tm1Pesch/Cav1tm1Pesch,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: FVB.Cg-Cav1tm1Pesch Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: STOCK Cav1tm1Mls/J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006080 CNS ischemia "abnormal incidence of or response to loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0006429 abnormal hyaline cartilage morphology "any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008033 impaired lipolysis "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0008034 enhanced lipolysis "increase in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008263 abnormal hippocampus CA1 region morphology 
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Allelic Composition: Pinx1tm1.1Kplu/Pinx1+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008904 abnormal mammary fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009082 uterus cysts "presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Enpp1asj/Enpp1asj
Genetic Background: C57BL/6J-Enpp1asj/GrsrJ

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,crsp/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,crsp/+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0009122 decreased white fat cell lipid droplet size "reduction in the size of the single large lipid droplet or vacuole of white fat cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0009251 enlarged endometrial glands "increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Enpp1asj/Enpp1asj
Genetic Background: C57BL/6J-Enpp1asj/GrsrJ

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,crsp/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,crsp/+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009671 abnormal uterus physiology "any anomaly in normal cyclical changes not due to anatomical defect" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Enpp1asj/Enpp1asj
Genetic Background: C57BL/6J-Enpp1asj/GrsrJ

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0010111 abnormal renal calcium reabsorption "any anomaly in the process by which calcium ions are transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

Allelic Composition: Cav1tm1Mls/Cav1+,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129/Sv * C57BL/6J * FVB/N * SJL

 MP:0010358 abnormal free fatty acids level "any anomaly in the concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0010398 decreased liver glycogen level "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cav3tm1Mls/Cav3tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Krc/Cav1tm1Krc
Genetic Background: involves: 129S4/SvJae * Black Swiss

 MP:0010855 pulmonary hyperemia "increased amount of blood flow into the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010896 decreased lung compliance "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls/J

 MP:0010901 abnormal pulmonary alveolar parenchyma morphology "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010935 increased airway resistance "greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls/J

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0010967 increased compact bone area "increase in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0011044 increased lung elastance "faster ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls/J

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: B6.Cg-Cav1tm1Mls

 MP:0011139 increased lung endothelial cell proliferation "greater ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls,Cdkn2atm1Rdp/Cdkn2atm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: FVB.Cg-Cav1tm1Mls

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Tgfbr2tm1Karl/Tgfbr2tm1Karl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cav1tm1Kur/Cav1tm1Kur
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0013401 increased endometrial gland number "greater than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna]
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Allelic Composition: Enpp1asj/Enpp1asj
Genetic Background: C57BL/6J-Enpp1asj/GrsrJ

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,crsp/crsp
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,crsp/+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

Allelic Composition: Cav1tm1.1Aia/Cav1tm1.1Aia,Rxfp2tm1Aia/Rxfp2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB

 MP:0020378 abnormal cell cytoskeleton morphology "any anomaly in the structure of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm" [GO:0005856, MGI:mberry]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: Not Specified

 MP:0020415 abnormal fibroblast chemotaxis "any anomaly in the directed movement of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0020416 decreased fibroblast chemotaxis "reduction in the directed movement response of a fibroblast cell population guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)" [mgi:anna, PMID:20231695]
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Allelic Composition: Cav1tm1Mls/Cav1tm1Mls
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / reaction / complex
 ENSMUSG00000034738 Q6WKZ7 / Nostrin / Q8IVI9* / nitric oxide synthase trafficking*  / complex / reaction
 ENSMUSG00000033335 Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*  / reaction / complex
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / reaction / complex
 ENSMUSG00000023175 Bsg / P18572 / Basigin / P35613* / basigin (Ok blood group)*  / complex / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000028978 Nos3 / P70313 / Nitric oxide synthase, endothelial / P29474* / nitric oxide synthase 3*  / complex / reaction






 

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